ConductScience.org, home
Papers
API referenceFor AI assistants

Paper6358043

Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin 1) or endotoxin.

Sobrado J and 4 others. Infect Immun, 1983. Cited by 104 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin 1) or endotoxin. Papers, record 6358043. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6358043

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin 1) or endotoxin.
PubMed
Journal
Infect Immun
PubMed
Year
1983
PubMed
Publication types
Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
104
iCite
Relative citation ratio, by iCite
4.48
iCite
Revised in PubMed
2021-05-26
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sobrado JJ
2Moldawer LLL L
3Bistrian BRB R
4Dinarello CAC A
5Blackburn GLG L

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
EndotoxinsMajor topic
FeverMajor topic
IbuprofenMajor topic
Interleukin-1Major topic
LeukocytesMajor topic
PyrogensMajor topic
Animals
Drug Evaluation, Preclinical
Guinea Pigs
Humans
Male
Salmonella enteritidis
Time Factors

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AI-15614NIAID NIH HHSUnited StatesR01AI015614PubMed and NIHNIH RePORTER
AM-31933NIADDK NIH HHSUnited StatesR01AM031933PubMed and NIHNIH RePORTER
R37AI015614NIHNIH RePORTER

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,766,528In vivo demonstration of nitrogen-sparing mechanisms for glucose and amino acids in the injured rat.Metabolism1980https://conductscience.org/library/papers/6766528PubMed
2314,491Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen.J Exp Med1979https://conductscience.org/library/papers/314491PubMed
36,965,699The activity of partially purified leukocytic endogenous mediator in endotoxin-resistant C3H/HeJ mice.J Lab Clin Med1980https://conductscience.org/library/papers/6965699PubMed
47,394,709Effects of major skeletal trauma on whole body protein turnover in man measured by L-[1,14C]-leucine.Surgery1980https://conductscience.org/library/papers/7394709PubMed
57,411,449Prostaglandin E levels in third ventricular cerebrospinal fluid of rabbits during fever and changes in body temperature.J Physiol1980https://conductscience.org/library/papers/7411449PubMed
67,411,537Neutrophil release after injections of endotoxin or leukocytic endogenous mediator into rats.J Reticuloendothel Soc1980https://conductscience.org/library/papers/7411537PubMed
77,462,686Effect of indomethacin on increased resistance to bacterial infection and on febrile responses induced by muramyl dipeptide.J Infect Dis1980https://conductscience.org/library/papers/7462686PubMed
86,803,569Hypothesis: leukocyte endogenous mediator/endogenous pyrogen/lymphocyte-activating factor modulates the development of nonspecific and specific immunity and affects nutritional status.Am J Clin Nutr1982https://conductscience.org/library/papers/6803569PubMed
97,043,704The significance of iron in infection.Rev Infect Dis1981https://conductscience.org/library/papers/7043704PubMed
106,805,324Molecular basis of fever in humans.Am J Med1982https://conductscience.org/library/papers/6805324PubMed
117,085,045Studies on the active site of human leukocytic pyrogen.Inflammation1982https://conductscience.org/library/papers/7085045PubMed
127,107,893Ibuprofen in canine endotoxin shock.J Clin Invest1982https://conductscience.org/library/papers/7107893PubMed
136,822,064Alterations in tyrosine and protein kinetics produced by injury and branched chain amino acid administration in rats.Clin Sci (Lond)1983https://conductscience.org/library/papers/6822064PubMed
146,402,699Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever.N Engl J Med1983https://conductscience.org/library/papers/6402699PubMed
156,338,570Zinc and infection.Rev Infect Dis1983https://conductscience.org/library/papers/6338570PubMed
166,338,745Relationship of trace metals to fever during infection: are prostaglandins involved?Am J Physiol1983https://conductscience.org/library/papers/6338745PubMed
176,865,755Leukocyte endogenous mediator alters protein dynamics in rats.Metabolism1983https://conductscience.org/library/papers/6865755PubMed
186,410,241Muscle proteolysis in sepsis or trauma.N Engl J Med1983https://conductscience.org/library/papers/6410241PubMed
195,911,031Induction of plasma protein synthesis in response to trauma.Am J Physiol1966https://conductscience.org/library/papers/5911031PubMed
205,635,765Metabolic balance studies during induced hyperthermia in man.J Appl Physiol1968https://conductscience.org/library/papers/5635765PubMed

See all 31 references

Cited by23

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 104 citations.

PMIDTitleJournalYearIn PapersSource
26,360,486Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response.J Perinat Med2016https://conductscience.org/library/papers/26360486PubMed
26,352,068Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile.J Perinat Med2016https://conductscience.org/library/papers/26352068PubMed
24,940,599Plasma metabolomic profiling to reveal antipyretic mechanism of Shuang-huang-lian injection on yeast-induced pyrexia rats.PLoS One2014https://conductscience.org/library/papers/24940599PubMed
23,465,415Effects of Bai-Hu decoction on fever induced by lipopolysaccharide.Kaohsiung J Med Sci2013https://conductscience.org/library/papers/23465415PubMed
16,992,968Separate mechanisms inside and outside the blood-brain barrier inducing metabolic changes in febrile rabbits.J Physiol1987https://conductscience.org/library/papers/16992968PubMed
8,239,784Acute response of human muscle protein to catabolic hormones.Ann Surg1993https://conductscience.org/library/papers/8239784PubMed
6,396,576Differential acute-phase responses in febrile and cold- and heat-exposed rabbits.Pflugers Arch1984https://conductscience.org/library/papers/6396576PubMed
6,380,557Effect of bacterial endotoxin on body temperature, plasma zinc and plasma concentrations of the acute-phase protein serum amyloid p component in mice.Br J Exp Pathol1984https://conductscience.org/library/papers/6380557PubMed
3,880,718Effect of age on fever and acute-phase response of rats to endotoxin and Salmonella typhimurium.Infect Immun1985https://conductscience.org/library/papers/3880718PubMed
3,543,052Secretory products of macrophages.J Clin Invest1987https://conductscience.org/library/papers/3543052PubMed
3,527,391Time course changes in blood metabolites during endotoxin fever in sheep.Can J Vet Res1986https://conductscience.org/library/papers/3527391PubMed
3,527,153The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats.Biochem J1986https://conductscience.org/library/papers/3527153PubMed
3,284,911Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines.J Clin Invest1988https://conductscience.org/library/papers/3284911PubMed
3,137,331Is the central arachidonic acid cascade system involved in the development of acute-phase response in rabbits?J Physiol1988https://conductscience.org/library/papers/3137331PubMed
3,115,552Hepatic serine and alanine metabolism during endotoxin-induced fever in sheep.Can J Vet Res1987https://conductscience.org/library/papers/3115552PubMed
3,090,790Fever: is it beneficial?Yale J Biol Med1986https://conductscience.org/library/papers/3090790PubMed
2,785,120Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1.J Clin Invest1989https://conductscience.org/library/papers/2785120PubMed
2,659,688Interleukin-1 and the response to injury.Immunol Res1989https://conductscience.org/library/papers/2659688PubMed
2,514,261Brain regions involved in the development of acute phase responses accompanying fever in rabbits.J Physiol1989https://conductscience.org/library/papers/2514261PubMed
2,475,610Effects of urethane, ambient temperature and injection route on rat body temperature and metabolism due to endotoxins.J Physiol1988https://conductscience.org/library/papers/2475610PubMed

See all 23 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/6358043

GET https://conductscience.org/api/papers/v1/6358043/references?page=2

API referenceFor AI assistants