Paper · 46924

Purification and characterization of the DNA polymerase and RNase H activities in Moloney murine sarcoma-leukemia virus.

Gerard GF and 1 other. J Virol, 1975. Cited by 69 papers, by iCite.

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ConductScience Library. Purification and characterization of the DNA polymerase and RNase H activities in Moloney murine sarcoma-leukemia virus. Papers, record 46924. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/46924

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Purification and characterization of the DNA polymerase and RNase H activities in Moloney murine sarcoma-leukemia virus.; PubMed
Journal: J Virol; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/46924/; PubMed
DOI: https://doi.org/10.1128/jvi.15.4.785-797.1975; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC354521/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 69; iCite
Relative citation ratio, by iCite: 1.51; iCite
Revised in PubMed: 2020-07-24; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Gerard GF	G F
2	Grandgenett DP	D P

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Moloney murine leukemia virus	Major topic
RNA-Directed DNA Polymerase	Major topic
Ribonucleases	Major topic
Avian Leukosis Virus
Centrifugation, Density Gradient
Chromatography
Chromatography, Gel
Genetic Complementation Test
Magnesium
Manganese
Molecular Weight
Nucleic Acid Hybridization
Polynucleotides
Transcription, Genetic
Tritium

Source PubMed

Grants0

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None in this release.

Trials0

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None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,134,616	Separation of ribonuclease H and RNA directed DNA polymerase (reverse transcriptase) of murine type-C RNA tumor viruses.	Proc Natl Acad Sci U S A	1974	https://conductscience.org/library/papers/4134616	PubMed
2	4,135,976	RNA-directed DNA polymerase--properties and functions in oncogenic RNA viruses and cells.	Prog Nucleic Acid Res Mol Biol	1974	https://conductscience.org/library/papers/4135976	PubMed
3	4,136,633	Different mode of action of ribonuclease H in purified alpha and alpha beta ribonucleic acid-directed deoxyribonucleic acid polymerase from avian myeloblastosis virus.	J Biol Chem	1974	https://conductscience.org/library/papers/4136633	PubMed
4	4,137,174	RNA-dependent DNA polymerase and ribonuclease H from Friend virions.	FEBS Lett	1974	https://conductscience.org/library/papers/4137174	PubMed
5	4,137,615	DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile.	Nature	1974	https://conductscience.org/library/papers/4137615	PubMed
6	4,318,786	Mechanism of carcinogenesis by RNA tumor viruses. I. An RNA-dependent DNA polymerase in murine sarcoma viruses.	Proc Natl Acad Sci U S A	1970	https://conductscience.org/library/papers/4318786	PubMed
7	4,322,157	RNA-dependent DNA polymerase activity in five RNA viruses: divalent cation requirements.	Proc Natl Acad Sci U S A	1970	https://conductscience.org/library/papers/4322157	PubMed
8	4,338,254	Viral RNA subunits in cells transformed by RNA tumor viruses.	Science	1972	https://conductscience.org/library/papers/4338254	PubMed
9	4,343,966	Degradation of DNA RNA hybrids by ribonuclease H and DNA polymerases of cellular and viral origin.	Proc Natl Acad Sci U S A	1972	https://conductscience.org/library/papers/4343966	PubMed
10	4,357,518	DNA polymerase of murine sarcoma-leukemia virus: lack of detectable RNase H and low activity with viral RNA and natural DNA templates.	J Virol	1973	https://conductscience.org/library/papers/4357518	PubMed

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Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 69 citations.

PMID	Title	Journal	Year	In Papers	Source
41,327,310	Functions and applications of enzymes in nucleic acid nanotechnology.	J Nanobiotechnology	2025	https://conductscience.org/library/papers/41327310	PubMed
34,994,918	Ribozyme Mutagenic Evolution: Mechanisms of Survival.	Orig Life Evol Biosph	2021	https://conductscience.org/library/papers/34994918	PubMed
33,778,250	Quick and Easy Assembly of a One-Step qRT-PCR Kit for COVID-19 Diagnostics Using In-House Enzymes.	ACS Omega	2021	https://conductscience.org/library/papers/33778250	PubMed
28,160,599	Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptase.	Nucleic Acids Res	2017	https://conductscience.org/library/papers/28160599	PubMed
19,814,799	Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains.	Virol J	2009	https://conductscience.org/library/papers/19814799	PubMed
12,136,094	The role of template-primer in protection of reverse transcriptase from thermal inactivation.	Nucleic Acids Res	2002	https://conductscience.org/library/papers/12136094	PubMed
11,716,355	Insertion of a peptide from MuLV RT into the connection subdomain of HIV-1 RT results in a functionally active chimeric enzyme in monomeric conformation.	Mol Cell Biochem	2001	https://conductscience.org/library/papers/11716355	PubMed
9,658,093	Human T-cell leukemia virus type 1 reverse transcriptase (RT) originates from the pro and pol open reading frames and requires the presence of RT-RNase H (RH) and RT-RH-integrase proteins for its activity.	J Virol	1998	https://conductscience.org/library/papers/9658093	PubMed
7,506,526	Sulphydryl groups in the template-primer-binding domain of murine leukaemia virus reverse transcriptase. Identification and functional analysis of cysteine-90.	Biochem J	1993	https://conductscience.org/library/papers/7506526	PubMed
6,163,872	Mechanism of action of Moloney murine leukemia virus RNase H III.	J Virol	1981	https://conductscience.org/library/papers/6163872	PubMed

1 to 10 of 27

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None in this release.

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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