Paper · 6452013
The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity.
Mahler RJ. Acta Diabetol Lat, 1981. Cited by 13 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity. Papers, record 6452013. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6452013
On this page
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity.
- PubMed
Topics18
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Insulin Resistance | Major topic |
| Islets of Langerhans | Major topic |
| Obesity | Major topic |
| Adipose Tissue | |
| Alloxan | |
| Animals | |
| Glucagon | |
| Glucose | |
| Humans | |
| Hyperplasia | |
| Insulin | |
| Liver | |
| Mice | |
| Mice, Obese | |
| Microscopy, Electron | |
| Muscles | |
| Receptor, Insulin | |
| Streptozocin |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References67
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 993,336 | Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. | J Clin Invest | 1976 | https://conductscience.org/library/papers/993336 | PubMed |
| 2 | 5,278,387 | Insulin resistance in genetically obese, hyperglycemic mice. | Endocrinology | 1971 | https://conductscience.org/library/papers/5278387 | PubMed |
| 3 | 723,646 | Studies of insulin insensitivity in soleus muscles of obese mice. | Metabolism | 1978 | https://conductscience.org/library/papers/723646 | PubMed |
| 4 | 873,075 | Insulin binding in diabetes. Relationships with plasma insulin levels and insulin sensitivity. | Diabetes | 1977 | https://conductscience.org/library/papers/873075 | PubMed |
| 5 | 193,098 | Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action. | Proc Natl Acad Sci U S A | 1977 | https://conductscience.org/library/papers/193098 | PubMed |
| 6 | 4,266,834 | A combined biochemical and histological study on the islets of Langerhans in the genetically obese hyperglycaemic mouse and the lean mouse, including observations on the effects of streptozotocin treatment. | J Endocrinol | 1973 | https://conductscience.org/library/papers/4266834 | PubMed |
| 7 | 892,237 | Immunoreactive glucagon levels in obese-hyperglycemic (ob/ob) mice. | Diabetes | 1977 | https://conductscience.org/library/papers/892237 | PubMed |
| 8 | 5,970,123 | Insulin resistance of the inherently obese mouse--obob. | Nature | 1966 | https://conductscience.org/library/papers/5970123 | PubMed |
| 9 | 5,162,297 | Genetically transmitted obesity in rodents. | Physiol Rev | 1971 | https://conductscience.org/library/papers/5162297 | PubMed |
| 10 | 4,935,445 | The effect of experimental insulin deficiency on glucagon secretion. | J Clin Invest | 1971 | https://conductscience.org/library/papers/4935445 | PubMed |
1 to 10 of 67
See all 67 referencesCited by6
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 13 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 39,012,663 | Aging and "Age-Related" Diseases - What Is the Relation? | Aging Dis | 2024 | https://conductscience.org/library/papers/39012663 | PubMed |
| 35,777,366 | (-)-Epicatechin Reverses Glucose Intolerance in Rats Housed at Thermoneutrality. | Planta Med | 2022 | https://conductscience.org/library/papers/35777366 | PubMed |
| 33,281,458 | Development of Obesity: The Driver and the Passenger. | Diabetes Metab Syndr Obes | 2020 | https://conductscience.org/library/papers/33281458 | PubMed |
| 31,695,465 | How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases. | Diabetes Metab Syndr Obes | 2019 | https://conductscience.org/library/papers/31695465 | PubMed |
| 21,081,706 | Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice. | Am J Physiol Endocrinol Metab | 2011 | https://conductscience.org/library/papers/21081706 | PubMed |
| 17,004,039 | The role of exogenous insulin in the complex of hepatic lipidosis and ketosis associated with insulin resistance phenomenon in postpartum dairy cattle. | Vet Res Commun | 2006 | https://conductscience.org/library/papers/17004039 | PubMed |
Genes0
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
None in this release.
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this paper from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/papers/v1/6452013
GET https://conductscience.org/api/papers/v1/6452013/references?page=2