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Paper6933461

Prevalent deficiency in tumor cells of cycloheximide-induced cycle arrest.

Medrano EE and 1 other. Proc Natl Acad Sci U S A, 1980. Cited by 89 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Prevalent deficiency in tumor cells of cycloheximide-induced cycle arrest. Papers, record 6933461. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6933461

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Prevalent deficiency in tumor cells of cycloheximide-induced cycle arrest.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1980
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
89
iCite
Relative citation ratio, by iCite
1.63
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Medrano EEE E
2Pardee ABA B

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell CycleMajor topic
Cell Transformation, NeoplasticMajor topic
CycloheximideMajor topic
DNA ReplicationMajor topic
Animals
Cell Line
Cricetinae
Dose-Response Relationship, Drug
Humans
Mice
Protein Biosynthesis

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
GM 24571NIGMS NIH HHSUnited StatesR01GM024571PubMed and NIHNIH RePORTER
TW02800FIC NIH HHSUnited StatesF05TW002800PubMed and NIHNIH RePORTER

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,301,006Development of 3T3-like lines from Balb-c mouse embryo cultures: transformation susceptibility to SV40.J Cell Physiol1968https://conductscience.org/library/papers/4301006PubMed
25,106,077Inhibition of DNA synthesis in synchronized Chinese hamster cells treated in G1 with cycloheximide.Exp Cell Res1971https://conductscience.org/library/papers/5106077PubMed
34,674,691Inhibition of DNA synthesis in synchronized Chinese hamster cells treated in G1 or early S phase with cycloheximide or puromycin.Exp Cell Res1972https://conductscience.org/library/papers/4674691PubMed
44,685,994Selective inhibition of the cell cycle of cultured human diploid fibroblasts by aminonucleoside of puromycin.J Cell Physiol1973https://conductscience.org/library/papers/4685994PubMed
54,357,883Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4357883PubMed
64,817,725Incorporation of 3H-uridine and 3H-uracil into RNA: a simple technique for the detection of mycoplasma contamination of cultured cells.Exp Cell Res1974https://conductscience.org/library/papers/4817725PubMed
74,822,526Changes in the uptake of 2-deoxy-D-glucose in BALB-3T3 cells chemically transformed in culture.J Cell Physiol1974https://conductscience.org/library/papers/4822526PubMed
84,524,638A restriction point for control of normal animal cell proliferation.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4524638PubMed
91,115,785A requirement for RNA, protein and DNA synthesis in the establishment of DNA replicase activity in synchronized HeLa cells.Biochim Biophys Acta1975https://conductscience.org/library/papers/1115785PubMed
101,105,198Control of growth of mammalian cells in cell culture.Nature1975https://conductscience.org/library/papers/1105198PubMed
111,061,701The biology of human cells in tissue culture. I. Characterization of cells derived from osteogenic sarcomas.Int J Cancer1976https://conductscience.org/library/papers/1061701PubMed
12184,467Control of growth of benzo(a)pyrene-transformed 3T3 cells.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/184467PubMed
1362,589Endogenous type-C RNA viruses of mammalian cells.Biochim Biophys Acta1976https://conductscience.org/library/papers/62589PubMed
14187,944Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells.Nature1976https://conductscience.org/library/papers/187944PubMed
15902,318Continuous protein synthesis is required to maintain the probability of entry into S phase.Cell1977https://conductscience.org/library/papers/902318PubMed
16679,990Arrested states produced by isoleucine deprivation and their relationship to the low serum produced arrested state in Swiss 3T3 cells.Exp Cell Res1978https://conductscience.org/library/papers/679990PubMed
17688,399The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts.Cell1978https://conductscience.org/library/papers/688399PubMed
18694,725Genetic analysis of tumorigenesis: I. Expression of tumor-forming ability in hamster hybrid cell lines.Somatic Cell Genet1978https://conductscience.org/library/papers/694725PubMed
19215,597Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor.J Cell Physiol1978https://conductscience.org/library/papers/215597PubMed
20445,475Different responses to drugs and serum of cells transformed by various means.Cancer Res1979https://conductscience.org/library/papers/445475PubMed

See all 24 references

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 89 citations.

PMIDTitleJournalYearIn PapersSource
34,566,949Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-Inflammatory Cytokines.Front Immunol2021https://conductscience.org/library/papers/34566949PubMed
28,243,278Human Lung Carcinoma Reaction against Metabolic Serum Deficiency Stress.Iran J Pharm Res2016https://conductscience.org/library/papers/28243278PubMed
26,625,317Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells.Oncotarget2016https://conductscience.org/library/papers/26625317PubMed
26,462,035Inhibitor of apoptosis proteins as intracellular signaling intermediates.FEBS J2016https://conductscience.org/library/papers/26462035PubMed
15,972,482Development of secondary inclusions in cells infected by Chlamydia trachomatis.Infect Immun2005https://conductscience.org/library/papers/15972482PubMed
11,342,457Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation.Blood2001https://conductscience.org/library/papers/11342457PubMed
10,949,947n-Butyrate mediated inhibition of papovavirus DNA replication in vivo and in cell culture: a mechanistic approach.Virus Genes2000https://conductscience.org/library/papers/10949947PubMed
8,895,573The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.EMBO J1996https://conductscience.org/library/papers/8895573PubMed
8,628,308Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts.Mol Cell Biol1996https://conductscience.org/library/papers/8628308PubMed
8,035,479n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses.J Virol1994https://conductscience.org/library/papers/8035479PubMed
7,499,104Preclinical antitumor activity of ethyldeshydroxysparsomycin in combination with cisplatin.Invest New Drugs1995https://conductscience.org/library/papers/7499104PubMed
6,957,863Carcinogen-transformed human cells are inhibited from entry into S phase by fusion to senescent cells but cells transformed by DNA tumor viruses overcome the inhibition.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6957863PubMed
6,952,194Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6952194PubMed
6,841,314Podospora mutant defective in glucose-dependent growth control.J Bacteriol1983https://conductscience.org/library/papers/6841314PubMed
6,646,125Delayed processing of dihydrofolate reductase heterogeneous nuclear RNA in amino acid-starved mouse fibroblasts.Mol Cell Biol1983https://conductscience.org/library/papers/6646125PubMed
6,325,878Energy requirement for degradation of tumor-associated protein p53.Mol Cell Biol1984https://conductscience.org/library/papers/6325878PubMed
6,308,643Enhanced synthesis and stabilization of Mr 68,000 protein in transformed BALB/c-3T3 cells: candidate for restriction point control of cell growth.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6308643PubMed
3,860,868Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3860868PubMed
2,823,120Topoisomerase-specific drug sensitivity in relation to cell cycle progression.Mol Cell Biol1987https://conductscience.org/library/papers/2823120PubMed
2,251,273Transformed and nontransformed cells differ in stability and cell cycle regulation of a binding activity to the murine thymidine kinase promoter.Proc Natl Acad Sci U S A1990https://conductscience.org/library/papers/2251273PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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