Paper46267
Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response.
Murgita RA and 1 other. J Exp Med, 1975. Cited by 428 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response. Papers, record 46267. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/46267
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response.
- PubMed
Topics21
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Antibody Formation | Major topic |
| Fetal Proteins | Major topic |
| Immunosuppressive Agents | Major topic |
| Alpha-Globulins | |
| Amniotic Fluid | |
| Animals | |
| Antibody-Producing Cells | |
| Chromatography, Affinity | |
| Dose-Response Relationship, Drug | |
| Electrophoresis, Polyacrylamide Gel | |
| Hemolytic Plaque Technique | |
| Immunoglobulin A | |
| Immunoglobulin G | |
| Immunoglobulin M | |
| Mice | |
| Mice, Inbred BALB C | |
| Mice, Inbred CBA | |
| Serum Albumin | |
| Spleen | |
| Time Factors | |
| Transferrin |
Source PubMed
Grants1
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by |
|---|---|---|---|---|
| R01 HD017013 | NICHD NIH HHS | United States | R01HD017013 | PubMed |
Source NIH RePORTER
References52
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 4,878,356 | Embryonic constituents in tumors and antibodies in cancerous patients. | Curr Top Microbiol Immunol | 1968 | https://conductscience.org/library/papers/4878356 | PubMed |
| 2 | 6,051,394 | Characteristics of antibody response in young or thymectomized mice. | J Immunol | 1967 | https://conductscience.org/library/papers/6051394 | PubMed |
| 3 | 4,914,939 | Development of antibody-forming cells in neonatal mice: stimulation and inhibition by calf thymus fractions. | J Immunol | 1970 | https://conductscience.org/library/papers/4914939 | PubMed |
| 4 | 4,934,502 | Immune responses in vitro. 3. Development of primary gamma-M, gamma-G, and gamma-A plaque-forming cell responses in mouse spleen cell cultures stimulated with heterologous erythrocytes. | J Exp Med | 1971 | https://conductscience.org/library/papers/4934502 | PubMed |
| 5 | 4,971,842 | Selective enzyme purification by affinity chromatography. | Proc Natl Acad Sci U S A | 1968 | https://conductscience.org/library/papers/4971842 | PubMed |
| 6 | 4,996,792 | Deficient IgA antibody responses to arsanilic acid bovine serum albumin (BSA) in neonatally thymectomized rabbits. | J Immunol | 1971 | https://conductscience.org/library/papers/4996792 | PubMed |
| 7 | 5,010,391 | Quantitative estimation of antibody in the immunoglobulin classes of the mouse. II. Thymic dependence of the different classes. | J Immunol | 1972 | https://conductscience.org/library/papers/5010391 | PubMed |
| 9 | 13,936,401 | Ability of large doses of an alpha-2 plasma protein fraction to inhibit antibody production. | Immunology | 1963 | https://conductscience.org/library/papers/13936401 | PubMed |
| 10 | 14,010,646 | Production of embryonal alpha-globulin by transplantable mouse hepatomas. | Transplantation | 1963 | https://conductscience.org/library/papers/14010646 | PubMed |
| 11 | 14,113,507 | DEVELOPMENTAL CHANGES IN THE PLASMA PROTEIN PATTERN OF THE RAT. | Comp Biochem Physiol | 1963 | https://conductscience.org/library/papers/14113507 | PubMed |
| 12 | 14,234,745 | ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS. IV. IMMUNOGLOBULINS AND ANTIBODY FORMATION. | Int Arch Allergy Appl Immunol | 1964 | https://conductscience.org/library/papers/14234745 | PubMed |
| 13 | 14,240,533 | DISC ELECTROPHORESIS. I. BACKGROUND AND THEORY. | Ann N Y Acad Sci | 1964 | https://conductscience.org/library/papers/14240533 | PubMed |
| 14 | 14,240,539 | DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. | Ann N Y Acad Sci | 1964 | https://conductscience.org/library/papers/14240539 | PubMed |
| 15 | 4,103,410 | Serum inhibitors of lymphocyte responses. | Lancet | 1971 | https://conductscience.org/library/papers/4103410 | PubMed |
| 16 | 4,107,458 | Inhibition of secondary immune responses in vivo by immunoregulatory alpha globulin (IRA). | Proc Soc Exp Biol Med | 1971 | https://conductscience.org/library/papers/4107458 | PubMed |
| 17 | 4,107,670 | Alpha-fetoprotein in ontogenesis and its association with malignant tumors. | Adv Cancer Res | 1971 | https://conductscience.org/library/papers/4107670 | PubMed |
| 18 | 4,111,247 | Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy. | Lancet | 1972 | https://conductscience.org/library/papers/4111247 | PubMed |
| 19 | 4,117,204 | Serum-alpha-fetoprotein levels in patients with ataxia-telangiectasia. | Lancet | 1972 | https://conductscience.org/library/papers/4117204 | PubMed |
| 20 | 4,120,277 | "Spontaneous" B cell activation due to loss of normal mouse serum suppressor. | Eur J Immunol | 1972 | https://conductscience.org/library/papers/4120277 | PubMed |
| 21 | 4,133,780 | Rat alpha-fetoprotein: isolation, characterization and estrogen-binding properties. | Biochimie | 1973 | https://conductscience.org/library/papers/4133780 | PubMed |
Cited by53
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 428 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 38,222,505 | Advances and Challenges in Nanomaterial-Based Electrochemical Immunosensors for Small Cell Lung Cancer Biomarker Neuron-Specific Enolase. | ACS Omega | 2024 | https://conductscience.org/library/papers/38222505 | PubMed |
| 24,999,358 | Proteomic analysis of domestic pig pancreas during development using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry. | Lab Anim Res | 2014 | https://conductscience.org/library/papers/24999358 | PubMed |
| 23,435,332 | Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates. | Nat Rev Immunol | 2013 | https://conductscience.org/library/papers/23435332 | PubMed |
| 21,592,114 | α-Fetoprotein impairs activation of natural killer cells by inhibiting the function of dendritic cells. | Clin Exp Immunol | 2011 | https://conductscience.org/library/papers/21592114 | PubMed |
| 19,737,574 | Estrogen action: a historic perspective on the implications of considering alternative approaches. | Physiol Behav | 2010 | https://conductscience.org/library/papers/19737574 | PubMed |
| 18,612,221 | Alpha-fetoprotein, stem cells and cancer: how study of the production of alpha-fetoprotein during chemical hepatocarcinogenesis led to reaffirmation of the stem cell theory of cancer. | Tumour Biol | 2008 | https://conductscience.org/library/papers/18612221 | PubMed |
| 12,519,310 | Apoptosis-inducing protein derived from hepatocyte selectively induces apoptosis in lymphocytes. | Immunology | 2003 | https://conductscience.org/library/papers/12519310 | PubMed |
| 7,904,589 | Major histocompatibility complex restriction of maternally induced suppression in young adult mice. | Immunology | 1993 | https://conductscience.org/library/papers/7904589 | PubMed |
| 7,035,034 | Suppression of in vitro antibody response of human peripheral blood lymphocytes by a heat-labile factor in normal human serum. | Clin Exp Immunol | 1981 | https://conductscience.org/library/papers/7035034 | PubMed |
| 7,002,770 | Presence of a tumour-inhibiting factor (TIF) in sera from normal but not tumour-bearing mice. | Immunology | 1980 | https://conductscience.org/library/papers/7002770 | PubMed |
| 6,995,705 | Autoantibodies and serum inhibition factors (sif) in patients with myocarditis. | Klin Wochenschr | 1980 | https://conductscience.org/library/papers/6995705 | PubMed |
| 6,983,470 | Anti-albumin antibodies in sera of patients with liver disease. | Gastroenterol Jpn | 1982 | https://conductscience.org/library/papers/6983470 | PubMed |
| 6,934,536 | Immunosuppression by human plasma alpha 1-acid glycoprotein: importance of the carbohydrate moiety. | Proc Natl Acad Sci U S A | 1980 | https://conductscience.org/library/papers/6934536 | PubMed |
| 6,764,833 | Lymphocyte uropod inhibitory protein: an overview. | Surv Immunol Res | 1982 | https://conductscience.org/library/papers/6764833 | PubMed |
| 6,645,122 | Immunosuppressive acidic protein (IAP) in gastric cancer patients. | Jpn J Surg | 1983 | https://conductscience.org/library/papers/6645122 | PubMed |
| 6,190,602 | Response of human peripheral blood lymphocytes in the presence of cord sera: relationship of lymphocyte transformation with number of pregnancies and levels of alpha-fetoprotein. | Clin Exp Immunol | 1983 | https://conductscience.org/library/papers/6190602 | PubMed |
| 6,173,507 | Alphafetoprotein in congenital biliary atresia and neonatal hepatitis. | Jpn J Surg | 1981 | https://conductscience.org/library/papers/6173507 | PubMed |
| 6,161,275 | [Humoral factors in the regulation of cell proliferation in haematopoiesis. I. Granulopoiesis and lymphopoiesis (author's transl)]. | Klin Wochenschr | 1980 | https://conductscience.org/library/papers/6161275 | PubMed |
| 6,158,053 | Inhibitory effect of alpha-fetoprotein on the binding of myasthenia gravis antibody to acetylcholine receptor. | Proc Natl Acad Sci U S A | 1980 | https://conductscience.org/library/papers/6158053 | PubMed |
| 3,477,351 | Feto-maternal HLA compatibility does not have a major influence on human pregnancy except for lymphocytotoxin production. | Clin Exp Immunol | 1987 | https://conductscience.org/library/papers/3477351 | PubMed |
Genes3
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| AFP | 174 | PubTator's text mining | https://conductscience.org/library/genes/174 | NCBI Gene |
| ALB | 213 | PubTator's text mining | https://conductscience.org/library/genes/213 | NCBI Gene |
| TF | 7,018 | PubTator's text mining | https://conductscience.org/library/genes/7018 | NCBI Gene |
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Trials
- Comments and corrections
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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