Paper7783225
The class II aminoacyl-tRNA synthetases and their active site: evolutionary conservation of an ATP binding site.
Eriani G and 7 others. J Mol Evol, 1995. Cited by 41 papers, by iCite.
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ConductScience Library. The class II aminoacyl-tRNA synthetases and their active site: evolutionary conservation of an ATP binding site. Papers, record 7783225. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7783225
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The class II aminoacyl-tRNA synthetases and their active site: evolutionary conservation of an ATP binding site.
- PubMed
Topics21
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Adenosine Triphosphate | Major topic |
| Amino Acyl-tRNA Synthetases | Major topic |
| Biological Evolution | Major topic |
| Allosteric Site | |
| Amino Acid Sequence | |
| Aspartate-tRNA Ligase | |
| Bacterial Proteins | |
| Binding Sites | |
| Consensus Sequence | |
| Fungal Proteins | |
| Models, Molecular | |
| Molecular Sequence Data | |
| Protein Binding | |
| Protein Conformation | |
| RNA, Transfer | |
| RNA, Transfer, Asp | |
| Saccharomyces cerevisiae | |
| Sequence Alignment | |
| Sequence Homology, Amino Acid | |
| Species Specificity | |
| Structure-Activity Relationship |
Source PubMed
References38
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 3,056,726 | Tyrosyl-tRNA synthetase from baker's yeast. Order of substrate addition, discrimination of 20 amino acids in aminoacylation of tRNATyr-C-C-A and tRNATyr-C-C-A(3'NH2). | Eur J Biochem | 1988 | https://conductscience.org/library/papers/3056726 | PubMed |
| 2 | 7,019,723 | Methionyl-tRNA synthetase shows the nucleotide binding fold observed in dehydrogenases. | Nature | 1981 | https://conductscience.org/library/papers/7019723 | PubMed |
| 3 | 8,360,919 | Origin of glutaminyl-tRNA synthetase: an example of palimpsest? | J Mol Evol | 1993 | https://conductscience.org/library/papers/8360919 | PubMed |
| 4 | 4,368,490 | Chemical and biological evolution of nucleotide-binding protein. | Nature | 1974 | https://conductscience.org/library/papers/4368490 | PubMed |
| 5 | 3,607,872 | A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof. | Cell | 1987 | https://conductscience.org/library/papers/3607872 | PubMed |
| 6 | 8,313,877 | The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction. | EMBO J | 1994 | https://conductscience.org/library/papers/8313877 | PubMed |
| 7 | 356,880 | Aminoacyl-tRNA synthetases from yeast: generality of chemical proofreading in the prevention of misaminoacylation of tRNA. | Biochemistry | 1978 | https://conductscience.org/library/papers/356880 | PubMed |
| 8 | 3,315,663 | Isoleucyl-tRNA synthetase from baker's yeast and from Escherichia coli MRE 600. Discrimination of 20 amino acids in aminoacylation of tRNA(Ile)-C-C-A(3'NH2). | Eur J Biochem | 1987 | https://conductscience.org/library/papers/3315663 | PubMed |
| 9 | 2,693,216 | Asparaginyl-tRNA synthetase from Escherichia coli has significant sequence homologies with yeast aspartyl-tRNA synthetase. | Gene | 1989 | https://conductscience.org/library/papers/2693216 | PubMed |
| 10 | 1,103,136 | Amino acids are not all initially attached to the same position on transfer RNA molecules. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1103136 | PubMed |
| 11 | 7,265,210 | Amino acid activation in crystalline tyrosyl-tRNA synthetase from Bacillus stearothermophilus. | J Mol Biol | 1981 | https://conductscience.org/library/papers/7265210 | PubMed |
| 12 | 8,248,175 | Role of dimerization in yeast aspartyl-tRNA synthetase and importance of the class II invariant proline. | Proc Natl Acad Sci U S A | 1993 | https://conductscience.org/library/papers/8248175 | PubMed |
| 13 | 2,183,178 | Homology of lysS and lysU, the two Escherichia coli genes encoding distinct lysyl-tRNA synthetase species. | Nucleic Acids Res | 1990 | https://conductscience.org/library/papers/2183178 | PubMed |
| 14 | 3,096,385 | Sequence similarities among the family of aminoacyl-tRNA synthetases. | Biochimie | 1986 | https://conductscience.org/library/papers/3096385 | PubMed |
| 15 | 8,199,244 | Phenylalanyl-tRNA synthetase from Thermus thermophilus has four antiparallel folds of which only two are catalytically functional. | Biochimie | 1993 | https://conductscience.org/library/papers/8199244 | PubMed |
| 16 | 2,691,248 | Arginyl-tRNA synthetase from yeast. Discrimination between 20 amino acids in aminoacylation of tRNA(Arg)-C-C-A and tRNA(Arg)-C-C-A(3'NH2). | Eur J Biochem | 1989 | https://conductscience.org/library/papers/2691248 | PubMed |
| 17 | 8,163,518 | The invariant arginine in motif 2 of Escherichia coli alanyl-tRNA synthetase is important for catalysis but not for substrate binding. | J Biol Chem | 1994 | https://conductscience.org/library/papers/8163518 | PubMed |
| 18 | 8,128,220 | The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser). | Science | 1994 | https://conductscience.org/library/papers/8128220 | PubMed |
| 19 | 382,994 | Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs. | Annu Rev Biochem | 1979 | https://conductscience.org/library/papers/382994 | PubMed |
| 20 | 2,047,877 | Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp). | Science | 1991 | https://conductscience.org/library/papers/2047877 | PubMed |
Cited by13
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 41 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 40,627,786 | Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target. | PLoS Pathog | 2025 | https://conductscience.org/library/papers/40627786 | PubMed |
| 37,151,504 | Aminoacyl tRNA Synthetases: Implications of Structural Biology in Drug Development against Trypanosomatid Parasites. | ACS Omega | 2023 | https://conductscience.org/library/papers/37151504 | PubMed |
| 30,728,021 | Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study. | Malar J | 2019 | https://conductscience.org/library/papers/30728021 | PubMed |
| 30,140,040 | Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach. | Sci Rep | 2018 | https://conductscience.org/library/papers/30140040 | PubMed |
| 25,476,837 | Evolutionary and structural annotation of disease-associated mutations in human aminoacyl-tRNA synthetases. | BMC Genomics | 2014 | https://conductscience.org/library/papers/25476837 | PubMed |
| 25,416,776 | Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog. | J Biol Chem | 2015 | https://conductscience.org/library/papers/25416776 | PubMed |
| 24,493,149 | Guanidine hydrochloride mediated denaturation of E. coli Alanyl-tRNA synthetase: identification of an inactive dimeric intermediate. | Protein J | 2014 | https://conductscience.org/library/papers/24493149 | PubMed |
| 19,443,655 | Plasmodial aspartyl-tRNA synthetases and peculiarities in Plasmodium falciparum. | J Biol Chem | 2009 | https://conductscience.org/library/papers/19443655 | PubMed |
| 12,787,471 | Functional asymmetry in the lysyl-tRNA synthetase explored by molecular dynamics, free energy calculations and experiment. | BMC Struct Biol | 2003 | https://conductscience.org/library/papers/12787471 | PubMed |
| 9,409,149 | Archaea and the prokaryote-to-eukaryote transition. | Microbiol Mol Biol Rev | 1997 | https://conductscience.org/library/papers/9409149 | PubMed |
| 9,144,212 | Four primordial modes of tRNA-synthetase recognition, determined by the (G,C) operational code. | Proc Natl Acad Sci U S A | 1997 | https://conductscience.org/library/papers/9144212 | PubMed |
| 8,710,896 | Translocation events in the evolution of aminoacyl-tRNA synthetases. | Proc Natl Acad Sci U S A | 1996 | https://conductscience.org/library/papers/8710896 | PubMed |
| 8,643,439 | The presence of codon-anticodon pairs in the acceptor stem of tRNAs. | Proc Natl Acad Sci U S A | 1996 | https://conductscience.org/library/papers/8643439 | PubMed |
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- PMC's ID filePublic domain (US government)
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- PubTator 3Public domain
- UniProtCC BY 4.0
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- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
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- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
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