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Paper4530984

The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.

Segal DM and 5 others. Proc Natl Acad Sci U S A, 1974. Cited by 497 papers, by iCite.

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ConductScience Library. The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site. Papers, record 4530984. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4530984

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1974
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
497
iCite
Relative citation ratio, by iCite
10.4
iCite
Revised in PubMed
2019-05-01
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Segal DMD M
2Padlan EAE A
3Cohen GHG H
4Rudikoff SS
5Potter MM
6Davies DRD R

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Binding Sites, AntibodyMajor topic
CholineMajor topic
Immunoglobulin Fab FragmentsMajor topic
Amino Acid Sequence
Animals
Haptens
Mice
Models, Structural
Myeloma Proteins
Organophosphorus Compounds
Protein Conformation
X-Ray Diffraction

Source PubMed

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,162,931Mechanism of antibody synthesis: size differences between mouse kappa chains.Science1967https://conductscience.org/library/papers/4162931PubMed
25,685,102Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.Biopolymers1968https://conductscience.org/library/papers/5685102PubMed
35,257,969The covalent structure of an entire gammaG immunoglobulin molecule.Proc Natl Acad Sci U S A1969https://conductscience.org/library/papers/5257969PubMed
45,508,247An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.J Exp Med1970https://conductscience.org/library/papers/5508247PubMed
55,760,491The matching of physical models to three-dimensional electron-density maps: a simple optical device.J Mol Biol1968https://conductscience.org/library/papers/5760491PubMed
64,109,640Antigen-binding myeloma proteins in mice.Ann N Y Acad Sci1971https://conductscience.org/library/papers/4109640PubMed
74,112,641Contact regions for dinitrophenyl and menadione haptens in an immunoglobulin binding more than one antigen.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4112641PubMed
84,555,516Immunoglobulin-producing tumors and myeloma proteins of mice.Physiol Rev1972https://conductscience.org/library/papers/4555516PubMed
94,638,343The complete amino acid sequence of a mouse kappa light chain.Biochem J1972https://conductscience.org/library/papers/4638343PubMed
104,566,456Crystals of phosphorylcholine-binding Fab-fragments from mouse myeloma proteins: preparation and x-ray analysis.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4566456PubMed
114,517,781Structure at 4.5 A resolution of a phosphorylcholine-binding fab.Nat New Biol1973https://conductscience.org/library/papers/4517781PubMed
124,519,624Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4519624PubMed
134,129,807Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine.Science1974https://conductscience.org/library/papers/4129807PubMed
144,773,847Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.Biochemistry1973https://conductscience.org/library/papers/4773847PubMed
154,131,516Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine.J Exp Med1974https://conductscience.org/library/papers/4131516PubMed
164,856,206Changes of the conformation of rabbit IgG antibody caused by the specific binding of a hapten. X-ray small-angle studies.Eur J Biochem1974https://conductscience.org/library/papers/4856206PubMed
174,522,793Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4522793PubMed
184,524,622Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4524622PubMed
194,524,646The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4524646PubMed
204,851,220Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.Eur J Biochem1974https://conductscience.org/library/papers/4851220PubMed

See all 21 references

Cited by102

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 497 citations.

PMIDTitleJournalYearIn PapersSource
40,169,149Antibody numbering schemes: advances, comparisons and tools for antibody engineering.Protein Eng Des Sel2025https://conductscience.org/library/papers/40169149PubMed
35,832,747The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics.Leuk Res Rep2022https://conductscience.org/library/papers/35832747PubMed
33,957,11950 Years of structural immunology.J Biol Chem2021https://conductscience.org/library/papers/33957119PubMed
32,226,232Symposium 3: Non-enzymatic biocatalysts in nature and biotechnology.Fresenius J Anal Chem1990https://conductscience.org/library/papers/32226232PubMed
30,405,605Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used.Front Immunol2018https://conductscience.org/library/papers/30405605PubMed
26,870,003Ig Constant Region Effects on Variable Region Structure and Function.Front Microbiol2016https://conductscience.org/library/papers/26870003PubMed
26,864,111Engineered hapten-binding antibody derivatives for modulation of pharmacokinetic properties of small molecules and targeted payload delivery.Immunol Rev2016https://conductscience.org/library/papers/26864111PubMed
23,396,847Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.Proc Natl Acad Sci U S A2013https://conductscience.org/library/papers/23396847PubMed
18,962,897Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments.Mol Immunol2009https://conductscience.org/library/papers/18962897PubMed
11,412,305Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.Immunology2001https://conductscience.org/library/papers/11412305PubMed
10,862,788Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity.J Clin Invest2000https://conductscience.org/library/papers/10862788PubMed
10,859,335The structural basis of repertoire shift in an immune response to phosphocholine.J Exp Med2000https://conductscience.org/library/papers/10859335PubMed
9,879,504Do active site conformations of small ligands correspond to low free-energy solution structures?J Comput Aided Mol Des1998https://conductscience.org/library/papers/9879504PubMed
9,228,941Picture story. Nice guys needn't finish last.Nat Struct Biol1997https://conductscience.org/library/papers/9228941PubMed
8,995,065Antibody-antigen recognition: a canonical structure paradigm.J Mol Evol1996https://conductscience.org/library/papers/8995065PubMed
8,889,174Symmetry of Fv architecture is conducive to grafting a second antibody binding site in the Fv region.Biophys J1996https://conductscience.org/library/papers/8889174PubMed
8,877,702Comparative docking studies on ligand binding to the multispecific antibodies IgE-La2 and IgE-Lb4.J Comput Aided Mol Des1996https://conductscience.org/library/papers/8877702PubMed
8,794,290Proline-rich tandem repeats of antibody complementarity-determining regions bind and neutralize human immunodeficiency virus type 1 particles.J Virol1996https://conductscience.org/library/papers/8794290PubMed
8,643,580Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution.Proc Natl Acad Sci U S A1996https://conductscience.org/library/papers/8643580PubMed
8,455,724A designed metal-binding protein with a novel fold.Nature1993https://conductscience.org/library/papers/8455724PubMed

See all 102 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
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  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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