Paper · 8058792

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

Larue L and 3 others. Proc Natl Acad Sci U S A, 1994. Cited by 759 papers, by iCite.

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ConductScience Library. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Papers, record 8058792. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8058792

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: E-cadherin null mutant embryos fail to form a trophectoderm epithelium.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1994; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8058792/; PubMed
DOI: https://doi.org/10.1073/pnas.91.17.8263; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC44586/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 759; iCite
Relative citation ratio, by iCite: 15.3; iCite
Revised in PubMed: 2022-02-28; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Larue L	L
2	Ohsugi M	M
3	Hirchenhain J	J
4	Kemler R	R

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Blastocyst	Major topic
Cadherins	Major topic
Ectoderm	Major topic
Embryonic and Fetal Development	Major topic
Genes, Lethal	Major topic
Mutation	Major topic
Trophoblasts	Major topic
Animals
Base Sequence
Epithelial Cells
Epithelium
Exons
Genetic Vectors
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Messenger
Recombination, Genetic
Restriction Mapping

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References14

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	8,236,461	From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion.	Trends Genet	1993	https://conductscience.org/library/papers/8236461	PubMed
2	6,159,985	A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos.	Cell	1980	https://conductscience.org/library/papers/6159985	PubMed
3	3,897,439	The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium.	J Embryol Exp Morphol	1985	https://conductscience.org/library/papers/3897439	PubMed
4	2,419,126	Identification of a putative cell adhesion domain of uvomorulin.	EMBO J	1985	https://conductscience.org/library/papers/2419126	PubMed
5	3,090,189	The role of cell adhesion in the synchronization and orientation of polarization in 8-cell mouse blastomeres.	J Embryol Exp Morphol	1986	https://conductscience.org/library/papers/3090189	PubMed
6	3,024,164	Transgenesis by means of blastocyst-derived embryonic stem cell lines.	Proc Natl Acad Sci U S A	1986	https://conductscience.org/library/papers/3024164	PubMed
7	1,638,988	Synthesis and phosphorylation of uvomorulin during mouse early development.	Development	1992	https://conductscience.org/library/papers/1638988	PubMed
8	3,315,781	Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos.	Dev Biol	1987	https://conductscience.org/library/papers/3315781	PubMed
9	3,183,602	Stage-specific response of preimplantation mouse embryos to W-7, a calmodulin antagonist.	J Exp Zool	1988	https://conductscience.org/library/papers/3183602	PubMed
10	3,058,163	From egg to epithelium.	Annu Rev Cell Biol	1988	https://conductscience.org/library/papers/3058163	PubMed

1 to 10 of 14

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Cited by310

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 759 citations.

PMID	Title	Journal	Year	In Papers	Source
42,909,366	Reprogramming of Human Limbal Niche Progenitors.	Int J Med Sci	2026	https://conductscience.org/library/papers/42909366	PubMed
42,856,487	Defining redundancy in the stickers and spacers of the cell-cell junction protein Canoe's intrinsically disordered region.	bioRxiv	2026	https://conductscience.org/library/papers/42856487	PubMed
42,665,223	Loss of ephrin-A5 leads to clinical signs of Peters Anomaly in a mouse model.	Exp Eye Res	2026	https://conductscience.org/library/papers/42665223	PubMed
42,525,541	A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1.	Mol Biol Cell	2026	https://conductscience.org/library/papers/42525541	PubMed
42,239,457	A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1.	bioRxiv	2026	https://conductscience.org/library/papers/42239457	PubMed
42,164,853	Vitrification-warming delays preimplantation development and impairs mitochondrial function and cytoplasmic lattices integrity in mouse embryos.	iScience	2026	https://conductscience.org/library/papers/42164853	PubMed
42,030,532	E-cadherin expression promotes tumor growth via KLRG1-dependent pathways.	J Immunol	2026	https://conductscience.org/library/papers/42030532	PubMed
41,704,615	Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers.	Front Oncol	2026	https://conductscience.org/library/papers/41704615	PubMed
41,704,048	Free apical surface hetero-cellular CDH1 homophilic binding is a major mediator of blastocyst-endometrium interaction in humans.	Hum Reprod	2026	https://conductscience.org/library/papers/41704048	PubMed
41,291,012	The HUSH complex facilitates the exit of pluripotency.	Commun Biol	2025	https://conductscience.org/library/papers/41291012	PubMed

1 to 10 of 310

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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