Paper49390
RNA-instructed DNA polymerase activity in a cytoplasmic particulate fraction in brains from Guamanian patients.
Viola MV and 4 others. J Exp Med, 1975. Cited by 53 papers, by iCite.
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ConductScience Library. RNA-instructed DNA polymerase activity in a cytoplasmic particulate fraction in brains from Guamanian patients. Papers, record 49390. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/49390
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- RNA-instructed DNA polymerase activity in a cytoplasmic particulate fraction in brains from Guamanian patients.
- PubMed
Topics16
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Amyotrophic Lateral Sclerosis | Major topic |
| Brain | Major topic |
| Cytoplasm | Major topic |
| Parkinson Disease | Major topic |
| RNA-Directed DNA Polymerase | Major topic |
| Autopsy | |
| Brain Chemistry | |
| Cell Fractionation | |
| Centrifugation, Density Gradient | |
| DNA | |
| Humans | |
| Nucleic Acid Hybridization | |
| RNA | |
| Rauscher Virus | |
| Tritium | |
| Visna-maedi virus |
Source PubMed
References31
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,055,389 | Definitive evidence that the murine C-type virus inducing locus Akv-1 is viral genetic material. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1055389 | PubMed |
| 3 | 13,776,692 | An electron microscope study of tissue cultures infected with visna virus. | Virology | 1961 | https://conductscience.org/library/papers/13776692 | PubMed |
| 4 | 14,290,352 | SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA. | J Mol Biol | 1965 | https://conductscience.org/library/papers/14290352 | PubMed |
| 5 | 4,097,496 | Characteristics of cores of avian leuko-sarcoma viruses. | Virology | 1970 | https://conductscience.org/library/papers/4097496 | PubMed |
| 6 | 4,112,071 | Surface-active agents for isolation of the core component of avian myeloblastosis virus. | J Virol | 1972 | https://conductscience.org/library/papers/4112071 | PubMed |
| 7 | 4,120,713 | Conditions for the selective synthesis of DNA complementary to template RNA. | Biochim Biophys Acta | 1973 | https://conductscience.org/library/papers/4120713 | PubMed |
| 8 | 4,124,682 | Further evidence for oncornaviruses in human milk: the production of cores. | Proc Natl Acad Sci U S A | 1973 | https://conductscience.org/library/papers/4124682 | PubMed |
| 9 | 4,127,186 | Demonstration of a DNA provirus in the lytic growth of visna virus. | Nat New Biol | 1973 | https://conductscience.org/library/papers/4127186 | PubMed |
| 10 | 4,131,745 | Primate RNA tumor virus-like DNA synthesized endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood cells. | Proc Natl Acad Sci U S A | 1973 | https://conductscience.org/library/papers/4131745 | PubMed |
| 11 | 4,133,312 | DNA-direced and RNA-primed DNA synthesis in microsomal and mitochondrial fractions of normal human lymphocytes. | Biochem Biophys Res Commun | 1974 | https://conductscience.org/library/papers/4133312 | PubMed |
| 12 | 4,218,241 | Amyotrophic lateral sclerosis, Parkinson's disease, and the amyotrophic lateral sclerosis-Parkinsonism-dementia complex on Guam: a review and summary of attempts to demonstrate infection as the aetiology. | J Clin Pathol Suppl (R Coll Pathol) | 1972 | https://conductscience.org/library/papers/4218241 | PubMed |
| 13 | 4,317,810 | DNA-directed DNA polymerase activity in oncogenic RNA viruses. | Nature | 1970 | https://conductscience.org/library/papers/4317810 | PubMed |
| 14 | 4,330,470 | Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses. | Science | 1971 | https://conductscience.org/library/papers/4330470 | PubMed |
| 15 | 4,340,747 | Detection of RNA-instructed DNA polymerase and high molecular weight RNA in malignant tissue. | Proc Natl Acad Sci U S A | 1972 | https://conductscience.org/library/papers/4340747 | PubMed |
| 16 | 4,354,228 | Isolation of a neurotropic type C virus. | Science | 1973 | https://conductscience.org/library/papers/4354228 | PubMed |
| 17 | 4,355,605 | A spontaneous lower motor neuron disease apparently caused by indigenous type-C RNA virus in wild mice. | J Natl Cancer Inst | 1973 | https://conductscience.org/library/papers/4355605 | PubMed |
| 18 | 4,512,842 | Particulate form of DNA polymerase in rat brain. | Nat New Biol | 1972 | https://conductscience.org/library/papers/4512842 | PubMed |
| 19 | 4,561,643 | An appraisal of the neurotoxicity of cycad and the etiology of amyotrophic lateral sclerosis on Guam. | Fed Proc | 1972 | https://conductscience.org/library/papers/4561643 | PubMed |
| 20 | 4,631,425 | Polyadenylic acid in Visna virus RNA. | Science | 1973 | https://conductscience.org/library/papers/4631425 | PubMed |
| 21 | 4,669,196 | Epidemiologic features of amyotropic lateral sclerosis and parkinsonism-dementia in Guam, Mariana Islands. | Int J Epidemiol | 1972 | https://conductscience.org/library/papers/4669196 | PubMed |
Cited by27
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 53 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 41,830,063 | HML-2 env knockdown by AAV9-mediated miRNAs attenuates amyotrophic lateral sclerosis-like manifestations in mice. | Brain | 2026 | https://conductscience.org/library/papers/41830063 | PubMed |
| 37,990,347 | Proceedings of the inaugural Dark Genome Symposium: November 2022. | Mob DNA | 2023 | https://conductscience.org/library/papers/37990347 | PubMed |
| 37,872,387 | Activation of human endogenous retroviruses and its physiological consequences. | Nat Rev Mol Cell Biol | 2024 | https://conductscience.org/library/papers/37872387 | PubMed |
| 37,450,244 | The Molecular Link Between TDP-43, Endogenous Retroviruses and Inflammatory Neurodegeneration in Amyotrophic Lateral Sclerosis: a Potential Target for Triumeq, an Antiretroviral Therapy. | Mol Neurobiol | 2023 | https://conductscience.org/library/papers/37450244 | PubMed |
| 36,077,510 | Transcriptional Regulation of Endogenous Retroviruses and Their Misregulation in Human Diseases. | Int J Mol Sci | 2022 | https://conductscience.org/library/papers/36077510 | PubMed |
| 36,053,951 | Antibody Response to HML-2 May Be Protective in Amyotrophic Lateral Sclerosis. | Ann Neurol | 2022 | https://conductscience.org/library/papers/36053951 | PubMed |
| 35,771,941 | Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition. | Proc Natl Acad Sci U S A | 2022 | https://conductscience.org/library/papers/35771941 | PubMed |
| 35,415,778 | Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis. | Neurotherapeutics | 2022 | https://conductscience.org/library/papers/35415778 | PubMed |
| 34,320,928 | Targeted immune epitope prediction to HHLA2 and MAGEB5 protein variants as therapeutic approach to related viral diseases. | BMC Immunol | 2021 | https://conductscience.org/library/papers/34320928 | PubMed |
| 33,653,604 | Inhibition of HERV-K (HML-2) in amyotrophic lateral sclerosis patients on antiretroviral therapy. | J Neurol Sci | 2021 | https://conductscience.org/library/papers/33653604 | PubMed |
| 32,628,265 | Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia. | Hum Mol Genet | 2020 | https://conductscience.org/library/papers/32628265 | PubMed |
| 31,695,598 | Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner. | Front Cell Neurosci | 2019 | https://conductscience.org/library/papers/31695598 | PubMed |
| 31,362,360 | Expression of HERV Genes as Possible Biomarker and Target in Neurodegenerative Diseases. | Int J Mol Sci | 2019 | https://conductscience.org/library/papers/31362360 | PubMed |
| 30,318,978 | Human endogenous retrovirus-K (HML-2): a comprehensive review. | Crit Rev Microbiol | 2018 | https://conductscience.org/library/papers/30318978 | PubMed |
| 29,806,531 | Acute onset of bulbar amyotrophic lateral sclerosis after flu - look at the differential diagnosis: A case report. | J Int Med Res | 2018 | https://conductscience.org/library/papers/29806531 | PubMed |
| 29,551,251 | Human Endogenous Retroviruses in Neurological Diseases. | Trends Mol Med | 2018 | https://conductscience.org/library/papers/29551251 | PubMed |
| 28,800,335 | An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge? | J Alzheimers Dis | 2017 | https://conductscience.org/library/papers/28800335 | PubMed |
| 27,664,983 | HIV-associated motor neuron disease: HERV-K activation and response to antiretroviral therapy. | Neurology | 2016 | https://conductscience.org/library/papers/27664983 | PubMed |
| 27,110,325 | Redox Imbalance and Viral Infections in Neurodegenerative Diseases. | Oxid Med Cell Longev | 2016 | https://conductscience.org/library/papers/27110325 | PubMed |
| 26,424,568 | Human endogenous retrovirus-K contributes to motor neuron disease. | Sci Transl Med | 2015 | https://conductscience.org/library/papers/26424568 | PubMed |
Data dates
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- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Grants
- Trials
- Comments and corrections
- Genes
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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