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Paper · 6953009

Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production.

Rainsford KD and 1 other. Dig Dis Sci, 1982. Cited by 136 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production. Papers, record 6953009. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6953009

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production.
PubMed
Journal
Dig Dis Sci
PubMed
Year
1982
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
136
iCite
Relative citation ratio, by iCite
5.99
iCite
Revised in PubMed
2019-07-21
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Rainsford KDK D
2Willis CC

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Anti-Inflammatory AgentsMajor topic
Gastric MucosaMajor topic
ProstaglandinsMajor topic
Animals
Dinoprostone
Dose-Response Relationship, Drug
Female
Hydrogen-Ion Concentration
Indomethacin
Prostaglandins E
Prostaglandins F
Swine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,107Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins.Eur J Pharmacol1976https://conductscience.org/library/papers/11107PubMed
21,980The biochemical pathology of aspirin-induced gastric damage.Agents Actions1975https://conductscience.org/library/papers/1980PubMed
34,208,101Drugs which inhibit prostaglandin biosynthesis.Pharmacol Rev1974https://conductscience.org/library/papers/4208101PubMed
44,765,037The count of mast cells, tissue eosinophils, and epithelial mitoses of rat gastrointestinal mucosa after aspirin treatment.Acta Physiol Scand1973https://conductscience.org/library/papers/4765037PubMed
5856,290Distribution of prostaglandin biosynthetic pathways in several rat tissues. Formation of 6-ketoprostaglandin F1alpha.Biochim Biophys Acta1977https://conductscience.org/library/papers/856290PubMed
6167,892Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs.Br J Pharmacol1975https://conductscience.org/library/papers/167892PubMed
74,439,208Effects of aspirin on canine gastric prostaglandin output and mucosal permeability.Surg Forum1974https://conductscience.org/library/papers/4439208PubMed
8456,839Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.Gastroenterology1979https://conductscience.org/library/papers/456839PubMed
914,204,817PATHOLOGY OF GASTRIC ULCERS IN SWINE.Am J Vet Res1964https://conductscience.org/library/papers/14204817PubMed
101,158,188Electronmicroscopic observations on the effects of orally administered aspirin and aspirin-bicarbonate mixtures on the development of gastric mucosal damage in the rat.Gut1975https://conductscience.org/library/papers/1158188PubMed

1 to 10 of 42

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Cited by31

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 136 citations.

PMIDTitleJournalYearIn PapersSource
26,977,301Role of endoplasmic reticulum stress in drug-induced toxicity.Pharmacol Res Perspect2016https://conductscience.org/library/papers/26977301PubMed
25,561,799Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats.World J Gastroenterol2014https://conductscience.org/library/papers/25561799PubMed
25,221,653Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.ACS Med Chem Lett2014https://conductscience.org/library/papers/25221653PubMed
23,002,337Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa.World J Gastroenterol2012https://conductscience.org/library/papers/23002337PubMed
22,509,079Curcumin prevents indomethacin-induced gastropathy in rats.World J Gastroenterol2012https://conductscience.org/library/papers/22509079PubMed
21,627,632NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies.Br J Pharmacol2012https://conductscience.org/library/papers/21627632PubMed
18,484,783Safety of the nonselective NSAID nabumetone : focus on gastrointestinal tolerability.Drug Saf2008https://conductscience.org/library/papers/18484783PubMed
15,456,329Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis.Drugs2004https://conductscience.org/library/papers/15456329PubMed
10,486,359Indomethacin induced gastropathy in CD18, intercellular adhesion molecule 1, or P-selectin deficient mice.Gut1999https://conductscience.org/library/papers/10486359PubMed
8,949,638Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.Gut1996https://conductscience.org/library/papers/8949638PubMed

1 to 10 of 31

See all 31 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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