ConductScience.org, home
Papers
API referenceFor AI assistants

Paper730379

Leukocytic endogenous mediator in Crohn's disease.

Solomons NW and 5 others. Infect Immun, 1978. Cited by 52 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Leukocytic endogenous mediator in Crohn's disease. Papers, record 730379. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/730379

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Leukocytic endogenous mediator in Crohn's disease.
PubMed
Journal
Infect Immun
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
52
iCite
Relative citation ratio, by iCite
2.2
iCite
Revised in PubMed
2021-05-26
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Solomons NWN W
2Elson COC O
3Pekarek RSR S
4Jacob RAR A
5Sandstead HHH H
6Rosenberg IHI H

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Blood ProteinsMajor topic
Crohn DiseaseMajor topic
LeukocytesMajor topic
ZincMajor topic
Adolescent
Adult
Female
Humans
Male
Middle Aged

Source PubMed

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
167,559Effect of acute disease and ACTH on serum zinc proteins.N Engl J Med1977https://conductscience.org/library/papers/67559PubMed
25,423,261Isolation of a zinc alpha-2-macroglobulin from human serum.Biochemistry1970https://conductscience.org/library/papers/5423261PubMed
3615,740Zinc deficiency in Crohn's disease.Digestion1977https://conductscience.org/library/papers/615740PubMed
45,471,227Serum copper and zinc levels in various pathologic conditions.Am J Clin Pathol1970https://conductscience.org/library/papers/5471227PubMed
55,038,025An endogenous mediator of depression of amino acids and trace metals in serum during typhoid fever.J Infect Dis1972https://conductscience.org/library/papers/5038025PubMed
64,691,265Multiple biological activities of a partially purified leukocytic endogenous mediator.Am J Physiol1973https://conductscience.org/library/papers/4691265PubMed
74,399,096Characterization of the endogenous mediator(s) of serum zinc and iron depression during infection and other stresses.Proc Soc Exp Biol Med1971https://conductscience.org/library/papers/4399096PubMed
81,091,555Detection of a leukocytic endogenous mediator-like mediator of serum amino acid and zinc depression during various infectious illnesses.Infect Immun1975https://conductscience.org/library/papers/1091555PubMed
94,611,159Metal-albumin-amino acid interactions: chemical and physiological interrelationships.Adv Exp Med Biol1974https://conductscience.org/library/papers/4611159PubMed
104,624,853The effect of leukocytic endogenous mediator (LEM) on the tissue distribution of zinc and iron.Proc Soc Exp Biol Med1972https://conductscience.org/library/papers/4624853PubMed
1156,952A study of zinc distribution in human serum.Bioinorg Chem1976https://conductscience.org/library/papers/56952PubMed
1257,058Distribution of serum zinc between albumin and alpha2-macroglobulin in patients with decompensated hepatic cirrhosis.Eur J Clin Invest1976https://conductscience.org/library/papers/57058PubMed
134,594,065Zinc nutrition in the United States.Am J Clin Nutr1973https://conductscience.org/library/papers/4594065PubMed
144,645,750The effect of leukocytic endogenous mediator (LEM) on serum copper and ceruloplasmin concentrations in the rat.Proc Soc Exp Biol Med1972https://conductscience.org/library/papers/4645750PubMed
151,091,398Effect of foodstuffs on the absorption of zinc sulfate.Clin Pharmacol Ther1975https://conductscience.org/library/papers/1091398PubMed
161,248,701Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.Gastroenterology1976https://conductscience.org/library/papers/1248701PubMed
17402,281Reduced binding of added zinc in serum of patients with decompensated hepatic cirrhosis.Eur J Clin Invest1977https://conductscience.org/library/papers/402281PubMed

Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 52 citations.

PMIDTitleJournalYearIn PapersSource
41,714,459The role of metal metabolism in inflammatory bowel disease: Pathogenesis, clinical application, and therapeutic targets.Immunol Res2026https://conductscience.org/library/papers/41714459PubMed
24,271,987The zinc, copper, and manganese status of children with malabsorption syndromes and inborn errors of metabolism.Biol Trace Elem Res1982https://conductscience.org/library/papers/24271987PubMed
7,285,724Zinc nutrition in Crohn's disease.Dig Dis Sci1981https://conductscience.org/library/papers/7285724PubMed
6,832,625Relationship between trace elements, sugar consumption, and taste in Crohn's disease.Gut1983https://conductscience.org/library/papers/6832625PubMed
6,813,200Clinical experience of zinc supplementation during intravenous nutrition in Crohn's disease: value of serum and urine zinc measurements.Gut1982https://conductscience.org/library/papers/6813200PubMed
3,829,879Urinary zinc excretion in Crohn's disease.Dig Dis Sci1987https://conductscience.org/library/papers/3829879PubMed
3,350,980Reduced concentrations of selenium in mild Crohn's disease.J Clin Pathol1988https://conductscience.org/library/papers/3350980PubMed
3,264,697
Mechanism of anaemia in rheumatoid arthritis: demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro.
Ann Rheum Dis1988https://conductscience.org/library/papers/3264697PubMed
3,197,581Zinc clearance correlates with clinical severity of Crohn's disease. A kinetic study.Dig Dis Sci1988https://conductscience.org/library/papers/3197581PubMed
2,873,002Zinc absorption in inflammatory bowel disease.Dig Dis Sci1986https://conductscience.org/library/papers/2873002PubMed
2,838,424Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline.Infect Immun1988https://conductscience.org/library/papers/2838424PubMed
2,527,574The biological activities of interleukin-1.Blut1989https://conductscience.org/library/papers/2527574PubMed
1,955,773Pathogenetic and clinical relevance of cytokines in inflammatory bowel disease.Immunol Res1991https://conductscience.org/library/papers/1955773PubMed
1,955,169Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease.Gut1991https://conductscience.org/library/papers/1955169PubMed
1,280,980Zinc uptake by blood cells of rats in zinc deficiency and inflammation.Biol Trace Elem Res1992https://conductscience.org/library/papers/1280980PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/730379

GET https://conductscience.org/api/papers/v1/730379/authors

API referenceFor AI assistants