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Paper6284136

Desensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein.

Dix CJ and 2 others. Biochem J, 1982. Cited by 45 papers, by iCite.

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ConductScience Library. Desensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein. Papers, record 6284136. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6284136

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Desensitization of tumour Leydig cells by lutropin: evidence for uncoupling of the lutropin receptor from the guanine nucleotide-binding protein.
PubMed
Journal
Biochem J
PubMed
Year
1982
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
45
iCite
Relative citation ratio, by iCite
1.27
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Dix CJC J
2Schumacher MM
3Cooke BAB A

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Leydig Cell TumorMajor topic
Luteinizing HormoneMajor topic
Receptors, Cell SurfaceMajor topic
Adenylyl Cyclases
Animals
Bucladesine
Cell Membrane
Cholera Toxin
Cyclic AMP
GTP-Binding Proteins
In Vitro Techniques
Rats
Receptors, LH

Source PubMed

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,334,491Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides.J Biol Chem1972https://conductscience.org/library/papers/4334491PubMed
2177,461Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.J Cyclic Nucleotide Res1975https://conductscience.org/library/papers/177461PubMed
3939,193Adenylyl cyclase activities in ovarian tissues. II. Regulation of responsiveness to LH, FSH, and PGE1 in the rabbit.Endocrinology1976https://conductscience.org/library/papers/939193PubMed
4189,752Correlation of protein kinase activation and testosterone production after stimulation of Leydig cells with luteinizing hormone.Biochem J1976https://conductscience.org/library/papers/189752PubMed
5191,816Gonadotropin-induced regulation of luteinizing hormone receptors and desensitization of testicular 3':5'-cyclic AMP and testosterone responses.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/191816PubMed
6852,594Intracellular uptake and catabolism of lutropin by testicular tissue in vivo.FEBS Lett1977https://conductscience.org/library/papers/852594PubMed
7192,612HCG-dependent regulation of gonadotropin receptor sites: negative control in testicular Leydig cells.Mol Cell Endocrinol1977https://conductscience.org/library/papers/192612PubMed
8193,500Relationship between testosterone, fluid content and luteinizing hormone receptors in the rat testis.Biochem Biophys Res Commun1977https://conductscience.org/library/papers/193500PubMed
9195,852hCG suppression of LH receptors and responsiveness of testicular tissue to hCG.Mol Cell Endocrinol1977https://conductscience.org/library/papers/195852PubMed
10195,986Mechanism of hormonally induced refractoriness of ovarian adenylate cyclase to luteinizing hormone and prostaglandin E.J Cyclic Nucleotide Res1977https://conductscience.org/library/papers/195986PubMed
11335,847Mechanism of action of cholera toxin.Adv Cyclic Nucleotide Res1977https://conductscience.org/library/papers/335847PubMed
12200,625Hormonal regulation of testicular luteinizing hormone receptors. Effects on cyclic AMP and testosterone responses in isolated Leydig cells.J Biol Chem1977https://conductscience.org/library/papers/200625PubMed
13208,069Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/208069PubMed
14208,527Early hCG-induced desensitization in Leydig cells.Biochem Biophys Res Commun1978https://conductscience.org/library/papers/208527PubMed
15209,335Internalisation of gonadotrophin--receptor complex in ovarian luteal cells.Nature1978https://conductscience.org/library/papers/209335PubMed
1698,070A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.Anal Biochem1978https://conductscience.org/library/papers/98070PubMed
17217,174Gonadotropin receptors and regulation of steroidogenesis in the testis and ovary.Vitam Horm1978https://conductscience.org/library/papers/217174PubMed
1887,155Leydig cell desensitization by increased cyclic-AMP inactivation.Arch Androl1979https://conductscience.org/library/papers/87155PubMed
19221,044A Leydig cell tumour: a model for the study of lutropin action.Biochim Biophys Acta1979https://conductscience.org/library/papers/221044PubMed
20221,192Resensitization of the desensitized follicular adenylyl cyclase system to luteinizing hormone.Endocrinology1979https://conductscience.org/library/papers/221192PubMed

See all 28 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 45 citations.

PMIDTitleJournalYearIn PapersSource
23,990,106Luteinizing hormone receptors are confined in mesoscale plasma membrane microdomains throughout recovery from receptor desensitization.Cell Biochem Biophys2014https://conductscience.org/library/papers/23990106PubMed
7,115,353Resensitization of lutropin-desensitized tumour Leydig-cell adenylate cyclase with human erythrocyte membranes.Biochem J1982https://conductscience.org/library/papers/7115353PubMed
6,508,730Cell-free lutropin-dependent desensitization of the lutropin-sensitive adenylate cyclase of pig ovarian follicles is dependent on ATP.Biochem J1984https://conductscience.org/library/papers/6508730PubMed
6,430,271Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis.Biochem J1984https://conductscience.org/library/papers/6430271PubMed
6,087,796Characterization of the homologous and heterologous desensitization of rat Leydig-tumour-cell adenylate cyclase.Biochem J1984https://conductscience.org/library/papers/6087796PubMed
3,140,790The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate.Biochem J1988https://conductscience.org/library/papers/3140790PubMed
3,006,667Evidence for the rapid internalization and recycling of lutropin receptors in rat testis Leydig cells.Biochem J1986https://conductscience.org/library/papers/3006667PubMed
2,998,334Control and production of leukotriene B4 in rat tumour and testicular Leydig cells.Biochem J1985https://conductscience.org/library/papers/2998334PubMed
2,996,491Adenosine potentiates lutropin-stimulated cyclic AMP production and inhibits lutropin-induced desensitization of adenylate cyclase in rat Leydig tumour cells.Biochem J1985https://conductscience.org/library/papers/2996491PubMed
2,820,376Similarities and differences in phorbol ester- and luteinizing-hormone-induced desensitization of rat tumour Leydig-cell adenylate cyclase.Biochem J1987https://conductscience.org/library/papers/2820376PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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