Paper4601807

T-cell-mediated immunopathology in viral infections.

Doherty PC and 1 other. Transplant Rev, 1974. Cited by 351 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. T-cell-mediated immunopathology in viral infections. Papers, record 4601807. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4601807

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: T-cell-mediated immunopathology in viral infections.; PubMed
Journal: Transplant Rev; PubMed
Year: 1974; PubMed
Publication types: Journal Article, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4601807/; PubMed
DOI: https://doi.org/10.1111/j.1600-065x.1974.tb00129.x; PubMed
The journal: https://conductscience.org/library/journal-index/0215244; PubMed
Citations, by iCite: 351; iCite
Relative citation ratio, by iCite: 7.03; iCite
Revised in PubMed: 2021-12-03; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Doherty PC	P C
2	Zinkernagel RM	R M

Source PubMed

Topics24

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Immunity, Cellular	Major topic
Lymphocytic Choriomeningitis	Major topic
Lymphocytic choriomeningitis virus	Major topic
T-Lymphocytes	Major topic
Animals
Antigen-Antibody Reactions
Antigens
B-Lymphocytes
Cerebrospinal Fluid
Chromium Radioisotopes
Complement System Proteins
Cortisone
Cyclophosphamide
Cytotoxicity Tests, Immunologic
Immune Sera
Immunosuppression Therapy
Inflammation
Meningitis, Listeria
Mice
Serum Albumin, Radio-Iodinated
Splenectomy
Time Factors
Transplantation, Homologous
Virus Diseases

Source PubMed

Show 18 more topicsShow fewer topics

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record
NCT01856205	Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis	Background

Source ClinicalTrials.gov

Cited by114

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 351 citations.

PMID	Title	Journal	Year	In Papers	Source
41,984,595	Variants in human CD48 lead to impaired T cell immunity and increased inflammation.	J Clin Invest	2026	https://conductscience.org/library/papers/41984595	PubMed
41,472,164	Identification of Regulators for Antigen-Specific CD8+ T Cells in African Swine Fever Virus-Restored Pigs.	Vet Sci	2025	https://conductscience.org/library/papers/41472164	PubMed
40,274,773	A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice.	Nat Commun	2025	https://conductscience.org/library/papers/40274773	PubMed
38,019,895	Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections.	PLoS Pathog	2023	https://conductscience.org/library/papers/38019895	PubMed
34,969,849	A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune-epithelial interface.	Proc Natl Acad Sci U S A	2022	https://conductscience.org/library/papers/34969849	PubMed
31,775,026	PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage.	Cell Rep	2019	https://conductscience.org/library/papers/31775026	PubMed
30,886,617	Local Antigen Encounter Is Essential for Establishing Persistent CD8+ T-Cell Memory in the CNS.	Front Immunol	2019	https://conductscience.org/library/papers/30886617	PubMed
30,691,215	Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries.	Viruses	2019	https://conductscience.org/library/papers/30691215	PubMed
28,448,566	IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.	PLoS Pathog	2017	https://conductscience.org/library/papers/28448566	PubMed
28,266,658	Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.	Sci Rep	2017	https://conductscience.org/library/papers/28266658	PubMed
25,393,615	T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.	Eur J Immunol	2015	https://conductscience.org/library/papers/25393615	PubMed
24,391,647	Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.	Front Immunol	2013	https://conductscience.org/library/papers/24391647	PubMed
21,820,469	Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever.	Antiviral Res	2011	https://conductscience.org/library/papers/21820469	PubMed
21,250,837	Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.	Autoimmunity	2011	https://conductscience.org/library/papers/21250837	PubMed
20,619,904	Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection.	J Neuroimmunol	2010	https://conductscience.org/library/papers/20619904	PubMed
20,401,700	Microbial induction of vascular pathology in the CNS.	J Neuroimmune Pharmacol	2010	https://conductscience.org/library/papers/20401700	PubMed
20,354,003	T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner.	Brain	2010	https://conductscience.org/library/papers/20354003	PubMed
20,164,414	CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.	J Immunol	2010	https://conductscience.org/library/papers/20164414	PubMed
19,828,618	Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation.	J Virol	2010	https://conductscience.org/library/papers/19828618	PubMed
19,515,766	Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production.	J Virol	2009	https://conductscience.org/library/papers/19515766	PubMed

Show 14 more cited byShow fewer cited bySee all 114 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

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Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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