Paper · 47901

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

Zinkernagel RM and 1 other. J Exp Med, 1975. Cited by 664 papers, by iCite.

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ConductScience Library. H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;. Papers, record 47901. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/47901

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.; PubMed
Journal: J Exp Med; PubMed
Year: 1975; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/47901/; PubMed
DOI: https://doi.org/10.1084/jem.141.6.1427; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2189841/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 664; iCite
Relative citation ratio, by iCite: 14; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Zinkernagel RM	R M
2	Doherty PC	P C

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Epitopes	Major topic
Histocompatibility Antigens	Major topic
Lymphocytic choriomeningitis virus	Major topic
T-Lymphocytes	Major topic
Animals
Antibody Formation
Chromium Radioisotopes
Cytotoxicity Tests, Immunologic
Genotype
Injections, Intravenous
Macrophages
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred CBA
Radiation Effects
Recombination, Genetic
Spleen

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References19

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,078,677	Capacity of sensitized thymus-derived lymphocytes to induce fatal lymphocytic choriomeningitis is restricted by the H-2 gene complex.	J Immunol	1975	https://conductscience.org/library/papers/1078677	PubMed
2	123,002	H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.	J Exp Med	1975	https://conductscience.org/library/papers/123002	PubMed
3	14,978,855	The somatic generation of immune recognition.	Eur J Immunol	1971	https://conductscience.org/library/papers/14978855	PubMed
4	4,108,876	The H-2 model for the major histocompatibility systems.	Transplant Rev	1971	https://conductscience.org/library/papers/4108876	PubMed
5	4,113,158	Evolutionary significance of the HL-A system.	Nature	1972	https://conductscience.org/library/papers/4113158	PubMed
6	4,122,709	Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.	J Exp Med	1973	https://conductscience.org/library/papers/4122709	PubMed
7	4,126,264	Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions.	Proc Natl Acad Sci U S A	1973	https://conductscience.org/library/papers/4126264	PubMed
8	4,129,963	Cell-mediated immunity to bacterial infection in the mouse. Thymus-derived cells as effectors of acquired resistance to Listeria monocytogenes.	Scand J Immunol	1972	https://conductscience.org/library/papers/4129963	PubMed
9	4,133,807	Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.	Nature	1974	https://conductscience.org/library/papers/4133807	PubMed
10	4,151,339	Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.	Adv Immunol	1974	https://conductscience.org/library/papers/4151339	PubMed

1 to 10 of 19

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Cited by174

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 664 citations.

PMID	Title	Journal	Year	In Papers	Source
41,087,899	Inbreeding does not reduce major histocompatibility complex diversity in the banded mongoose.	BMC Ecol Evol	2025	https://conductscience.org/library/papers/41087899	PubMed
36,091,060	Wnt5A signaling supports antigen processing and CD8 T cell activation.	Front Immunol	2022	https://conductscience.org/library/papers/36091060	PubMed
34,452,376	The Interplay between Bluetongue Virus Infections and Adaptive Immunity.	Viruses	2021	https://conductscience.org/library/papers/34452376	PubMed
32,286,171	How Basic Immunological Principles May Instruct the Design of a Successful HIV-Type 1 Vaccine.	Viral Immunol	2020	https://conductscience.org/library/papers/32286171	PubMed
30,691,215	Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries.	Viruses	2019	https://conductscience.org/library/papers/30691215	PubMed
30,374,353	2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes.	Front Immunol	2018	https://conductscience.org/library/papers/30374353	PubMed
26,269,172	Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.	J Virol	2015	https://conductscience.org/library/papers/26269172	PubMed
26,099,694	Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity.	Virology	2015	https://conductscience.org/library/papers/26099694	PubMed
25,818,864	Codification of bidentate pMHC interaction with TCR and its co-receptor.	Trends Immunol	2015	https://conductscience.org/library/papers/25818864	PubMed
25,155,903	Modeling the T cell immune response: a fascinating challenge.	J Pharmacokinet Pharmacodyn	2014	https://conductscience.org/library/papers/25155903	PubMed

1 to 10 of 174

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Genes0

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None in this release.

Drugs0

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Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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