Paper · 598403

Effects of the beta-adrenoceptor antagonists acebutolol and metoprolol on sleep pattern in normal subjects.

Kayed K and 1 other. Eur J Clin Pharmacol, 1977. Cited by 16 papers, by iCite.

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ConductScience Library. Effects of the beta-adrenoceptor antagonists acebutolol and metoprolol on sleep pattern in normal subjects. Papers, record 598403. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/598403

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Effects of the beta-adrenoceptor antagonists acebutolol and metoprolol on sleep pattern in normal subjects.; PubMed
Journal: Eur J Clin Pharmacol; PubMed
Year: 1977; PubMed
Publication types: Clinical Trial, Controlled Clinical Trial, Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/598403/; PubMed
DOI: https://doi.org/10.1007/bf00562445; PubMed
The journal: https://conductscience.org/library/journal-index/1256165; PubMed
Citations, by iCite: 16; iCite
Relative citation ratio, by iCite: 0.98; iCite
Revised in PubMed: 2019-08-13; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Kayed K	K
2	Godtlibsen OB	O B

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Acebutolol	Major topic
Metoprolol	Major topic
Propanolamines	Major topic
Sleep	Major topic
Adult
Electroencephalography
Female
Humans
Male
Mental Recall
Placebos
Task Performance and Analysis
Time Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References15

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,404,445	On the psychopharmacology of beta adrenergic blockade.	Curr Ther Res Clin Exp	1972	https://conductscience.org/library/papers/4404445	PubMed
2	4,397,033	Sedative effects of alpha-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs.	Eur J Pharmacol	1971	https://conductscience.org/library/papers/4397033	PubMed
3	5,072,238	Central and peripheral effects of propranolol and sotalol in normal human subjects.	Br J Pharmacol	1972	https://conductscience.org/library/papers/5072238	PubMed
4	4,321,919	The influence of adrenergic and cholinergic blocking drugs on the glycogen content of the brain in rats deprived of paradoxical sleep.	J Neurochem	1970	https://conductscience.org/library/papers/4321919	PubMed
5	4,963,062	The role of the beta-adrenergic system in behavior: antidepressant effects of propranolol.	Curr Ther Res Clin Exp	1967	https://conductscience.org/library/papers/4963062	PubMed
6	192,560	Controlled clinical investigation of trimeprazine as a sleep-inducer in normal subjects.	Eur J Clin Pharmacol	1977	https://conductscience.org/library/papers/192560	PubMed
7	5,471,904	Verbal anxiety and the beta adrenergic receptors: a facilitating mechanism?	J Nerv Ment Dis	1970	https://conductscience.org/library/papers/5471904	PubMed
8	598,404	Central effects of the beta-adrenergic blocking agent acebutolol. A quantitative EEG study using normalised slope descriptors.	Eur J Clin Pharmacol	1977	https://conductscience.org/library/papers/598404	PubMed
9	4,397,229	The short-term effects of adrenergic-blocking agents in a small group of psychotic patients. Preliminary clinical observations.	Psychiatr Neurol Neurochir	1970	https://conductscience.org/library/papers/4397229	PubMed
10	4,402,372	Possible mechanism (s) of alprenolol (beta adrenergic receptor blocking agent) prolongation of pentobarbital hypnosis in mice.	J Pharmacol Exp Ther	1972	https://conductscience.org/library/papers/4402372	PubMed

1 to 10 of 15

See all 15 references

Cited by2

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 16 citations.

PMID	Title	Journal	Year	In Papers	Source
27,847,879	Targeting modulation of noradrenalin release in the brain for amelioration of REMS loss-associated effects.	J Transl Int Med	2015	https://conductscience.org/library/papers/27847879	PubMed
20,175,288	Possible indications of beta-blockers in the perioperative period other than prevention of cardiac ischemia.	J Anesth	2010	https://conductscience.org/library/papers/20175288	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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