Paper · 6973604

Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity.

Granelli-Piperno A and 2 others. J Exp Med, 1981. Cited by 53 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity. Papers, record 6973604. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6973604

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity.; PubMed
Journal: J Exp Med; PubMed
Year: 1981; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6973604/; PubMed
DOI: https://doi.org/10.1084/jem.154.2.422; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2186437/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 53; iCite
Relative citation ratio, by iCite: 1.39; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Granelli-Piperno A	A
2	Vassalli JD	J D
3	Reich E	E

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Interleukin-2	Major topic
Lymphokines	Major topic
Animals
Chromatography, Ion Exchange
Dose-Response Relationship, Immunologic
Electrophoresis, Polyacrylamide Gel
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Mice, Nude
Sodium Dodecyl Sulfate

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
CA-08290	NCI NIH HHS	United States		PubMed
GM-07245	NIGMS NIH HHS	United States		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,034,749	Immunization of dissociated spleen cell cultures from normal mice.	J Exp Med	1967	https://conductscience.org/library/papers/6034749	PubMed
2	6,450,803	Soluble suppressor supernatants elaborated by concanavalin A-activated human mononuclear cells. I. Characterization of a soluble suppressor T cell proliferation.	J Immunol	1981	https://conductscience.org/library/papers/6450803	PubMed
3	4,592,599	Biological expressions of lymphocyte activation. 3. Suppression of plaque-forming cell responses in vitro by supernatant fluids from concanavalin A-activated spleen cell cultures.	J Immunol	1974	https://conductscience.org/library/papers/4592599	PubMed
4	942,051	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	Anal Biochem	1976	https://conductscience.org/library/papers/942051	PubMed
5	833,546	Macrophage plasminogen activator: induction by products of activated lymphoid cells.	J Exp Med	1977	https://conductscience.org/library/papers/833546	PubMed
6	303,772	Activation of cytotoxic T cells by nonstimulating tumor cells and spleen cell factor(s).	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/303772	PubMed
7	145,543	Long term culture of tumour-specific cytotoxic T cells.	Nature	1977	https://conductscience.org/library/papers/145543	PubMed
8	310,827	The purification and quantitation of helper T cell-replacing factors secreted by murine spleen cells activated by concanavalin A.	J Immunol	1979	https://conductscience.org/library/papers/310827	PubMed
9	109,511	Molecular and quantitative analysis of helper T cell-replacing factors on the induction of antigen-sensitive B and T lymphocytes.	J Immunol	1979	https://conductscience.org/library/papers/109511	PubMed
10	312,860	Physicochemical characterization of lymphocyte-activating factor (LAF).	J Immunol	1979	https://conductscience.org/library/papers/312860	PubMed

1 to 10 of 18

See all 18 references

Cited by16

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 53 citations.

PMID	Title	Journal	Year	In Papers	Source
6,980,256	Purification of human interleukin 2 to apparent homogeneity and its molecular heterogeneity.	J Exp Med	1982	https://conductscience.org/library/papers/6980256	PubMed
6,608,103	Purification to homogeneity and partial characterization of interleukin 2 from a human T-cell leukemia.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6608103	PubMed
6,607,316	Cytotoxic T cells both produce and respond to interleukin 2.	J Exp Med	1984	https://conductscience.org/library/papers/6607316	PubMed
6,601,512	Growth inhibition of an MC-induced mouse sarcoma by TCGF (IL 2)-containing preparations. Preliminary report.	Cancer Immunol Immunother	1983	https://conductscience.org/library/papers/6601512	PubMed
6,417,263	Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2.	J Exp Med	1983	https://conductscience.org/library/papers/6417263	PubMed
6,376,356	In vivo and in vitro administration of interleukin 2-containing preparation reverses T-cell unresponsiveness in Mycobacterium bovis BCG-infected mice.	Infect Immun	1984	https://conductscience.org/library/papers/6376356	PubMed
6,334,715	Stimulation of lymphokine release from T lymphoblasts. Requirement for mRNA synthesis and inhibition by cyclosporin A.	J Exp Med	1984	https://conductscience.org/library/papers/6334715	PubMed
6,300,278	Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation.	J Exp Med	1983	https://conductscience.org/library/papers/6300278	PubMed
6,236,276	Antibodies to interleukin 2. Effects on immune responses in vitro and in vivo.	J Exp Med	1984	https://conductscience.org/library/papers/6236276	PubMed
6,228,520	Suppressor cells induced by BCG release non-specific factors in vitro which inhibit DNA synthesis and interleukin-2 production.	Immunology	1984	https://conductscience.org/library/papers/6228520	PubMed

1 to 10 of 16

See all 16 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/6973604

GET https://conductscience.org/api/papers/v1/6973604/authors

API reference For AI assistants