Paper · 768523

Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance.

Snustad DP and 3 others. J Virol, 1976. Cited by 24 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance. Papers, record 768523. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/768523

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance.; PubMed
Journal: J Virol; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/768523/; PubMed
DOI: https://doi.org/10.1128/jvi.18.1.268-288.1976; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC515546/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 24; iCite
Relative citation ratio, by iCite: 0.58; iCite
Revised in PubMed: 2020-07-24; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Snustad DP	D P
2	Bursch CJ	C J
3	Parson KA	K A
4	Hefeneider SH	S H

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Bacterial Proteins	Major topic
Coliphages	Major topic
DNA, Bacterial	Major topic
Escherichia coli	Major topic
Mutation	Major topic
Cell Nucleus
Cell-Free System
DNA Viruses
DNA, Viral
Endonucleases
Enzyme Induction
Galactosidases
Viral Proteins
Virus Replication

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References54

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,943,684	Inhibition of host deoxyribonucleic acid synthesis by T4 bacteriophage in the absence of protein synthesis.	J Virol	1971	https://conductscience.org/library/papers/4943684	PubMed
2	4,918,524	Biological activity of bacteriophage ghosts and "take-over" of host functions by bacteriophage.	Bacteriol Rev	1970	https://conductscience.org/library/papers/4918524	PubMed
3	4,916,323	Early intracellular events in the replication of bacteriophage T4 deoxyribonucleic acid. V. Further studies on the T4 protein-deoxyribonucleic acid complex.	J Virol	1970	https://conductscience.org/library/papers/4916323	PubMed
4	16,562,073	Assay for the Killing Properties of T2 Bacteriophage and Their "Ghosts".	J Bacteriol	1965	https://conductscience.org/library/papers/16562073	PubMed
5	14,405,215	Electron microscopical studies of phage multiplication. IV. The establishment of the DNA pool of vegetative phage and the maturation of phage particles.	Virology	1959	https://conductscience.org/library/papers/14405215	PubMed
6	13,802,337	Thermal conversion of nonpriming deoxyribonucleic acid to primer.	J Biol Chem	1959	https://conductscience.org/library/papers/13802337	PubMed
9	13,916,671	A critical test of a current theory of genetic recombination in bacteriophage.	Genetics	1962	https://conductscience.org/library/papers/13916671	PubMed
10	14,480,263	RNA metabolism in Escherichia coli infected with bacteriophage T4. Inhibition of host ribosomal and soluble RNA synthesis by phage and effect of chloromycetin.	J Mol Biol	1962	https://conductscience.org/library/papers/14480263	PubMed
18	4,114,321	Nuclear disruption after infection of Escherichia coli with a bacteriophage T4 mutant unable to induce endonuclease II.	J Virol	1972	https://conductscience.org/library/papers/4114321	PubMed
19	4,371,081	Chemical structure of a modification of the Escherichia coli ribonucleic acid polymerase alpha polypeptides induced by bacteriophage T4 infection.	J Biol Chem	1974	https://conductscience.org/library/papers/4371081	PubMed

1 to 10 of 54

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Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 24 citations.

PMID	Title	Journal	Year	In Papers	Source
29,876,748	The plasmid vectors, pBS2ndd and pBS3ndd, for versatile cloning with low background in Escherichia coli.	World J Microbiol Biotechnol	2018	https://conductscience.org/library/papers/29876748	PubMed
12,626,685	Bacteriophage T4 genome.	Microbiol Mol Biol Rev	2003	https://conductscience.org/library/papers/12626685	PubMed
8,932,296	Short-range and long-range context effects on coliphage T4 endonuclease II-dependent restriction.	J Bacteriol	1996	https://conductscience.org/library/papers/8932296	PubMed
7,086,957	Genetic analysis of bacteriophage T4 transducing bacteriophages.	J Virol	1982	https://conductscience.org/library/papers/7086957	PubMed
6,358,795	Physical and genetical analysis of bacteriophage T4 generalized transduction.	Mol Gen Genet	1983	https://conductscience.org/library/papers/6358795	PubMed
6,355,761	Incorporation of thymine-containing DNA precursors in wild-type and mutant T4-infected plasmolysed cells.	Mol Gen Genet	1983	https://conductscience.org/library/papers/6355761	PubMed
3,897,193	Plasmid-dependent inhibition of growth of bacteriophage T4 ndd mutants.	J Bacteriol	1985	https://conductscience.org/library/papers/3897193	PubMed
3,783,815	The bacteriophage T4 regulatory protein gpunf/alc binds to DNA in the absence of RNA polymerase.	J Virol	1986	https://conductscience.org/library/papers/3783815	PubMed
2,960,831	Wild-type bacteriophage T4 is restricted by the lambda rex genes.	J Virol	1987	https://conductscience.org/library/papers/2960831	PubMed
2,578,570	Bacteriophage T4 unf (=alc) gene function is required for late replication in the presence of plasmid pR386.	J Virol	1985	https://conductscience.org/library/papers/2578570	PubMed

1 to 10 of 14

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
GLB1	2,720	PubTator's text mining	https://conductscience.org/library/genes/2720

Source NCBI Gene

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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