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Paper · 7192534

Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir.

St Clair MH and 3 others. Antimicrob Agents Chemother, 1980. Cited by 85 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir. Papers, record 7192534. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7192534

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir.
PubMed
Journal
Antimicrob Agents Chemother
PubMed
Year
1980
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
85
iCite
Relative citation ratio, by iCite
2.92
iCite
Revised in PubMed
2021-05-26
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1St Clair MHM H
2Furman PAP A
3Lubbers CMC M
4Elion GBG B

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AcyclovirMajor topic
Antiviral AgentsMajor topic
GuanineMajor topic
Nucleic Acid Synthesis InhibitorsMajor topic
Cell Survival
DNA Polymerase II
Humans
Kinetics
Viral Plaque Assay
Virus Replication
Viruses

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,804,948Separation of a new deoxyribonucleic acid polymerase from vaccinia-infected HeLa cells.J Virol1969https://conductscience.org/library/papers/5804948PubMed
25,476,915Kinetics and intermediates in the intracellular synthesis of bacteriophage T4 deoxyribonucleic acid.J Mol Biol1970https://conductscience.org/library/papers/5476915PubMed
34,925,356Rapid cell culture assay technic for murine leukaemia viruses.Nature1971https://conductscience.org/library/papers/4925356PubMed
44,333,538RNA-dependent DNA polymerase activity of RNA tumor viruses. I. Directing influence of DNA in the reaction.J Virol1972https://conductscience.org/library/papers/4333538PubMed
54,354,205Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase.J Biol Chem1973https://conductscience.org/library/papers/4354205PubMed
64,354,722Enzyme induction by viruses.Monogr Virol1969https://conductscience.org/library/papers/4354722PubMed
71,078,615Poly (A) sequences of vaccinia virus messenger RNA: nature, mode of addition and function during translation in vitra and in vivo.Virology1975https://conductscience.org/library/papers/1078615PubMed
8168,404Human cytomegalovirus. III. Virus-induced DNA polymerase.J Virol1975https://conductscience.org/library/papers/168404PubMed
955,415On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase.J Biol Chem1976https://conductscience.org/library/papers/55415PubMed
10130,004[Production of substantial amounts of Friend leukemia virus by a suspension tissue culture line (Eveline suspension cells) (author's transl)].Z Naturforsch C Biosci1975https://conductscience.org/library/papers/130004PubMed

1 to 10 of 21

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Cited by25

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 85 citations.

PMIDTitleJournalYearIn PapersSource
39,337,837Exploring the Effectiveness of Acyclovir against Ranaviral Thymidine Kinases: Molecular Docking and Experimental Validation in a Fish Cell Line.Life (Basel)2024https://conductscience.org/library/papers/39337837PubMed
37,269,015Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series.Infect Agent Cancer2023https://conductscience.org/library/papers/37269015PubMed
33,297,724Targeting viral genome synthesis as broad-spectrum approach against RNA virus infections.Antivir Chem Chemother2020https://conductscience.org/library/papers/33297724PubMed
29,534,607Addressing the selectivity and toxicity of antiviral nucleosides.Antivir Chem Chemother2018https://conductscience.org/library/papers/29534607PubMed
26,836,009
Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.
Biochemistry2016https://conductscience.org/library/papers/26836009PubMed
26,080,445Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo.Proc Natl Acad Sci U S A2015https://conductscience.org/library/papers/26080445PubMed
18,621,425Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approach.Antiviral Res2008https://conductscience.org/library/papers/18621425PubMed
8,265,634Acyclovir diphosphate dimyristoylglycerol: a phospholipid prodrug with activity against acyclovir-resistant herpes simplex virus.Proc Natl Acad Sci U S A1993https://conductscience.org/library/papers/8265634PubMed
6,826,696Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses.J Clin Microbiol1983https://conductscience.org/library/papers/6826696PubMed
6,342,900Clinical pharmacokinetics of acyclovir.Clin Pharmacokinet1983https://conductscience.org/library/papers/6342900PubMed

1 to 10 of 25

See all 25 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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