Paper · 6975347

T cell growth factor receptors. Quantitation, specificity, and biological relevance.

Robb RJ and 2 others. J Exp Med, 1981. Cited by 1,303 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. T cell growth factor receptors. Quantitation, specificity, and biological relevance. Papers, record 6975347. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6975347

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: T cell growth factor receptors. Quantitation, specificity, and biological relevance.; PubMed
Journal: J Exp Med; PubMed
Year: 1981; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6975347/; PubMed
DOI: https://doi.org/10.1084/jem.154.5.1455; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2186509/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 1,303; iCite
Relative citation ratio, by iCite: 30.2; iCite
Revised in PubMed: 2020-12-15; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Robb RJ	R J
2	Munck A	A
3	Smith KA	K A

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Interleukin-2	Major topic
Lymphokines	Major topic
Animals
Binding Sites
Binding, Competitive
Cattle
Cell Line
Chemical Phenomena
Chemistry
Cytotoxicity, Immunologic
Humans
Isoelectric Focusing
Lymphocyte Activation
Methionine
Mice
Mice, Inbred Strains
Phytohemagglutinins
Rats
Time Factors

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
CA-17323	NCI NIH HHS	United States	R01CA017323	PubMed and NIH	NIH RePORTER
CA-17643	NCI NIH HHS	United States	R01CA017643	PubMed and NIH	NIH RePORTER
CA-23108	NCI NIH HHS	United States	P30CA023108	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References41

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	7,000,675	Clones of killer and helper T cells: growth requirements, specificity and retention of function in long-term culture.	Immunol Rev	1980	https://conductscience.org/library/papers/7000675	PubMed
2	7,000,673	Interleukin 2: a class of T cell growth factors.	Immunol Rev	1980	https://conductscience.org/library/papers/7000673	PubMed
3	6,776,414	Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells.	Nature	1980	https://conductscience.org/library/papers/6776414	PubMed
4	6,778,951	Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.	J Exp Med	1980	https://conductscience.org/library/papers/6778951	PubMed
5	7,007,369	On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell.	J Biol Chem	1981	https://conductscience.org/library/papers/7007369	PubMed
6	6,451,643	Mechanism of T cell activation. II. Antigen- and lectin-dependent acquisition of responsiveness to TCGF is a nonmitogenic, active response of resting T cells.	J Immunol	1981	https://conductscience.org/library/papers/6451643	PubMed
7	6,260,804	Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. A direct biochemical and morphologic demonstration.	J Biol Chem	1981	https://conductscience.org/library/papers/6260804	PubMed
8	6,971,398	Functional and molecular characteristics of T-cell growth factor.	Mol Immunol	1980	https://conductscience.org/library/papers/6971398	PubMed
9	6,787,609	Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen.	Proc Natl Acad Sci U S A	1981	https://conductscience.org/library/papers/6787609	PubMed
10	6,169,447	A permanent human cytotoxic T-cell line with high killing capacity against a lymphoblastoid B-cell line shows preference for HLA A, B target antigens and lacks spontaneous cytotoxic activity.	Cell Immunol	1981	https://conductscience.org/library/papers/6169447	PubMed

1 to 10 of 41

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Cited by280

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,303 citations.

PMID	Title	Journal	Year	In Papers	Source
41,510,098	OX40L and IL-2 combination strategy for gastric cancer immunotherapy.	Transl Cancer Res	2025	https://conductscience.org/library/papers/41510098	PubMed
41,361,892	Mutant IL-2-expressing mesenchymal stromal cells promote regulatory T cells proliferation and activation in collagen induced arthritis mice.	Arthritis Res Ther	2025	https://conductscience.org/library/papers/41361892	PubMed
40,680,114	BLIMP1 negatively regulates IL-2 signaling in T cells.	Sci Adv	2025	https://conductscience.org/library/papers/40680114	PubMed
36,636,297	Peripheral Blood Mononuclear Cell Cytokine mRNA Profiles in Acute Respiratory Infection Patients.	J Glob Infect Dis	2022	https://conductscience.org/library/papers/36636297	PubMed
35,846,741	Chicken-Specific Kinome Analysis of Early Host Immune Signaling Pathways in the Cecum of Newly Hatched Chickens Infected With Salmonella enterica Serovar Enteritidis.	Front Cell Infect Microbiol	2022	https://conductscience.org/library/papers/35846741	PubMed
33,523,442	Regulation of Treg Functions by the Ubiquitin Pathway.	Adv Exp Med Biol	2021	https://conductscience.org/library/papers/33523442	PubMed
31,811,270	Treg cell-based therapies: challenges and perspectives.	Nat Rev Immunol	2020	https://conductscience.org/library/papers/31811270	PubMed
31,611,250	Effects of interleukin-2 in immunostimulation and immunosuppression.	J Exp Med	2020	https://conductscience.org/library/papers/31611250	PubMed
30,089,912	Biology and regulation of IL-2: from molecular mechanisms to human therapy.	Nat Rev Immunol	2018	https://conductscience.org/library/papers/30089912	PubMed
29,854,806	Prospects of IL-2 in Cancer Immunotherapy.	Biomed Res Int	2018	https://conductscience.org/library/papers/29854806	PubMed

1 to 10 of 280

See all 280 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
IL2	3,558	PubTator's text mining	https://conductscience.org/library/genes/3558

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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