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Paper47899

The mechanism of tolerance induction in thymus-derived lymphocytes; I. intracellular inactivation of hapten-reactive helper T lymphocytes by hapten-nonimmunogenic copolymer of D-amino acids.

Hamaoka T and 3 others. J Exp Med, 1975. Cited by 22 papers, by iCite.

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ConductScience Library. The mechanism of tolerance induction in thymus-derived lymphocytes; I. intracellular inactivation of hapten-reactive helper T lymphocytes by hapten-nonimmunogenic copolymer of D-amino acids. Papers, record 47899. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/47899

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The mechanism of tolerance induction in thymus-derived lymphocytes; I. intracellular inactivation of hapten-reactive helper T lymphocytes by hapten-nonimmunogenic copolymer of D-amino acids.
PubMed
Journal
J Exp Med
PubMed
Year
1975
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
22
iCite
Relative citation ratio, by iCite
0.53
iCite
Revised in PubMed
2019-05-08
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Hamaoka TT
2Yamaskita UU
3Takami TT
4Kitagawa MM

Source PubMed

Topics24

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carrier ProteinsMajor topic
HaptensMajor topic
Immune ToleranceMajor topic
T-LymphocytesMajor topic
Amylases
Animals
Antibody Formation
Antibody-Producing Cells
Azo Compounds
Benzoates
Binding Sites, Antibody
Cell Membrane
Complement System Proteins
Freund's Adjuvant
Glutamates
Hemocyanins
Immune Sera
Immunization Schedule
Immunization, Passive
Lysine
Mice
Peptides
Trypsin
gamma-Globulins

Source PubMed

References29

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
113,836,501Azoproteins. II. A spectrophotometric study of the coupling of diazotized arsanilic acid with proteins.J Biol Chem1960https://conductscience.org/library/papers/13836501PubMed
24,101,345Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses.J Exp Med1970https://conductscience.org/library/papers/4101345PubMed
34,110,123Cellular cooperation in the antibody response of mice to two serum albumins: specific function of thymus cells.Transplant Rev1969https://conductscience.org/library/papers/4110123PubMed
44,116,319The regulatory influence of activated T cells on B cell responses to antigen.Adv Immunol1972https://conductscience.org/library/papers/4116319PubMed
54,117,341Inhibition of secondary anti-hapten responses with the hapten conjugated to type 3 pneumococcal polysaccharide.Eur J Immunol1972https://conductscience.org/library/papers/4117341PubMed
64,117,564Effect of immunological unresponsiveness on different cell populations.Transplant Rev1972https://conductscience.org/library/papers/4117564PubMed
74,126,726Induction of immunological tolerance in bone marrow-derived lymphocytes of the IgE antibody class.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4126726PubMed
84,130,110
Failure to induce tolerance to 2,4-dinitrochlorobenzene contact sensitivity with a 2,4-dinitrophenyl (DNP) conjugate of a copolymer of D-glutamic acid and D-lysine, a specific tolerogen for DNP B cells.
J Immunol1974https://conductscience.org/library/papers/4130110PubMed
94,133,614
Immunological tolerance in bone marrow-derived lymphocytes. II. Effects of allogeneic cell interactions and enzymatic digestion with trypsin or inactivated hapten-specific precursors of antibody-forming cells.
J Exp Med1974https://conductscience.org/library/papers/4133614PubMed
104,137,682Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT).J Exp Med1974https://conductscience.org/library/papers/4137682PubMed
114,143,108Induction of anti-hapten antibody response by hapten-isologous carrier conjugate. I. Development of hapten-reactive helper cells by hapten-isologous carrier.Cell Immunol1974https://conductscience.org/library/papers/4143108PubMed
124,153,121
The immunological properties of haptens coupled to thymus-independent carrier molecules. I. The characteristics of the immune response to dinitrophenyl-lysine-substituted pneumococcal polysaccharide (SIII) and levan.
Eur J Immunol1974https://conductscience.org/library/papers/4153121PubMed
134,159,035Role of the thymus in tolerance. I. Tolerance to bovine gamma globulin in thymectomized, irradiated rats grafted with thymus from tolerant donors.J Exp Med1965https://conductscience.org/library/papers/4159035PubMed
144,301,109Immune paralysis of thymus cells by bovine serum albumin.Nature1968https://conductscience.org/library/papers/4301109PubMed
154,354,892Cellular events in tolerance. I. Failure to demonstrate activation of lymphocytes, blocking factors, or suppressor cells during the induction of tolerance to a soluble protein.J Immunol1973https://conductscience.org/library/papers/4354892PubMed
164,397,662
Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.
J Exp Med1971https://conductscience.org/library/papers/4397662PubMed
174,539,013Radioresistance of carrier-specific helper thymus-derived lymphocytes in mice.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4539013PubMed
184,539,311Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells.J Exp Med1972https://conductscience.org/library/papers/4539311PubMed
194,539,833Hapten-specific tolerance: depressed humoral and normal cellular immune responses.J Immunol1973https://conductscience.org/library/papers/4539833PubMed
204,545,896Cell-to-cell interaction in the immune response. X. T-cell-dependent suppression in tolerant mice.J Exp Med1974https://conductscience.org/library/papers/4545896PubMed

See all 29 references

Cited by5

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 22 citations.

PMIDTitleJournalYearIn PapersSource
1,085,283Preferential generation of killer or helper T-lymphocyte activity directed to the tumour-associated transplantation antigens.Immunology1976https://conductscience.org/library/papers/1085283PubMed
310,858
Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. III. Amplification of a generation of tumor-specific killer T-lymphocyte activities by suppressor T-cell-depleted hapten-reactive T lymphocytes.
J Exp Med1979https://conductscience.org/library/papers/310858PubMed
109,567Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. I. Genetic control of delayed-type hypersensitivity by VH and I-A-region genes.J Exp Med1979https://conductscience.org/library/papers/109567PubMed
68,995
Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. II. Selective inactivation of hapten-reactive suppressor T cells by hapten-nonimmunogenic copolymers of D-amino acids, and its application to the study of suppressor T-cell effect on helper T-cell development.
J Exp Med1977https://conductscience.org/library/papers/68995PubMed
68,994
Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. I. Detection and characterization of hapten-reactive suppressor T-cell activity in mice immunized with hapten-isologous protein conjugate.
J Exp Med1977https://conductscience.org/library/papers/68994PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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