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Paper67176

The release of an endogenous pyrogen from guinea pig leukocytes in vitro: a new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity.

Chao P and 2 others. J Exp Med, 1977. Cited by 41 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The release of an endogenous pyrogen from guinea pig leukocytes in vitro: a new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity. Papers, record 67176. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/67176

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The release of an endogenous pyrogen from guinea pig leukocytes in vitro: a new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
41
iCite
Relative citation ratio, by iCite
1.49
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chao PP
2Francis LL
3Atkins EE

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
FeverMajor topic
Hypersensitivity, DelayedMajor topic
LymphocytesMajor topic
PyrogensMajor topic
Animals
Antigens
Ascitic Fluid
Cells, Cultured
Guinea Pigs
Immunization
In Vitro Techniques
Lymph Nodes
Lymphokines
Models, Biological
gamma-Globulins

Source PubMed

References15

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,343,431Species specificity of leukocytic pyrogens.J Exp Med1969https://conductscience.org/library/papers/5343431PubMed
255,309On soluble mediators of immunologic regulation.Cell Immunol1976https://conductscience.org/library/papers/55309PubMed
35,904,554The association of fever and antibody response in rabbits immunized with human serum albumin.J Clin Invest1966https://conductscience.org/library/papers/5904554PubMed
45,935,620Human leukocyte pyrogen producing fever in rabbits.Proc Soc Exp Biol Med1966https://conductscience.org/library/papers/5935620PubMed
613,708,532The passive transfer of sensitivity to antigen-induced fever.J Clin Invest1961https://conductscience.org/library/papers/13708532PubMed
713,779,030Delayed hypersensitivity. V. The effect of x-irradiation on the development of delayed hypersensitivity and antibody formation.J Exp Med1960https://conductscience.org/library/papers/13779030PubMed
814,157,026STUDIES ON THE PATHOGENESIS OF FEVER. 13. THE EFFECT OF PHAGOCYTOSIS ON THE RELEASE OF ENDOGENOUS PYROGEN BY POLYMORPHONUCLEAR LEUKOCYTES.J Exp Med1964https://conductscience.org/library/papers/14157026PubMed
914,222,350STUDIES IN STAPHYLOCOCCAL FEVER. IV. HYPERSENSITIVITY TO CULTURE FILTRATES.Yale J Biol Med1964https://conductscience.org/library/papers/14222350PubMed
1014,316,942STUDIES ON TUBERCULIN FEVER. 3. MECHANISMS INVOLVED IN THE RELEASE OF ENDOGENOUS PYROGEN IN VITRO.J Exp Med1965https://conductscience.org/library/papers/14316942PubMed
114,112,261Studies on the mechanism of fever accompanying delayed hypersensitivity. The role of the sensitized lymphocyte.J Exp Med1972https://conductscience.org/library/papers/4112261PubMed
1248,483Macrophage activation by lymphocyte mediators.Fed Proc1975https://conductscience.org/library/papers/48483PubMed
134,873,023Pathogenetic mechanisms in experimental immune fever.J Exp Med1968https://conductscience.org/library/papers/4873023PubMed
144,910,480Factors affecting the quantitative production and assay of human leukocytic pyrogen.J Lab Clin Med1970https://conductscience.org/library/papers/4910480PubMed
155,112,203The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs.J Exp Med1971https://conductscience.org/library/papers/5112203PubMed
165,124,960Mediators produced by sensitized lymphocytes.Fed Proc1971https://conductscience.org/library/papers/5124960PubMed

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 41 citations.

PMIDTitleJournalYearIn PapersSource
6,771,131Macrophage stimulation and the inflammatory response to asbestos.Environ Health Perspect1980https://conductscience.org/library/papers/6771131PubMed
6,768,379Microbial and immunological investigations and remedial action after an outbreak of humidifier fever.Br J Ind Med1980https://conductscience.org/library/papers/6768379PubMed
2,994,306Studies on the production of endogenous pyrogen by rabbit monocytes: the role of calcium and cyclic nucleotides.Yale J Biol Med1985https://conductscience.org/library/papers/2994306PubMed
2,930,955Chemical characterization of an interleukin-1-inducing substance derived from human mixed leukocyte reactions: IL-1-inducing substance is not gamma interferon.Yale J Biol Med1985https://conductscience.org/library/papers/2930955PubMed
1,655,640Affinity-purified soluble Fc epsilon RII/CD23 derived from a culture supernatant of an EBV-immortalized B-cell line induced a monophasic fever in rabbits.Immunology1991https://conductscience.org/library/papers/1655640PubMed
711,334Pathogenesis of fever in delayed hypersensitivity: factors influencing release of pyrogen-inducing lymphokines.Infect Immun1978https://conductscience.org/library/papers/711334PubMed
393,598Influence of antilymphocyte and antipolymorphonuclear sera on the pyrogenic effect of scarlet fever toxin.Folia Microbiol (Praha)1979https://conductscience.org/library/papers/393598PubMed
390,356Temperature and host defense.Microbiol Rev1979https://conductscience.org/library/papers/390356PubMed
349,108Bacille Calmette-Guérin infection in the mouse. Regulation of macrophage plasminogen activator by T lymphocytes and specific antigen.J Exp Med1978https://conductscience.org/library/papers/349108PubMed
345,780Macrophage proteases and rheumatic diseases: regulation of plasminogen activator by thymus-derived lymphocytes.Agents Actions1978https://conductscience.org/library/papers/345780PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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