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Paper · 75242

The role of H-2 linked genes in helper T-cell function. II. Isolation on antigen-pulsed macrophages of two separate populations of F1 helper T cells each specific for antigen and one set of parental H-2 products.

Swierkosz JE and 3 others. J Exp Med, 1978. Cited by 126 papers, by iCite.

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ConductScience Library. The role of H-2 linked genes in helper T-cell function. II. Isolation on antigen-pulsed macrophages of two separate populations of F1 helper T cells each specific for antigen and one set of parental H-2 products. Papers, record 75242. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/75242

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The role of H-2 linked genes in helper T-cell function. II. Isolation on antigen-pulsed macrophages of two separate populations of F1 helper T cells each specific for antigen and one set of parental H-2 products.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
126
iCite
Relative citation ratio, by iCite
2.45
iCite
Revised in PubMed
2021-12-03
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Swierkosz JEJ E
2Rock KK
3Marrack PP
4Kappler JWJ W

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Genes, MHC Class IIMajor topic
H-2 AntigensMajor topic
Lymphocyte CooperationMajor topic
MacrophagesMajor topic
T-LymphocytesMajor topic
Animals
Cell Separation
Epitopes
Female
Genetic Linkage
Hybridization, Genetic
Immunosuppression Therapy
Mice

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,079,849The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.J Exp Med1975https://conductscience.org/library/papers/1079849PubMed
21,084,997Role of major histocompatibility complex gene products in delayed-type hypersensitivity.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1084997PubMed
31,085,339
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.
J Exp Med1976https://conductscience.org/library/papers/1085339PubMed
41,085,419Helper T cells recognise antigen and macrophage surface components simultaneously.Nature1976https://conductscience.org/library/papers/1085419PubMed
51,097,572The modulation of lymphocyte functions by molecules secreted by macrophages. I. Description and partial biochemical analysis.J Exp Med1975https://conductscience.org/library/papers/1097572PubMed
61,097,577In vitro selection and extended culture of antigen-specific T lymphocytes. I. Description of selection culture procedure and initial characterization of selected cells.J Exp Med1975https://conductscience.org/library/papers/1097577PubMed
71,100,764Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.J Exp Med1975https://conductscience.org/library/papers/1100764PubMed
816,073,428Determinant selection is a macrophage dependent immune response gene function.Nature1977https://conductscience.org/library/papers/16073428PubMed
9233,906Independent populations of primed F1 guinea pig T lymphocytes respond to antigen-pulsed parental peritoneal exudate cells.J Exp Med1977https://conductscience.org/library/papers/233906PubMed
10300,778Nature of the antigenic complex recognized by T lymphocytes II. T-cell activation by direct modification of macrophage histocompatibility antigens.J Exp Med1977https://conductscience.org/library/papers/300778PubMed

1 to 10 of 38

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Cited by47

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 126 citations.

PMIDTitleJournalYearIn PapersSource
30,824,527Structure and function of the immune system in the spleen.Sci Immunol2019https://conductscience.org/library/papers/30824527PubMed
27,185,856Bridging channel dendritic cells induce immunity to transfused red blood cells.J Exp Med2016https://conductscience.org/library/papers/27185856PubMed
7,276,826
Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus-dependent antigen, and lack of allogeneic restriction between T and B cells.
J Exp Med1981https://conductscience.org/library/papers/7276826PubMed
7,026,722
Role of the major histocompatibility complex in T cell activation of B cell subpopulations. Major histocompatibility complex-restricted and -unrestricted B cell responses are mediated by distinct B cell subpopulations.
J Exp Med1981https://conductscience.org/library/papers/7026722PubMed
7,021,751
Role of the major histocompatibility complex in T cell activation of B cell subpopulations Lyb-5+ and Lyb-5- B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition.
J Exp Med1981https://conductscience.org/library/papers/7021751PubMed
6,975,940
Functional helper activity of monoclonal T cell populations: antigen-specific and H-2 restricted cloned T cells provide help for in vitro antibody responses to trinitrophenyl-poly(LTyr,Glu)-poly(DLAla)--poly(LLys).
Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6975940PubMed
6,972,435
Cell-interaction molecules on immunocompetent lymphocytes. Development of anti-parent cell-interaction-molecule-receptor reactions in F1 hybrid mice and evidence for a unique F1 hybrid subset of interacting cells.
J Exp Med1981https://conductscience.org/library/papers/6972435PubMed
6,808,075Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules.J Exp Med1982https://conductscience.org/library/papers/6808075PubMed
6,607,969Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation.J Exp Med1984https://conductscience.org/library/papers/6607969PubMed
6,602,200Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation.J Exp Med1983https://conductscience.org/library/papers/6602200PubMed

1 to 10 of 47

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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