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Paper · 6965397

Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen.

Kelsoe G and 2 others. J Exp Med, 1980. Cited by 84 papers, by iCite.

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ConductScience Library. Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen. Papers, record 6965397. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6965397

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen.
PubMed
Journal
J Exp Med
PubMed
Year
1980
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
84
iCite
Relative citation ratio, by iCite
1.91
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kelsoe GG
2Isaak DD
3Cerny JJ

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody-Producing CellsMajor topic
Immunoglobulin IdiotypesMajor topic
T-LymphocytesMajor topic
Animals
Antigens, Bacterial
Female
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Spleen
Streptococcus pneumoniae
Thymus Gland
Time Factors
Transplantation, Isogeneic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1270,748Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/270748PubMed
253,257Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.J Exp Med1975https://conductscience.org/library/papers/53257PubMed
34,142,565Towards a network theory of the immune system.Ann Immunol (Paris)1974https://conductscience.org/library/papers/4142565PubMed
4303,775Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/303775PubMed
54,586,979A cyclical appearance of antibody-producing cells after a single injection of serum protein antigen.J Exp Med1973https://conductscience.org/library/papers/4586979PubMed
65,762,048Cell interactions in the primary immune response in vitro: a requirement for specific cell clusters.J Exp Med1969https://conductscience.org/library/papers/5762048PubMed
74,143,481The immune system: a web of V-domains.Harvey Lect1974https://conductscience.org/library/papers/4143481PubMed
85,954,775Antibody production studied by means of the LHG assay. I. The splenic response of CBA mice to sheep erythrocytes.Immunology1966https://conductscience.org/library/papers/5954775PubMed
913,931,034The chemical composition of pneumococcal C-polysaccharide.J Biol Chem1963https://conductscience.org/library/papers/13931034PubMed
104,632,943Cyclical variations in anti-Rh titer detected by automatic quantitative hemagglutination.Vox Sang1972https://conductscience.org/library/papers/4632943PubMed

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Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 84 citations.

PMIDTitleJournalYearIn PapersSource
8,652,362In vivo and in vitro study of the primary and secondary antibody response to a bacterial antigen in aged mice.Int J Exp Pathol1995https://conductscience.org/library/papers/8652362PubMed
8,199,004Increase of cross(auto)-reactive antibodies after immunization in aged mice: a cellular and molecular study.Int J Exp Pathol1994https://conductscience.org/library/papers/8199004PubMed
7,019,378Idiotype profile of an immune response. I. Contrasts in idiotypic dominance between primary and secondary responses and between IgM and IgG plaque-forming cells.J Exp Med1981https://conductscience.org/library/papers/7019378PubMed
6,972,994Generation of idiotype-specific T cell help through network perturbation.J Exp Med1981https://conductscience.org/library/papers/6972994PubMed
6,808,074Regulatory idiotypes. T helper cells recognize a shared VH idiotope on phosphorylcholine-specific antibodies.J Exp Med1982https://conductscience.org/library/papers/6808074PubMed
6,603,934
Characterization of anti-Fab' antibodies in human sera: identification of soluble immune complexes that contain hidden anti-KLH and blocking anti-immunoglobulins following immunization with keyhole limpet haemocyanin.
Clin Exp Immunol1983https://conductscience.org/library/papers/6603934PubMed
6,454,747Regulation by complementary idiotypes. Ig protects the clone producing it.J Exp Med1981https://conductscience.org/library/papers/6454747PubMed
6,222,133Induction of idiotype-specific suppressor T cells with antigen/antibody complexes.J Exp Med1983https://conductscience.org/library/papers/6222133PubMed
6,213,731Immunoglobulin idiotopes expressed by T cells. I. Expression of distinct idiotopes detected by monoclonal antibodies on antigen-specific suppressor T cells.J Exp Med1982https://conductscience.org/library/papers/6213731PubMed
6,198,421Non-dinitrophenyl-binding immunoglobulin that bears a dominant idiotype (Id460) associated with antidinitrophenyl antibody is specific for an antigen on Pasteurella pneumotropica.J Exp Med1984https://conductscience.org/library/papers/6198421PubMed

1 to 10 of 15

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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