Paper · 7938003

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Pellerin L and 1 other. Proc Natl Acad Sci U S A, 1994. Cited by 2,331 papers, by iCite.

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ConductScience Library. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Papers, record 7938003. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7938003

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1994; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/7938003/; PubMed
DOI: https://doi.org/10.1073/pnas.91.22.10625; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC45074/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 2,331; iCite
Relative citation ratio, by iCite: 60.7; iCite
Revised in PubMed: 2022-03-30; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Pellerin L	L
2	Magistretti PJ	P J

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Astrocytes	Major topic
Cerebral Cortex	Major topic
Deoxyglucose	Major topic
Glutamic Acid	Major topic
Glycolysis	Major topic
Neurons	Major topic
Aerobiosis
Animals
Animals, Newborn
Biological Transport
Brain
Cells, Cultured
Excitatory Amino Acid Antagonists
Lactates
Mice
Models, Neurological
Radionuclide Imaging
Sodium-Potassium-Exchanging ATPase
Tritium

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References41

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,291,916	The role of membrane phosphoglycerate kinase in the control of glycolytic rate by active cation transport in human red blood cells.	J Gen Physiol	1967	https://conductscience.org/library/papers/4291916	PubMed
2	1,314,044	Molecular neurobiology of glutamate receptors.	Annu Rev Physiol	1992	https://conductscience.org/library/papers/1314044	PubMed
3	1,608,978	Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.	Proc Natl Acad Sci U S A	1992	https://conductscience.org/library/papers/1608978	PubMed
4	1,618,937	Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy.	J Cereb Blood Flow Metab	1992	https://conductscience.org/library/papers/1618937	PubMed
5	1,631,079	Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.	Proc Natl Acad Sci U S A	1992	https://conductscience.org/library/papers/1631079	PubMed
6	1,448,171	The glial cell glutamate uptake carrier countertransports pH-changing anions.	Nature	1992	https://conductscience.org/library/papers/1448171	PubMed
7	1,362,805	Astrocyte glutamate uptake during chemical hypoxia in vitro.	Neurosci Lett	1992	https://conductscience.org/library/papers/1362805	PubMed
8	8,455,025	Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat.	J Neurochem	1993	https://conductscience.org/library/papers/8455025	PubMed
9	8,483,920	Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes.	Proc Natl Acad Sci U S A	1993	https://conductscience.org/library/papers/8483920	PubMed
10	8,099,882	Glutamate transporters from brain. A novel neurotransmitter transporter family.	FEBS Lett	1993	https://conductscience.org/library/papers/8099882	PubMed

1 to 10 of 41

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Cited by1,231

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,331 citations.

PMID	Title	Journal	Year	In Papers	Source
42,985,291	Integrating multi-receptor and neuron-glia mechanisms of ketamine's antidepressant action: a convergence framework for understanding efficacy.	Front Mol Neurosci	2026	https://conductscience.org/library/papers/42985291	PubMed
42,978,998	Cognitive demand as a neurometabolic stress test in diabetes-associated cognitive impairment: from static metabolite pools to dynamic energy responses.	Front Endocrinol (Lausanne)	2026	https://conductscience.org/library/papers/42978998	PubMed
42,972,384	Astrocyte lipid metabolism in brain health and neurodegeneration: from regulatory hub to maladaptive stressor.	Mol Neurodegener	2026	https://conductscience.org/library/papers/42972384	PubMed
42,955,568	Mitochondrial Lactate Signaling and Protein Lactylation in Neurological Diseases.	Mol Neurobiol	2026	https://conductscience.org/library/papers/42955568	PubMed
42,941,275	Is It Possible to Bypass the Block in Cerebral Glucose Uptake Following TBI with Exogenous Lactate?	Metabolites	2026	https://conductscience.org/library/papers/42941275	PubMed
42,925,132	Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor-Selective Deficits.	Glia	2026	https://conductscience.org/library/papers/42925132	PubMed
42,908,519	Astrocyte maturation creates a stage-specific niche that instructs hippocampal neurogenesis.	Front Cell Neurosci	2026	https://conductscience.org/library/papers/42908519	PubMed
42,907,604	Lipid-fuelled synaptic plasticity: integrating membrane turnover, β-oxidation, and protein lipidation.	EMBO J	2026	https://conductscience.org/library/papers/42907604	PubMed
42,891,801	A Review of the Molecular Evidence for Near-Infrared Light in Astrocyte-Mediated Neurorehabilitation.	Mol Neurobiol	2026	https://conductscience.org/library/papers/42891801	PubMed
42,890,756	Lactate-Informed Exercise Prescription in Mild Cognitive Impairment and Alzheimer's Disease: A Translational Framework for Preserving Cognition, Mobility, and Independence.	Clin Interv Aging	2026	https://conductscience.org/library/papers/42890756	PubMed

1 to 10 of 1,231

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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