Paper · 4473725

Sequence analysis of immunoglobulin light chain messenger RNA.

Milstein C and 4 others. Nature, 1974. Cited by 113 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Sequence analysis of immunoglobulin light chain messenger RNA. Papers, record 4473725. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4473725

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Sequence analysis of immunoglobulin light chain messenger RNA.; PubMed
Journal: Nature; PubMed
Year: 1974; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4473725/; PubMed
DOI: https://doi.org/10.1038/252354a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 113; iCite
Relative citation ratio, by iCite: 2.39; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Milstein C	C
2	Brownlee GG	G G
3	Cartwright EM	E M
4	Jarvis JM	J M
5	Proudfoot NJ	N J

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Immunoglobulin Fragments	Major topic
RNA, Messenger	Major topic
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Centrifugation, Density Gradient
DNA
Electrophoresis, Polyacrylamide Gel
Genetic Code
Hydrolysis
Immunoglobulins
Mice
Myeloma Proteins
Oligonucleotides
Phosphorus Radioisotopes
Plasmacytoma
Protein Biosynthesis
Ribonucleases
Transcription, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by34

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 113 citations.

PMID	Title	Journal	Year	In Papers	Source
38,390,810	"How to Release or Not Release, That Is the Question." A Review of Interleukin-1 Cellular Release Mechanisms in Vascular Inflammation.	J Am Heart Assoc	2024	https://conductscience.org/library/papers/38390810	PubMed
24,408,583	Generation or multiple genetic specificities: origin of genetic polymorphism through gene regulation.	Theor Appl Genet	1977	https://conductscience.org/library/papers/24408583	PubMed
6,785,724	DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain.	Nucleic Acids Res	1981	https://conductscience.org/library/papers/6785724	PubMed
6,782,109	Membrane-bound ribosomes of myeloma cells. IV. mRNA complexity of free and membrane-bound polysomes.	J Cell Biol	1981	https://conductscience.org/library/papers/6782109	PubMed
6,458,017	Transcription of sea urchin histone genes in Escherichia coli.	Nucleic Acids Res	1981	https://conductscience.org/library/papers/6458017	PubMed
6,400,038	Human monoclonal antibodies: methods of production and some aspects of their application in oncology.	Med Oncol Tumor Pharmacother	1984	https://conductscience.org/library/papers/6400038	PubMed
6,170,937	Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing.	Nucleic Acids Res	1981	https://conductscience.org/library/papers/6170937	PubMed
3,924,598	From the structure of antibodies to the diversification of the immune response.	EMBO J	1985	https://conductscience.org/library/papers/3924598	PubMed
1,172,191	Continuous cultures of fused cells secreting antibody of predefined specificity.	Nature	1975	https://conductscience.org/library/papers/1172191	PubMed
1,128,665	Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.	Nature	1975	https://conductscience.org/library/papers/1128665	PubMed

1 to 10 of 34

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data3

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession	Source
GENBANK	J00552	GENBANK
GENBANK	J00560	GENBANK
GENBANK	J00600	GENBANK

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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