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Paper · 4362000

Augmentation of cytotoxic drug action by antibodies directed at cell surface.

Rubens RD and 1 other. Nature, 1974. Cited by 59 papers, by iCite.

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ConductScience Library. Augmentation of cytotoxic drug action by antibodies directed at cell surface. Papers, record 4362000. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4362000

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Augmentation of cytotoxic drug action by antibodies directed at cell surface.
PubMed
Journal
Nature
PubMed
Year
1974
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
59
iCite
Relative citation ratio, by iCite
2.05
iCite
Revised in PubMed
2026-10-10
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Rubens RDR D
2Dulbecco RR

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibodies, NeoplasmMajor topic
Cell DivisionMajor topic
ChlorambucilMajor topic
Animals
Cell Line
Cell Transformation, Neoplastic
Chromium Radioisotopes
Clone Cells
Cytotoxicity Tests, Immunologic
Immune Sera
Kidney
Mice
Polyomavirus

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References7

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,374,229Immunological aspects of trophoblastic neoplasia.Br J Cancer Suppl1973https://conductscience.org/library/papers/4374229PubMed
25,404,005Adsorption to human red blood cells of chlorambucil and other biological alkylating agents.Biochem Pharmacol1969https://conductscience.org/library/papers/5404005PubMed
34,553,765Antibody as carrier of chlorambucil.Cancer1972https://conductscience.org/library/papers/4553765PubMed
414,278,870SOME OBSERVATIONS ON THE REACTIONS OF CHLORAMBUCIL, AZO-MUSTARD (CB 1414), AND CYCLOPHOSPHAMIDE.Proc Can Cancer Conf1963https://conductscience.org/library/papers/14278870PubMed
54,986,716Selective destruction of target cells by diphtheria toxin conjugated to antibody directed against antigens on the cells.Science1970https://conductscience.org/library/papers/4986716PubMed
74,560,726Immunochemotherapy of cancer with chlorambucil-carrying antibody.Br Med J1972https://conductscience.org/library/papers/4560726PubMed
86,015,636Immunoradioactive agent against cancer.Br Med J1967https://conductscience.org/library/papers/6015636PubMed

Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 59 citations.

PMIDTitleJournalYearIn PapersSource
27,518,975Histochemical effects of the proteolytic enzyme brinase on ascites tumour cells.Ir J Med Sci1975https://conductscience.org/library/papers/27518975PubMed
6,988,099Oncostatic-antibody complexes in chemotherapy.Cancer Chemother Pharmacol1980https://conductscience.org/library/papers/6988099PubMed
6,809,124Immune guided missiles.Br Med J (Clin Res Ed)1982https://conductscience.org/library/papers/6809124PubMed
3,527,466Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview.Cancer Chemother Pharmacol1986https://conductscience.org/library/papers/3527466PubMed
2,418,949In vitro synergism between hybrid immunotoxins and chemotherapeutic drugs: relevance to immunotherapy of prostate carcinoma.Cancer Immunol Immunother1986https://conductscience.org/library/papers/2418949PubMed
1,233,080Augmentation of cytotoxic drug action and X-irradiation by antibodies.Br J Cancer1975https://conductscience.org/library/papers/1233080PubMed
1,174,447Aggregation of chlorambucil in vitro may cause misinterpretation of protein binding data.Br J Cancer1975https://conductscience.org/library/papers/1174447PubMed
856,027Measurement of polyene antibiotic-mediated erythrocyte damage by release of hemoglobin and radioactive chromium.Antimicrob Agents Chemother1977https://conductscience.org/library/papers/856027PubMed
834,290Targeting of drugs.Nature1977https://conductscience.org/library/papers/834290PubMed
625,344Toxicity of diphtheria toxin for lymphoblastoid cells is increased by conjugation to antilymphocytic globulin.Nature1978https://conductscience.org/library/papers/625344PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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