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Paper6970751

Chronic lymphocytic leukemia cells lack the 185,000-dalton macromolecular insoluble cold globulin present on normal B lymphocytes.

Simmonds MA and 2 others. J Clin Invest, 1981. Cited by 12 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Chronic lymphocytic leukemia cells lack the 185,000-dalton macromolecular insoluble cold globulin present on normal B lymphocytes. Papers, record 6970751. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6970751

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Chronic lymphocytic leukemia cells lack the 185,000-dalton macromolecular insoluble cold globulin present on normal B lymphocytes.
PubMed
Journal
J Clin Invest
PubMed
Year
1981
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
12
iCite
Relative citation ratio, by iCite
0.42
iCite
Revised in PubMed
2018-11-13
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Simmonds MAM A
2Sobczak GG
3Hauptman SPS P

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
FibronectinsMajor topic
Leukemia, LymphoidMajor topic
Neoplasm ProteinsMajor topic
Cell Membrane
Cell Transformation, Neoplastic
Humans
Molecular Weight
Receptors, Antigen, B-Cell
T-Lymphocytes

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AM 07084NIADDK NIH HHSUnited StatesPubMedPubMed
CA 26369-01NCI NIH HHSUnited StatesPubMedPubMed
R01CA026369NIHNIH RePORTER

References45

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,179,068Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.Scand J Clin Lab Invest Suppl1968https://conductscience.org/library/papers/4179068PubMed
24,182,405An immunofluorescence procedure for the detection of intracellular immunoglobulins.Clin Exp Immunol1969https://conductscience.org/library/papers/4182405PubMed
34,189,836Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunits.J Exp Med1970https://conductscience.org/library/papers/4189836PubMed
44,919,141Immunoglobulin spots on the surface of rabbit lymphocytes.J Exp Med1970https://conductscience.org/library/papers/4919141PubMed
54,101,362A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization.J Exp Med1970https://conductscience.org/library/papers/4101362PubMed
65,102,530Synthesis, assembly and secretion of gamma globulin by mouse myeloma cells. II. Assembly of IgG2b immunoglobulin by MPC 11 tumor and culture cells.J Mol Biol1971https://conductscience.org/library/papers/5102530PubMed
74,502,405Selective stimulation of IgM synthesis in mouse B lymphocytes by pokeweed mitogen.Nat New Biol1972https://conductscience.org/library/papers/4502405PubMed
84,556,902Immunoglobulins on the surface of neoplastic lymphocytes.N Engl J Med1972https://conductscience.org/library/papers/4556902PubMed
94,115,311Anti-human immunoglobulin G activity of membrane-bound monoclonal immunoglobulin M in lymphoproliferative disorders.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4115311PubMed
104,628,444Surface bound immunoglobulins as a cell marker in human lymphoproliferative diseases.Blood1972https://conductscience.org/library/papers/4628444PubMed
114,567,307Combined studies of complement receptor and surface immunoglobulin-bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes.J Clin Invest1973https://conductscience.org/library/papers/4567307PubMed
124,568,727Induction of immunoglobulin M synthesis and secretion in bone-marrow-derived lymphocytes by locally concentrated concanavalin A.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4568727PubMed
134,540,356Lymphocyte activation. IV. The ultrastructural pattern of the response of mouse T and B cells to mitogenic stimulation in vitro.Immunology1973https://conductscience.org/library/papers/4540356PubMed
144,124,688Cell-surface immunoglobulins in chronic lymphocytic leukemia and allied disorders.Am J Med1973https://conductscience.org/library/papers/4124688PubMed
154,542,737Immunoglobulin D as a lymphocyte receptor.J Exp Med1973https://conductscience.org/library/papers/4542737PubMed
164,589,993Occurrence of surface IgM, IgD, and free light chains of human lymphocytes.J Exp Med1974https://conductscience.org/library/papers/4589993PubMed
174,544,194Purification of human T and B lymphocytes.J Immunol1974https://conductscience.org/library/papers/4544194PubMed
184,855,863A monoclonal IgM protein with antibody-like activity for human albumin.J Clin Invest1974https://conductscience.org/library/papers/4855863PubMed
194,829,935Cell surface immunoglobulin. IX. A new method for the study of synthesis, intracellular transport, and exteriorization in murine splenocytes.J Exp Med1974https://conductscience.org/library/papers/4829935PubMed
204,857,904Antibodies to human albumin in cirrhotic sera.J Clin Invest1974https://conductscience.org/library/papers/4857904PubMed

See all 45 references

Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 12 citations.

PMIDTitleJournalYearIn Papers
6,610,691Multicomponent analysis of amino acid transport in human lymphocytes. Diminished L-system transport in chronic leukemic B lymphocytes.J Clin Invest1984https://conductscience.org/library/papers/6610691

Source PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
MICG352,967PubTator's text mininghttps://conductscience.org/library/genes/352967

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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