Paper · 57443

Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance.

Bryant MG and 5 others. Lancet, 1976. Cited by 518 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Papers, record 57443. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/57443

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance.; PubMed
Journal: Lancet; PubMed
Year: 1976; PubMed
Publication types: Comparative Study, Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/57443/; PubMed
DOI: https://doi.org/10.1016/s0140-6736(76)91863-8; PubMed
The journal: https://conductscience.org/library/journal-index/2985213R; PubMed
Citations, by iCite: 518; iCite
Relative citation ratio, by iCite: 20.8; iCite
Revised in PubMed: 2019-06-10; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Bryant MG	M G
2	Polak MM	M M
3	Modlin I	I
4	Bloom SR	S R
5	Albuquerque RH	R H
6	Pearse AG	A G

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gastrointestinal Hormones	Major topic
Neurotransmitter Agents	Major topic
Peptides	Major topic
Adrenal Glands
Animals
Biliary Tract
Brain Chemistry
Chromatography, Gel
Fluorescent Antibody Technique
Humans
Mice
Nerve Fibers, Myelinated
Pancreas
Pituitary Gland
Radioimmunoassay
Rats
Salivary Glands
Swine
Urinary Bladder

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by110

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 518 citations.

PMID	Title	Journal	Year	In Papers	Source
41,641,032	Neuropeptidergic systems in psychiatric disorders.	Front Endocrinol (Lausanne)	2025	https://conductscience.org/library/papers/41641032	PubMed
35,409,109	A Focus on Enterochromaffin Cells among the Enteroendocrine Cells: Localization, Morphology, and Role.	Int J Mol Sci	2022	https://conductscience.org/library/papers/35409109	PubMed
32,357,625	Detection of vasoactive intestinal polypeptide messenger RNA in ganglioneuroblastoma by in situ hybridization.	Endocr Pathol	1990	https://conductscience.org/library/papers/32357625	PubMed
31,949,463	Zhujie Hewei Granules Ameliorated Reflux Esophagitis in Rats.	Evid Based Complement Alternat Med	2019	https://conductscience.org/library/papers/31949463	PubMed
31,429,729	Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens.	BMC Ophthalmol	2019	https://conductscience.org/library/papers/31429729	PubMed
28,385,693	Expression and localization of VPAC1, the major receptor of vasoactive intestinal peptide along the length of the intestine.	Am J Physiol Gastrointest Liver Physiol	2017	https://conductscience.org/library/papers/28385693	PubMed
23,339,175	Functional role of vasoactive intestinal polypeptide in inhibitory motor innervation in the mouse internal anal sphincter.	J Physiol	2013	https://conductscience.org/library/papers/23339175	PubMed
22,825,651	Expression of VIP and its receptors in the testis of the spotted ray Torpedo marmorata (Risso 1880).	J Mol Neurosci	2012	https://conductscience.org/library/papers/22825651	PubMed
22,207,455	Vasoactive intestinal peptide enhances TNF-α-induced IL-6 and IL-8 synthesis in human proximal renal tubular epithelial cells by NF-κB-dependent mechanism.	Inflammation	2012	https://conductscience.org/library/papers/22207455	PubMed
16,592,433	Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons.	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/16592433	PubMed

1 to 10 of 110

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
VIP	7,432	PubTator's text mining	https://conductscience.org/library/genes/7432

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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