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Paper · 6983073

Antigen-specific human T-cell hybridomas with helper activity.

DeFreitas EC and 5 others. Proc Natl Acad Sci U S A, 1982. Cited by 22 papers, by iCite.

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ConductScience Library. Antigen-specific human T-cell hybridomas with helper activity. Papers, record 6983073. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6983073

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Antigen-specific human T-cell hybridomas with helper activity.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1982
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
22
iCite
Relative citation ratio, by iCite
0.68
iCite
Revised in PubMed
2019-05-01
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1DeFreitas ECE C
2Vella SS
3Linnenbach AA
4Zmijewski CC
5Koprowski HH
6Croce CMC M

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
HybridomasMajor topic
Lymphocyte CooperationMajor topic
T-LymphocytesMajor topic
Antibody Formation
B-Lymphocytes
Cell Line
Humans
Interleukin-2
Receptors, Antigen, T-Cell
Tetanus Toxoid

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
CA 10815NCI NIH HHSUnited StatesP01CA010815PubMed and NIHNIH RePORTER
CA 20741NCI NIH HHSUnited StatesR01CA020741PubMed and NIHNIH RePORTER
CA 21069NCI NIH HHSUnited StatesP01CA021069PubMed and NIHNIH RePORTER
P30CA010815NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,034,749Immunization of dissociated spleen cell cultures from normal mice.J Exp Med1967https://conductscience.org/library/papers/6034749PubMed
24,107,917A rapid banding technique for human chromosomes.Lancet1971https://conductscience.org/library/papers/4107917PubMed
34,114,496Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.J Exp Med1972https://conductscience.org/library/papers/4114496PubMed
44,361,084Unidirectional loss of human chromosomes in rat-human hybrids.Exp Cell Res1973https://conductscience.org/library/papers/4361084PubMed
5181,845Selective in vitro growth of T lymphocytes from normal human bone marrows.Science1976https://conductscience.org/library/papers/181845PubMed
6825,573Analysis of parameters affecting the solid phase radioimmunoassay quantitation of antibody to meningococcal antigens.J Immunol1976https://conductscience.org/library/papers/825573PubMed
7300,757Specific binding of T lymphocytes to macrophages. I. Kinetics of binding.J Immunol1977https://conductscience.org/library/papers/300757PubMed
870,838Macrophage-dependent response of immune human T lymphocytes to PPD in vitro. Influence of HLA-D histocompatibility.Scand J Immunol1977https://conductscience.org/library/papers/70838PubMed
9307,029T cell growth factor: parameters of production and a quantitative microassay for activity.J Immunol1978https://conductscience.org/library/papers/307029PubMed
10307,689T-cell lines producing antigen-specific suppressor factor.Nature1978https://conductscience.org/library/papers/307689PubMed

1 to 10 of 27

See all 27 references

Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 22 citations.

PMIDTitleJournalYearIn PapersSource
6,609,121Characterization of a human X mouse T cell hybridoma and identification of a clone secreting and binding interleukin-2.Immunology1984https://conductscience.org/library/papers/6609121PubMed
6,582,477Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6582477PubMed
6,231,643Formation of IgE-binding factors by human T-cell hybridomas.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6231643PubMed
6,209,205Human T-cell hybrids with HLA-restricted proliferative response to Epstein-Barr virus-infected B cells.Immunology1984https://conductscience.org/library/papers/6209205PubMed
3,929,254Interleukin 2 promotes growth and cytolytic activity in human T3+4-8- thymocytes.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3929254PubMed
2,786,203Idiotypic cascades in cancer patients treated with monoclonal antibody CO17-1A.Proc Natl Acad Sci U S A1989https://conductscience.org/library/papers/2786203PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
IL23,558PubTator's text mininghttps://conductscience.org/library/genes/3558

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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