Paper · 8457

Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytes.

Cherrington AD and 5 others. J Biol Chem, 1976. Cited by 235 papers, by iCite.

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ConductScience Library. Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytes. Papers, record 8457. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8457

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytes.; PubMed
Journal: J Biol Chem; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8457/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 235; iCite
Relative citation ratio, by iCite: 8.4; iCite
Revised in PubMed: 2021-02-19; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Cherrington AD	A D
2	Assimacopoulos FD	F D
3	Harper SC	S C
4	Corbin JD	J D
5	Park CR	C R
6	Exton JH	J H

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adrenergic alpha-Agonists	Major topic
Cyclic AMP	Major topic
Glucose	Major topic
Liver	Major topic
Phenylephrine	Major topic
Protein Kinases	Major topic
Animals
Enzyme Activation
Fluorides
Glucagon
Magnesium
Osmolar Concentration
Phenoxybenzamine
Potassium Chloride
Propranolol
Rats
Xanthines

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by31

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 235 citations.

PMID	Title	Journal	Year	In Papers	Source
18,378,671	In search of the message.	J Biol Chem	2008	https://conductscience.org/library/papers/18378671	PubMed
9,095,472	Protein kinase involvement in land snail aestivation and anoxia: protein kinase A kinetic properties and changes in second messenger compounds during depressed metabolism.	Mol Cell Biochem	1996	https://conductscience.org/library/papers/9095472	PubMed
8,385,538	Leukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma.	Br J Pharmacol	1993	https://conductscience.org/library/papers/8385538	PubMed
7,659,081	cAMP-dependent protein kinase and anoxia survival in turtles: purification and properties of liver PKA.	Mol Cell Biochem	1995	https://conductscience.org/library/papers/7659081	PubMed
7,396,872	Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with alpha-adrenergic agonists and with glucagon.	Biochem J	1980	https://conductscience.org/library/papers/7396872	PubMed
7,326,022	The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from L-lactate in isolated rat hepatocytes.	Biochem J	1981	https://conductscience.org/library/papers/7326022	PubMed
6,931,596	Glycogen-storage disease in rats, a genetically determined deficiency of liver phosphorylase kinase.	Biochem J	1980	https://conductscience.org/library/papers/6931596	PubMed
6,812,571	On the mechanism by which hormones induce the release of Ca2+ from mitochondria in the liver cell.	Biochem J	1982	https://conductscience.org/library/papers/6812571	PubMed
6,288,733	Direct cytochemical localization of catalytic subunits dissociated from cAMP-dependent protein kinase in Reuber H-35 hepatoma cells. II. Temporal and spatial kinetics.	J Cell Biol	1982	https://conductscience.org/library/papers/6288733	PubMed
6,253,838	Heterophylic action of ecdysterone. Effect on the cAMP-protein kinase system in mouse.	Naturwissenschaften	1980	https://conductscience.org/library/papers/6253838	PubMed

1 to 10 of 31

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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