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Paper · 794878

Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Gellert M and 3 others. Proc Natl Acad Sci U S A, 1976. Cited by 696 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Papers, record 794878. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/794878

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1976
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
696
iCite
Relative citation ratio, by iCite
16.9
iCite
Revised in PubMed
2019-12-10
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gellert MM
2O'Dea MHM H
3Itoh TT
4Tomizawa JJ

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Anti-Bacterial AgentsMajor topic
DNA, BacterialMajor topic
Escherichia coliMajor topic
NovobiocinMajor topic
Nucleic Acid ConformationMajor topic
PyrrolesMajor topic
Aminocoumarins
Colicins
Coumarins
DNA Replication
DNA, Circular
DNA, Viral
Mutation
Plasmids

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,055,366Integrative recombination of bacteriophage lambda DNA in vitro.Proc Natl Acad Sci U S A1975https://conductscience.org/library/papers/1055366PubMed
2934,288Covalently closed circular DNA molecules deficient in superhelical density as intermediates in plasmid life cycle.Nature1976https://conductscience.org/library/papers/934288PubMed
314,257,703NOVEL INTRA-CELLULAR FORMS OF LAMBDA DNA.J Mol Biol1964https://conductscience.org/library/papers/14257703PubMed
4792,457An electron microscopic comparison of transcription on linear and superhelical DNA.J Mol Biol1976https://conductscience.org/library/papers/792457PubMed
51,068,464Restriction assay for integrative recombination of bacteriophage lambda DNA in vitro: requirement for closed circular DNA substrate.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1068464PubMed
64,598,305Replication of colicin E1 plasmid DNA in cell extracts. II. Selective synthesis of early replicative intermediates.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4598305PubMed
74,333,613A buoyant method for the determination of the superhelix density of closed circular DNA.J Mol Biol1971https://conductscience.org/library/papers/4333613PubMed
84,295,585Enzymatic joining of DNA strands, II. An enzyme-adenylate intermediate in the dpn-dependent DNA ligase reaction.Proc Natl Acad Sci U S A1967https://conductscience.org/library/papers/4295585PubMed
91,249,842Mechanism of mitochondrial DNA replication in mouse L-cells: topology of circular daughter molecules and dynamics of catenated oligomer formation.J Mol Biol1976https://conductscience.org/library/papers/1249842PubMed
10782,523Coumerimycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. II. In vivo characterization.Biochemistry1976https://conductscience.org/library/papers/782523PubMed

1 to 10 of 25

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Cited by321

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 696 citations.

PMIDTitleJournalYearIn PapersSource
42,836,310Adaptation-coupled CRISPRi identifies antibiotic-sensitizing genes leading to a novel plasmid selection marker.Nucleic Acids Res2026https://conductscience.org/library/papers/42836310PubMed
42,306,948A high-throughput fluorescent DNA cleavage assay for discovering bacterial DNA gyrase poisons.Nucleic Acids Res2026https://conductscience.org/library/papers/42306948PubMed
42,268,685Selective targeting of a histone-like silencer Sfx to the R6K conjugal transfer operon.Nucleic Acids Res2026https://conductscience.org/library/papers/42268685PubMed
42,047,214The Human Gut Microbiome Metabolizes Diverse Bioactive Coumarins via α,β-Unsaturated Lactone Reduction.J Nat Prod2026https://conductscience.org/library/papers/42047214PubMed
42,031,167Ngt-1: A glycosyltransferase that confers resistance to three distinct antibiotic classes.J Biol Chem2026https://conductscience.org/library/papers/42031167PubMed
41,809,004Selective targeting of a histone-like silencer Sfx to the R6K conjugal transfer operon.bioRxiv2026https://conductscience.org/library/papers/41809004PubMed
41,721,470Coumarin-Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents.Chem Biol Drug Des2026https://conductscience.org/library/papers/41721470PubMed
41,645,172Targeted suppression of DNA polymerase θ enhances calcium flux and triggers intrinsic apoptosis in gastric cancer.Cancer Cell Int2026https://conductscience.org/library/papers/41645172PubMed
41,634,047The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling.Nat Commun2026https://conductscience.org/library/papers/41634047PubMed
41,591,340Enzyme-DNA Interactions Affect the Catalytic Inhibition of Mycobacterial Gyrases by Antibacterial Drugs.ACS Infect Dis2026https://conductscience.org/library/papers/41591340PubMed

1 to 10 of 321

See all 321 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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