Paper · 8456

Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells.

Hutson NJ and 4 others. J Biol Chem, 1976. Cited by 352 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells. Papers, record 8456. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8456

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells.; PubMed
Journal: J Biol Chem; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8456/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 352; iCite
Relative citation ratio, by iCite: 10.7; iCite
Revised in PubMed: 2021-02-10; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Hutson NJ	N J
2	Brumley FT	F T
3	Assimacopoulos FD	F D
4	Harper SC	S C
5	Exton JH	J H

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adrenergic alpha-Agonists	Major topic
Epinephrine	Major topic
Gluconeogenesis	Major topic
Glycogen Synthase	Major topic
Liver	Major topic
Phenylephrine	Major topic
Phosphorylases	Major topic
Animals
Cyclic AMP
Glucagon
Kinetics
Phenoxybenzamine
Propranolol
Rats

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by52

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 352 citations.

PMID	Title	Journal	Year	In Papers	Source
42,415,409	Catecholamines Activate a Tumour Progression Program in Differentiated Tumour Hepatocytes.	Liver Int	2026	https://conductscience.org/library/papers/42415409	PubMed
39,259,165	Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice.	Am J Physiol Endocrinol Metab	2024	https://conductscience.org/library/papers/39259165	PubMed
37,389,954	Bedding as a variable affecting fasting blood glucose and vascular physiology in mice.	Am J Physiol Heart Circ Physiol	2023	https://conductscience.org/library/papers/37389954	PubMed
36,327,900	The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity.	Neuron	2022	https://conductscience.org/library/papers/36327900	PubMed
35,326,472	The Role of Catecholamines in Pathophysiological Liver Processes.	Cells	2022	https://conductscience.org/library/papers/35326472	PubMed
34,388,249	Pathophysiological Mechanisms That Alter the Autonomic Brain-Liver Communication in Metabolic Diseases.	Endocrinology	2021	https://conductscience.org/library/papers/34388249	PubMed
34,071,350	Targeting Adrenergic Receptors in Metabolic Therapies for Heart Failure.	Int J Mol Sci	2021	https://conductscience.org/library/papers/34071350	PubMed
27,516,169	Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.	Nat Rev Drug Discov	2016	https://conductscience.org/library/papers/27516169	PubMed
26,964,835	Pancreatic regulation of glucose homeostasis.	Exp Mol Med	2016	https://conductscience.org/library/papers/26964835	PubMed
20,936,117	Role of PPARα in Hepatic Carbohydrate Metabolism.	PPAR Res	2010	https://conductscience.org/library/papers/20936117	PubMed

1 to 10 of 52

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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