Paper · 589505

The caffeine test of isolated human muscle in relation to malignant hyperthermia.

Kalow W and 2 others. Can Anaesth Soc J, 1977. Cited by 101 papers, by iCite.

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ConductScience Library. The caffeine test of isolated human muscle in relation to malignant hyperthermia. Papers, record 589505. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/589505

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The caffeine test of isolated human muscle in relation to malignant hyperthermia.; PubMed
Journal: Can Anaesth Soc J; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/589505/; PubMed
DOI: https://doi.org/10.1007/bf03006711; PubMed
The journal: https://conductscience.org/library/journal-index/0371163; PubMed
Citations, by iCite: 101; iCite
Relative citation ratio, by iCite: 5.23; iCite
Revised in PubMed: 2019-09-02; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kalow W	W
2	Britt BA	B A
3	Richter A	A

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Caffeine	Major topic
Malignant Hyperthermia	Major topic
Muscle Contraction	Major topic
Adolescent
Adult
Child
Child, Preschool
Female
Humans
In Vitro Techniques
Male
Middle Aged
Succinylcholine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	5,773,497	Hereditary aspects of malignant hyperthermia.	Can Anaesth Soc J	1969	https://conductscience.org/library/papers/5773497	PubMed
2	5,569,139	Malignant hyperpyrexia: a study of a family. Case report.	Br J Anaesth	1971	https://conductscience.org/library/papers/5569139	PubMed
3	5,547,253	Effect of denervating skeletal muscle on calcium binding by isolated sarcolemma.	Exp Neurol	1971	https://conductscience.org/library/papers/5547253	PubMed
4	5,038,373	Succinylcholine and malignant hyperthermia.	Fed Proc	1972	https://conductscience.org/library/papers/5038373	PubMed
5	4,411,635	A fatal case of malignant hyperthermia during anaesthesia and a study of the patient's blood relatives.	Ann Chir Gynaecol Fenn	1974	https://conductscience.org/library/papers/4411635	PubMed
6	4,672,179	Abnormal creatine-phosphokinase isoenzyme pattern in families with malignant hyperpyrexia.	Anesth Analg	1972	https://conductscience.org/library/papers/4672179	PubMed
7	4,274,465	Editorial: Malignant hyperthermia: a pharmacogenetic disease of skeletal and cardiac muscle.	N Engl J Med	1974	https://conductscience.org/library/papers/4274465	PubMed
8	5,077,443	Screening for malignant hyperpyrexia.	Br Med J	1972	https://conductscience.org/library/papers/5077443	PubMed
9	4,097,281	Metabolic error of muscle metabolism after recovery from malignant hyperthermia.	Lancet	1970	https://conductscience.org/library/papers/4097281	PubMed
10	5,155,404	Malignant hyperthermia during anaesthesia. A neurophysiological and neuropathological follow-up study of a patient and his family.	Acta Anaesthesiol Scand	1971	https://conductscience.org/library/papers/5155404	PubMed

1 to 10 of 32

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 101 citations.

PMID	Title	Journal	Year	In Papers	Source
35,068,214	In vitro contractile studies within isolated tissue baths: Translational research from Visible Heart® Laboratories.	Exp Biol Med (Maywood)	2022	https://conductscience.org/library/papers/35068214	PubMed
32,632,746	Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture.	Sports Med	2020	https://conductscience.org/library/papers/32632746	PubMed
32,034,582	Caffeine as a tool to investigate sarcoplasmic reticulum and intracellular calcium dynamics in human skeletal muscles.	J Muscle Res Cell Motil	2021	https://conductscience.org/library/papers/32034582	PubMed
28,430,550	Round Table on Malignant Hyperthermia in Physically Active Populations: Meeting Proceedings.	J Athl Train	2017	https://conductscience.org/library/papers/28430550	PubMed
15,236,048	Effects of anesthetic and related agents on calcium-induced calcium release from sarcoplasmic reticulum isolated from rabbit skeletal muscle.	J Anesth	1989	https://conductscience.org/library/papers/15236048	PubMed
7,751,854	Ryanodine receptor gene point mutation and malignant hyperthermia susceptibility.	J Neurol	1995	https://conductscience.org/library/papers/7751854	PubMed
7,378,869	Is bacterial contamination of anaesthetic equipment adequately controlled by pasteurization alone?	Can Anaesth Soc J	1980	https://conductscience.org/library/papers/7378869	PubMed
7,353,185	Comparison of effects of several inhalation anaesthetics on caffeine-induced contractures of normal and malignant hyperthermic skeletal muscle.	Can Anaesth Soc J	1980	https://conductscience.org/library/papers/7353185	PubMed
7,353,184	Effect of temperature, time and fascicle size on the caffeine contracture test.	Can Anaesth Soc J	1980	https://conductscience.org/library/papers/7353184	PubMed
7,139,491	A family with intussusception and malignant hyperthermia.	Can Med Assoc J	1982	https://conductscience.org/library/papers/7139491	PubMed

1 to 10 of 22

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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