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Paper · 6977611

T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch.

Mongini PK and 2 others. J Exp Med, 1982. Cited by 131 papers, by iCite.

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ConductScience Library. T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch. Papers, record 6977611. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6977611

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch.
PubMed
Journal
J Exp Med
PubMed
Year
1982
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
131
iCite
Relative citation ratio, by iCite
2.98
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Mongini PKP K
2Paul WEW E
3Metcalf ESE S

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
FicollMajor topic
ImmunoglobulinsMajor topic
NitrobenzenesMajor topic
PolysaccharidesMajor topic
T-LymphocytesMajor topic
TrinitrobenzenesMajor topic
Animals
Antibody Affinity
Antigens, Heterophile
B-Lymphocytes
Clone Cells
Immunoglobulin G
Mice
Mice, Inbred C57BL
Mice, Nude
Spleen
Time Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT05345197Emicizumab in Patients With Acquired Hemophilia ABackground

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,925,708Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins.J Immunol1966https://conductscience.org/library/papers/5925708PubMed
25,722,148Thymus dependence of antibody response: variation with dose of antigen and class of antibody.Nature1968https://conductscience.org/library/papers/5722148PubMed
34,102,405The stimulation of splenic foci in vitro.J Immunol1971https://conductscience.org/library/papers/4102405PubMed
44,550,607Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys.J Exp Med1972https://conductscience.org/library/papers/4550607PubMed
54,126,287Regulation of antibody response in vitro. VI. Carrier-specific helper cells for IgG and IgE antibody response.J Immunol1973https://conductscience.org/library/papers/4126287PubMed
64,273,650Mode of action of a supernatant activity from T-cell cultures that nonspecifically stimulates the humoral immune response.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4273650PubMed
757,834Further studies on Th-B, a cell surface antigenic determinant present on mouse B cells, plasma cells and immature thymocytes.Cell Immunol1976https://conductscience.org/library/papers/57834PubMed
81,085,324T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.J Exp Med1976https://conductscience.org/library/papers/1085324PubMed
915,036Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin.J Immunol Methods1977https://conductscience.org/library/papers/15036PubMed
10336,521IgG anti-hapten antibody secretion in vitro commences after extensive precursor proliferation.Immunology1977https://conductscience.org/library/papers/336521PubMed

1 to 10 of 31

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Cited by37

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 131 citations.

PMIDTitleJournalYearIn PapersSource
30,402,329Expansion and Sub-Classification of T Cell-Dependent Antibody Responses to Encompass the Role of Innate-Like T Cells in Antibody Responses.Immune Netw2018https://conductscience.org/library/papers/30402329PubMed
22,945,808Division of labor during primary humoral immunity.Immunol Res2013https://conductscience.org/library/papers/22945808PubMed
22,658,901Influenza M1 VLPs containing neuraminidase induce heterosubtypic cross-protection.Virology2012https://conductscience.org/library/papers/22658901PubMed
22,531,925Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action.Eur J Immunol2012https://conductscience.org/library/papers/22531925PubMed
15,379,979Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction.Immunology2004https://conductscience.org/library/papers/15379979PubMed
8,958,064
The autoimmunogenic chemicals HgCl2 and diphenylhydantoin stimulate IgG production to TNP-Ficoll and TNP-OVA, supporting and extending the graft-versus-host hypothesis for chemical induction of autoimmunity.
Immunology1996https://conductscience.org/library/papers/8958064PubMed
7,536,930B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.Proc Natl Acad Sci U S A1995https://conductscience.org/library/papers/7536930PubMed
6,822,787Macrophage activation selectively enhances expression of Fc receptors for IgG2a.J Exp Med1983https://conductscience.org/library/papers/6822787PubMed
6,609,396Control of B cell differentiation by T cells.Surv Immunol Res1983https://conductscience.org/library/papers/6609396PubMed
6,605,368Hyper IgM immunodeficiency. A primary dysfunction of B lymphocyte isotype switching.J Clin Invest1983https://conductscience.org/library/papers/6605368PubMed

1 to 10 of 37

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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