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Paper · 831755

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.

Peto R and 9 others. Br J Cancer, 1977. Cited by 8,246 papers, by iCite.

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ConductScience Library. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Papers, record 831755. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/831755

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
PubMed
Journal
Br J Cancer
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
8,246
iCite
Relative citation ratio, by iCite
302
iCite
Revised in PubMed
2022-03-17
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Peto RR
2Pike MCM C
3Armitage PP
4Breslow NEN E
5Cox DRD R
6Howard SVS V
7Mantel NN
8McPherson KK
9Peto JJ
10Smith PGP G

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Drug EvaluationMajor topic
Statistics as TopicMajor topic
Humans
Leukemia
Methods
Mortality
Multiple Myeloma
Prognosis
Remission, Spontaneous
Research Design
Time Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials2

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT00188149Optimization of the Primary Therapy for Patients With Hodgkin's Disease and Evaluation of PETBackgroundClinicalTrials.gov
NCT06176638Resettled Refugee Families for HealingBackgroundClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References5

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,594,339Statistical methods for the identification and use of prognostic factors.Int J Cancer1974https://conductscience.org/library/papers/4594339PubMed
24,182,654Active immunotherapy for acute lymphoblastic leukaemia.Lancet1969https://conductscience.org/library/papers/4182654PubMed
35,910,392Evaluation of survival data and two new rank order statistics arising in its consideration.Cancer Chemother Rep1966https://conductscience.org/library/papers/5910392PubMed
41,056,801BCG in the treatment of acute lymphocytic leukemia.Blood1975https://conductscience.org/library/papers/1056801PubMed
54,793,138Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data.Biometrics1973https://conductscience.org/library/papers/4793138PubMed

Cited by1,355

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 8,246 citations.

PMIDTitleJournalYearIn PapersSource
42,362,705Electrical resistance measurement in feline cutaneous squamous cell carcinoma treated with electrochemotherapy: a pilot study.Sci Rep2026https://conductscience.org/library/papers/42362705PubMed
42,026,499Aspartate aminotransferase-to-lymphocyte ratio predicts in-hospital mortality in patients with severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study.BMC Infect Dis2026https://conductscience.org/library/papers/42026499PubMed
41,985,005Chromosome 15q deletions confer inferior outcomes among children with ETV6::RUNX1 B-cell acute lymphoblastic leukemia.Blood Adv2026https://conductscience.org/library/papers/41985005PubMed
41,984,995Adding induction intrathecal cytarabine in newly diagnosed CNS2 B-acute lymphoblastic leukemia does not improve outcomes.Blood Adv2026https://conductscience.org/library/papers/41984995PubMed
41,731,415Retention and predictors of loss-to-follow-up among patients on antiretroviral therapy in the Test-and-Treat Era: evidence from a retrospective cohort study in Maputo, Mozambique.BMC Infect Dis2026https://conductscience.org/library/papers/41731415PubMed
41,729,085Prognostic Value of a Semi-Quantitative Score Based on 123 I-MIBG SPECT/CT in Pediatric Patients With Stage 4 High-Risk Neuroblastoma After Induction Therapy.Clin Nucl Med2026https://conductscience.org/library/papers/41729085PubMed
41,697,469RET germline mutations drive tumorigenesis but not tumor aggressiveness in MEN 2.Endocrine2026https://conductscience.org/library/papers/41697469PubMed
41,495,464Exploration of refined humane endpoints for melioidosis in BALB/c mice.Lab Anim (NY)2026https://conductscience.org/library/papers/41495464PubMed
41,437,255Non-housing assets and all-cause mortality in middle-aged and older Chinese adults: a National cohort study.Popul Health Metr2025https://conductscience.org/library/papers/41437255PubMed
41,143,597Sequential Combination of Unfavorable Histology, Followed by Clinical Stage M, Defines High-Risk Neuroblastoma: A Report from the Children's Oncology Group.Clin Cancer Res2026https://conductscience.org/library/papers/41143597PubMed

1 to 10 of 1,355

See all 1,355 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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