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Paper · 4733239

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.

Bolton AE and 1 other. Biochem J, 1973. Cited by 3,415 papers, by iCite.

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ConductScience Library. The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Papers, record 4733239. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4733239

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.
PubMed
Journal
Biochem J
PubMed
Year
1973
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
3,415
iCite
Relative citation ratio, by iCite
90.2
iCite
Revised in PubMed
2020-12-31
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Bolton AEA E
2Hunter WMW M

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Chemistry, OrganicMajor topic
Iodine IsotopesMajor topic
ProteinsMajor topic
Acylation
Chloramines
Esters
Growth Hormone
Humans
Immune Sera
Luteinizing Hormone
Methods
Organic Chemistry Phenomena
Oxidation-Reduction
Propionates
Radioimmunoassay
Succinimides
Thyrotropin
Tyrosine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,475,952Immunoassay of insulin using a two-antibody system.Proc Soc Exp Biol Med1962https://conductscience.org/library/papers/14475952PubMed
25,565,609Mathematical analysis of kinetics of radioligand assays: improved sensitivity obtained by delayed addition of labeled ligand.J Clin Endocrinol Metab1971https://conductscience.org/library/papers/5565609PubMed
35,170,158Use of lactoperoxidase catalyzed iodination in immunochemical studies.Immunochemistry1971https://conductscience.org/library/papers/5170158PubMed
45,288,373Insulin--receptor interactions in adipose tissue cells: direct measurement and properties.Proc Natl Acad Sci U S A1971https://conductscience.org/library/papers/5288373PubMed
613,745,950Trace-labelling of insulin with iodine.Nature1961https://conductscience.org/library/papers/13745950PubMed
711,452,877Enzymatic iodination of polypeptides with 125I to high specific activity.Biochim Biophys Acta1971https://conductscience.org/library/papers/11452877PubMed
813,952,078Immunoassay of insulin with insulin-antibody precipitate.Biochem J1963https://conductscience.org/library/papers/13952078PubMed
914,450,081Preparation of iodine-131 labelled human growth hormone of high specific activity.Nature1962https://conductscience.org/library/papers/14450081PubMed
1016,742,792Appendix: Preparation of N-succinimidyl 3-(4-hydroxyphenyl)propionate.Biochem J1973https://conductscience.org/library/papers/16742792PubMed
115,463,909Assessment of damage to I-131-labeled parathyroid hormone by chromatoelectrophoresis and adsorption onto dextran-charcoal.J Lab Clin Med1970https://conductscience.org/library/papers/5463909PubMed

1 to 10 of 21

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Cited by633

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3,415 citations.

PMIDTitleJournalYearIn PapersSource
41,430,699Comparative permeability of the blood-brain barrier to albumin, DTPA, and sucrose: effects of inflammation-induced disruption.Fluids Barriers CNS2025https://conductscience.org/library/papers/41430699PubMed
40,293,448Radiolabeling lipoproteins to study and manage disease.Eur J Nucl Med Mol Imaging2025https://conductscience.org/library/papers/40293448PubMed
38,446,323MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates.Mol Imaging Biol2024https://conductscience.org/library/papers/38446323PubMed
38,145,968X-Ray Visible Protein Scaffolds by Bulk Iodination.Adv Sci (Weinh)2024https://conductscience.org/library/papers/38145968PubMed
37,967,285Precursor Reagent Hydrophobicity Affects Membrane Protein Footprinting.J Am Soc Mass Spectrom2023https://conductscience.org/library/papers/37967285PubMed
36,430,267Synthesis of Radioiodinated Compounds. Classical Approaches and Achievements of Recent Years.Int J Mol Sci2022https://conductscience.org/library/papers/36430267PubMed
36,314,010Immuno-PET: Design options and clinical proof-of-concept.Front Med (Lausanne)2022https://conductscience.org/library/papers/36314010PubMed
35,745,855A Historical Review of Brain Drug Delivery.Pharmaceutics2022https://conductscience.org/library/papers/35745855PubMed
33,925,081In Vitro Cytotoxicity of Trastuzumab (Tz) and Se-Trastuzumab (Se-Tz) against the Her/2 Breast Cancer Cell Lines JIMT-1 and BT-474.Int J Mol Sci2021https://conductscience.org/library/papers/33925081PubMed
33,466,827Radiochemistry, Production Processes, Labeling Methods, and ImmunoPET Imaging Pharmaceuticals of Iodine-124.Molecules2021https://conductscience.org/library/papers/33466827PubMed

1 to 10 of 633

See all 633 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
GH12,688PubTator's text mininghttps://conductscience.org/library/genes/2688

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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