Paper · 5317954

The relative efficacy of guanethidine, methyldopa and pargyline as antihypertensive agents.

Oates JA and 4 others. N Engl J Med, 1965. Cited by 63 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The relative efficacy of guanethidine, methyldopa and pargyline as antihypertensive agents. Papers, record 5317954. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/5317954

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The relative efficacy of guanethidine, methyldopa and pargyline as antihypertensive agents.; PubMed
Journal: N Engl J Med; PubMed
Year: 1965; PubMed
Publication types: Clinical Trial, Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/5317954/; PubMed
DOI: https://doi.org/10.1056/nejm196509302731402; PubMed
The journal: https://conductscience.org/library/journal-index/0255562; PubMed
Citations, by iCite: 63; iCite
Revised in PubMed: 2013-11-21; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Oates JA	J A
2	Seligmann AW	A W
3	Clark MA	M A
4	Rousseau P	P
5	Lee RE	R E

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Guanethidine	Major topic
Hypertension	Major topic
Methyldopa	Major topic
Pargyline	Major topic
Clinical Trials as Topic
Humans
Hypotension, Orthostatic

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 63 citations.

PMID	Title	Journal	Year	In Papers	Source
30,255,284	A reassessment of the safety profile of monoamine oxidase inhibitors: elucidating tired old tyramine myths.	J Neural Transm (Vienna)	2018	https://conductscience.org/library/papers/30255284	PubMed
20,919,347	Problems with Beta Adrenergic Blocking Drugs and other Antihypertensive Drugs.	Proc R Soc Med	1977	https://conductscience.org/library/papers/20919347	PubMed
20,791,420	Bethanidine, Guanethidine, and Methyldopa in Treatment of Hypertension: a Within-patient Comparison.	Br Med J	1968	https://conductscience.org/library/papers/20791420	PubMed
20,791,413	Drugs in control of hypertension.	Br Med J	1968	https://conductscience.org/library/papers/20791413	PubMed
19,821,316	Methyldopa for primary hypertension.	Cochrane Database Syst Rev	2009	https://conductscience.org/library/papers/19821316	PubMed
18,730,059	Recent concepts in the clinical pharmacology of anithypertensive drugs.	Calif Med	1967	https://conductscience.org/library/papers/18730059	PubMed
6,025,595	Double-blind trial of four hypotensive drugs (methyldopa and three sympatholytic agents).	Br Med J	1967	https://conductscience.org/library/papers/6025595	PubMed
5,761,914	Treatment of hypertension with propranolol.	Br Med J	1969	https://conductscience.org/library/papers/5761914	PubMed
5,381,984	[Fluorescence histochemical studies on the effect of alpha methyldopa on rat small intestine].	Klin Wochenschr	1969	https://conductscience.org/library/papers/5381984	PubMed
5,127,116	Hypertension and depression: interrelated problems in therapy.	J R Coll Physicians Lond	1971	https://conductscience.org/library/papers/5127116	PubMed

1 to 10 of 17

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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