Paper · 47219

The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

Shreffler DC and 1 other. Adv Immunol, 1975. Cited by 449 papers, by iCite.

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ConductScience Library. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Papers, record 47219. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/47219

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.; PubMed
Journal: Adv Immunol; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/47219/; PubMed
DOI: https://doi.org/10.1016/s0065-2776(08)60208-4; PubMed
The journal: https://conductscience.org/library/journal-index/0370425; PubMed
Citations, by iCite: 449; iCite
Relative citation ratio, by iCite: 11.6; iCite
Revised in PubMed: 2019-10-27; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Shreffler DC	D C
2	David CS	C S

Source PubMed

Topics24

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antibody Formation	Major topic
Histocompatibility Antigens	Major topic
Terminology as Topic	Major topic
Alleles
Animals
Antibody Specificity
B-Lymphocytes
Chromium Radioisotopes
Chromosome Mapping
Cytotoxicity Tests, Immunologic
Epitopes
Genes, Dominant
Graft Rejection
Graft vs Host Reaction
Immune Sera
Immunogenetics
Lymphocyte Culture Test, Mixed
Mice
Mutation
Oncogenic Viruses
Recombination, Genetic
Skin Transplantation
T-Lymphocytes
Transplantation, Isogeneic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by179

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 449 citations.

PMID	Title	Journal	Year	In Papers	Source
37,726,420	Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing.	Cell Mol Immunol	2023	https://conductscience.org/library/papers/37726420	PubMed
24,254,171	Effects of marked chromosome sections on milk performance in cattle.	Theor Appl Genet	1985	https://conductscience.org/library/papers/24254171	PubMed
22,457,929	Activation or suppression of bactericidal activity of macrophages during a graft-versus-host reaction against I-A and I-J-region differences, respectively.	Immunogenetics	1980	https://conductscience.org/library/papers/22457929	PubMed
22,457,918	Identification of two Ia-like alloantigens on rabbit B lymphocytes.	Immunogenetics	1980	https://conductscience.org/library/papers/22457918	PubMed
21,665,435	To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.	J Autoimmun	2011	https://conductscience.org/library/papers/21665435	PubMed
21,302,102	The major histocompatibility complex of the rat,RT1 : I. serological characterization of the MNR haplotype (RT1 ( m )) in regard to the cross-reacting haplotypesRT1 ( a ),RT1 ( c ), andRT1 ( b ).	Immunogenetics	1978	https://conductscience.org/library/papers/21302102	PubMed
21,302,100	Expression of ia antigens by murine keratinizing epithelial langerhans cells.	Immunogenetics	1978	https://conductscience.org/library/papers/21302100	PubMed
21,302,097	Partial amino acid sequences of mouse transplantation antigens.	Immunogenetics	1978	https://conductscience.org/library/papers/21302097	PubMed
21,302,095	Intra-H-2 recombination inH-2(b)/H-2 (t1) heterozygotes in the mouse : II. Characterization of recombinant haplotypesat2, at3, andat4.	Immunogenetics	1978	https://conductscience.org/library/papers/21302095	PubMed
21,302,085	TheH-2L locus and the system of H-2 specificities.	Immunogenetics	1978	https://conductscience.org/library/papers/21302085	PubMed

1 to 10 of 179

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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