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Paper68439

alpha-Fetoprotein induces suppressor T cells in vitro.

Murgita RA and 3 others. Nature, 1977. Cited by 161 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. alpha-Fetoprotein induces suppressor T cells in vitro. Papers, record 68439. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/68439

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
alpha-Fetoprotein induces suppressor T cells in vitro.
PubMed
Journal
Nature
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
161
iCite
Relative citation ratio, by iCite
4.75
iCite
Revised in PubMed
2021-12-03
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Murgita RAR A
2Goidl EAE A
3Kontianen SS
4Wigzell HH

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody FormationMajor topic
Immunosuppression TherapyMajor topic
T-LymphocytesMajor topic
alpha-FetoproteinsMajor topic
Cell Division
Spleen
Time Factors

Source PubMed

Cited by25

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 161 citations.

PMIDTitleJournalYearIn PapersSource
41,854,876Computational analysis of multi-omics data reveals CXCL10+ DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma.Cell Mol Life Sci2026https://conductscience.org/library/papers/41854876PubMed
38,660,138The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma.Front Oncol2024https://conductscience.org/library/papers/38660138PubMed
38,619,448Alpha-fetoprotein: Past, present, and future.Hepatol Commun2024https://conductscience.org/library/papers/38619448PubMed
33,009,373AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway.Cell Death Dis2020https://conductscience.org/library/papers/33009373PubMed
21,592,114α-Fetoprotein impairs activation of natural killer cells by inhibiting the function of dendritic cells.Clin Exp Immunol2011https://conductscience.org/library/papers/21592114PubMed
19,506,976Long-term outcomes and prognostic factors of elderly patients with hepatocellular carcinoma undergoing hepatectomy.J Gastrointest Surg2009https://conductscience.org/library/papers/19506976PubMed
14,994,148Resection of peritoneal implantation of hepatocellular carcinoma after hepatic resection: risk factors and prognostic analysis.World J Surg2004https://conductscience.org/library/papers/14994148PubMed
10,476,906Growth inhibition of human liver cancer cells by alpha-fetoprotein antisense strategy.In Vitro Cell Dev Biol Anim1999https://conductscience.org/library/papers/10476906PubMed
7,044,972Corticosterone regulation of the effector function of malarial immunity during pregnancy.Infect Immun1982https://conductscience.org/library/papers/7044972PubMed
6,995,314Depressed malarial immunity in pregnant mice.Infect Immun1980https://conductscience.org/library/papers/6995314PubMed
6,455,226Maternal regulator cells during murine pregnancy.Clin Exp Immunol1981https://conductscience.org/library/papers/6455226PubMed
6,231,146Spontaneous suppressor cell activity in the peripheral blood of patients with malignant and chronic inflammatory bowel diseases.Clin Exp Immunol1984https://conductscience.org/library/papers/6231146PubMed
6,158,053Inhibitory effect of alpha-fetoprotein on the binding of myasthenia gravis antibody to acetylcholine receptor.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6158053PubMed
2,475,575Isolation and characterization of a distinct immunoregulatory isoform of alpha-fetoprotein produced by the normal fetus.J Exp Med1989https://conductscience.org/library/papers/2475575PubMed
1,829,989Immunological tolerance induced by liver grafting in the rat: splenic macrophages and T cells mediate distinct phases of immunosuppressive activity.Clin Exp Immunol1991https://conductscience.org/library/papers/1829989PubMed
1,383,274Isolation and partial characterization of a specific alpha-fetoprotein receptor on human monocytes.J Clin Invest1992https://conductscience.org/library/papers/1383274PubMed
371,881Facilitation reaction (enhancing antibodies and suppressor cells) and rejection reaction (sensitized cells) from the mother to the paternal antigens of the conceptus.Clin Exp Immunol1979https://conductscience.org/library/papers/371881PubMed
312,895Localization of H-2 antigens on mouse trophoblast cells.J Exp Med1979https://conductscience.org/library/papers/312895PubMed
312,271Suppression of antibody responses by cells from mice painted with picryl chloride.Immunology1979https://conductscience.org/library/papers/312271PubMed
310,079Suppression of human T-cell colony formation during pregnancy.Nature1978https://conductscience.org/library/papers/310079PubMed

See all 25 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
AFP174PubTator's text mininghttps://conductscience.org/library/genes/174

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • References
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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