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Paper · 53834

Purification of RNA-instructed DNA polymerase from human leukemic spleens.

Witkin SS and 2 others. Proc Natl Acad Sci U S A, 1975. Cited by 59 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Purification of RNA-instructed DNA polymerase from human leukemic spleens. Papers, record 53834. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/53834

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Purification of RNA-instructed DNA polymerase from human leukemic spleens.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1975
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
59
iCite
Relative citation ratio, by iCite
1.94
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Witkin SSS S
2Ohno TT
3Spiegelman SS

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Leukemia, LymphoidMajor topic
RNA-Directed DNA PolymeraseMajor topic
SpleenMajor topic
Enzyme Activation
Humans
Magnesium
Nucleic Acid Hybridization
RNA, Viral
Rauscher Virus

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,097,496Characteristics of cores of avian leuko-sarcoma viruses.Virology1970https://conductscience.org/library/papers/4097496PubMed
24,108,031Characteristics of the structural components of the mouse mammary tumor virus. I. Morphological and biochemical studies.Virology1971https://conductscience.org/library/papers/4108031PubMed
34,112,071Surface-active agents for isolation of the core component of avian myeloblastosis virus.J Virol1972https://conductscience.org/library/papers/4112071PubMed
44,117,770Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4117770PubMed
54,117,890Reverse transcriptase activity of human acute leukaemic cells: purification of the enzyme, response to AMV 70S RNA, and characterization of the DNA product.Nat New Biol1972https://conductscience.org/library/papers/4117890PubMed
64,117,891Human leukaemic cells contain reverse transcriptase associated with a high molecular weight virus-related RNA.Nat New Biol1972https://conductscience.org/library/papers/4117891PubMed
74,123,690Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4123690PubMed
84,124,682Further evidence for oncornaviruses in human milk: the production of cores.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4124682PubMed
94,126,727Particles with RNA of high molecular weight and RNA-directed DNA polymerase in human brain tumors.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4126727PubMed
104,137,655Evidence of particle-associated RNA-directed DNA polymerase and high molecular weight RNA in human gastrointestinal and lung malignancies.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4137655PubMed

1 to 10 of 21

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Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 59 citations.

PMIDTitleJournalYearIn PapersSource
38,399,945Selected Milestones in Antiviral Drug Development.Viruses2024https://conductscience.org/library/papers/38399945PubMed
6,319,800RNA-tumorviruses, oncogenes, and their possible role in human carcinogenesis.Klin Wochenschr1983https://conductscience.org/library/papers/6319800PubMed
6,196,826Immunological characterization of reverse transcriptase from human tumor tissues.Surv Immunol Res1983https://conductscience.org/library/papers/6196826PubMed
6,173,035Evidence for two forms of reverse transcriptase in human placenta of a patient with breast cancer. Purification and biochemical characterization of the enzymes.Biochem J1981https://conductscience.org/library/papers/6173035PubMed
6,159,025Human leukemia viruses? RNA tumor viruses, human malignancies, and concepts of viral carcinogenesis.Blut1980https://conductscience.org/library/papers/6159025PubMed
857,824A new cell line from a human chondrosarcoma.Br J Cancer1977https://conductscience.org/library/papers/857824PubMed
265,540Purification and characterization of the DNA polymerase of human breast cancer particles.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/265540PubMed
178,390[Leukemia viruses].Blut1976https://conductscience.org/library/papers/178390PubMed
86,545Electron microscopical and biochemical investigations on retra viruses in spleen tissue in malignancy.J Cancer Res Clin Oncol1979https://conductscience.org/library/papers/86545PubMed
82,498Inhibition of viral reverse transcriptase and human sperm DNA polymerase by anti-sperm antibodies.Clin Exp Immunol1978https://conductscience.org/library/papers/82498PubMed

1 to 10 of 14

See all 14 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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