Paper · 49105

The theory of the 'one nonspecific signal' model for b cell activation.

Coutinho A. Transplant Rev, 1975. Cited by 66 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The theory of the 'one nonspecific signal' model for b cell activation. Papers, record 49105. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/49105

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The theory of the 'one nonspecific signal' model for b cell activation.; PubMed
Journal: Transplant Rev; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/49105/; PubMed
DOI: https://doi.org/10.1111/j.1600-065x.1975.tb00148.x; PubMed
The journal: https://conductscience.org/library/journal-index/0215244; PubMed
Citations, by iCite: 66; iCite
Relative citation ratio, by iCite: 1.22; iCite
Revised in PubMed: 2019-10-27; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Coutinho A	A

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocytes	Major topic
Lymphocyte Activation	Major topic
Animals
Antibody Formation
Antibody-Producing Cells
Antigen-Antibody Reactions
Binding Sites, Antibody
Cell Membrane
Epitopes
Humans
Immune Tolerance
Phenotype
T-Lymphocytes

Source PubMed

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Comments and corrections0

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References0

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Cited by16

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 66 citations.

PMID	Title	Journal	Year	In Papers	Source
8,685,952	Tacrolimus pretreatment attenuates preexisting xenospecific immunity and abrogates hyperacute rejection in a presensitized hamster to rat liver transplant model.	Transplantation	1996	https://conductscience.org/library/papers/8685952	PubMed
6,168,024	The polyclonal expression of immunoglobulin variable region determinants on the membrane of B cells and their precursors.	Springer Semin Immunopathol	1980	https://conductscience.org/library/papers/6168024	PubMed
6,167,364	A general interactive model for B cell activation II. Experimental verification.	Cell Biophys	1981	https://conductscience.org/library/papers/6167364	PubMed
6,167,363	A general interactive model for B cell activation. I. The theory.	Cell Biophys	1981	https://conductscience.org/library/papers/6167363	PubMed
3,292,672	Studies of surface immunoglobulin-dependent B cell activation.	Immunol Res	1988	https://conductscience.org/library/papers/3292672	PubMed
1,244,416	Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS.	J Exp Med	1976	https://conductscience.org/library/papers/1244416	PubMed
1,083,830	Role of membrane structures in B-lymphocyte activation. The effect of binding anti-immunoglobulin, aggregated IgG and immune complexes.	Immunology	1976	https://conductscience.org/library/papers/1083830	PubMed
786,253	Immunocompetent cells in resistance to bacterial infections.	Bacteriol Rev	1976	https://conductscience.org/library/papers/786253	PubMed
391,701	Anti-DNP antibody responses to DNP-histone H1 in mice.	Immunology	1979	https://conductscience.org/library/papers/391701	PubMed
324,900	Heteroantisera prepared against B lymphocytes at different stages of differentiation. II. Functional analysis of cytotoxicity to different B-cell populations.	Immunology	1977	https://conductscience.org/library/papers/324900	PubMed

1 to 10 of 16

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Drugs0

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Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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