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Paper53843

Carcinoembryonic antigen: evidence for multiple antigenic determinants and isoantigens.

Vrba R and 2 others. Proc Natl Acad Sci U S A, 1975. Cited by 62 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Carcinoembryonic antigen: evidence for multiple antigenic determinants and isoantigens. Papers, record 53843. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/53843

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Carcinoembryonic antigen: evidence for multiple antigenic determinants and isoantigens.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1975
PubMed
Publication types
Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
62
iCite
Relative citation ratio, by iCite
2.63
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Vrba RR
2Alpert EE
3Isselbacher KJK J

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carcinoembryonic AntigenMajor topic
EpitopesMajor topic
IsoantigensMajor topic
Carcinoma
Colonic Neoplasms
Humans
Liver Neoplasms
Male
Neoplasm Metastasis

Source PubMed

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,140,871Isolation and characterization of a homogeneous isomeric species of carcinoembryonic antigen: cea-s.Int J Cancer1975https://conductscience.org/library/papers/1140871PubMed
21,172,874Carcinoembryonic antigen.JAMA1975https://conductscience.org/library/papers/1172874PubMed
314,270,243DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.J Exp Med1965https://conductscience.org/library/papers/14270243PubMed
4163,645Structural studies on carcinoembryonic antigen. Periodate oxidation.Biochemistry1975https://conductscience.org/library/papers/163645PubMed
5166,311Association of an isomeric species of carcinoembryonic antigen with neoplasia of the gastrointestinal tract.N Engl J Med1975https://conductscience.org/library/papers/166311PubMed
64,115,954Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4115954PubMed
74,202,377Heterogeneity of the carcinoembryonic antigen.Immunochemistry1973https://conductscience.org/library/papers/4202377PubMed
84,366,939Proceedings: Heterogeneity of carcinoembryonic antigen.Cancer Res1974https://conductscience.org/library/papers/4366939PubMed
94,463,160Studies on the structure of the carcinoembryonic antigen. I. some deductions on the basis of chemical degradations.Immunochemistry1974https://conductscience.org/library/papers/4463160PubMed
104,624,559Isolation and characterization of carcinoembryonic antigen.Immunochemistry1972https://conductscience.org/library/papers/4624559PubMed
114,663,603A clinical comparison of two radioimmunoassays for carcinoembryonic antigen (CEA).Immunol Commun1972https://conductscience.org/library/papers/4663603PubMed
124,726,659Carcinoembryonic antigen (CEA): separation of CEA-reacting molecules from tumor, fetal gut, meconium and normal colon.Immunol Commun1973https://conductscience.org/library/papers/4726659PubMed
134,811,605Carcinoembryonic antigen (CEA) assay. A laboratory adjunct in the diagnosis and management of cancer.Hum Pathol1974https://conductscience.org/library/papers/4811605PubMed
144,817,573Preparation and isolation of immunologically active glycopeptides from carcinoembryonic antigen (CEA).Int J Cancer1974https://conductscience.org/library/papers/4817573PubMed
1548,256Nature of the tumor-associated determinant(s) of carcinoembryonic antigen.Proc Natl Acad Sci U S A1975https://conductscience.org/library/papers/48256PubMed
165,064,897The preparation of purified carcinoembryonic antigen of the human digestive system from large quantities of tumor tissue.Immunochemistry1972https://conductscience.org/library/papers/5064897PubMed
175,262,998The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.Proc Natl Acad Sci U S A1969https://conductscience.org/library/papers/5262998PubMed
185,435,499Molecular weights and metabolism of rat brain proteins.Biochem J1970https://conductscience.org/library/papers/5435499PubMed

Cited by5

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 62 citations.

PMIDTitleJournalYearIn PapersSource
41,273,124Novel insights into predicting the presence of micropapillary and solid components in stage IA lung adenocarcinoma using machine learning models of modifiable risk factors.Ann Med2025https://conductscience.org/library/papers/41273124PubMed
7,284,234Application of monoclonal antibodies to purified CEA in clinical radioimmunoassay of human serum.Br J Cancer1981https://conductscience.org/library/papers/7284234PubMed
6,357,957Carcinoembryonic antigen in retinoblastoma. An immunohistochemical study.Graefes Arch Clin Exp Ophthalmol1983https://conductscience.org/library/papers/6357957PubMed
323,284Results of a nationwide proficiency test for carcinoembryonic antigen.J Clin Microbiol1977https://conductscience.org/library/papers/323284PubMed
89,043Fractionation of mouse alpha-fetoprotein.Experientia1979https://conductscience.org/library/papers/89043PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
CEACAM31,084PubTator's text mininghttps://conductscience.org/library/genes/1084

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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