Paper8578

In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA. A possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus.

Izui S and 2 others. J Exp Med, 1976. Cited by 317 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA. A possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus. Papers, record 8578. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8578

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA. A possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus.; PubMed
Journal: J Exp Med; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8578/; PubMed
DOI: https://doi.org/10.1084/jem.144.2.428; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2190380/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 317; iCite
Relative citation ratio, by iCite: 10.2; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Izui S	S
2	Lambert PH	P H
3	Miescher PA	P A

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Collagen	Major topic
DNA	Major topic
Kidney Glomerulus	Major topic
Animals
Antigen-Antibody Complex
Basement Membrane
Binding Sites
Complement C1
DNA, Single-Stranded
Humans
Hydrogen-Ion Concentration
Lupus Erythematosus, Systemic
Mice
Osmolar Concentration
Protein Binding
Solubility
Temperature

Source PubMed

Show 11 more topicsShow fewer topics

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	125,288	Deoxyribonucleic acid strandedness. Partial characterization of the antigenic regions binding antibodies in lupus erythematosus serum.	J Clin Invest	1975	https://conductscience.org/library/papers/125288	PubMed
2	1,094,162	Interstitial immune complex nephritis in patients with systemic lupus erythematosus.	Kidney Int	1975	https://conductscience.org/library/papers/1094162	PubMed
3	1,245,740	Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus.	J Immunol	1976	https://conductscience.org/library/papers/1245740	PubMed
4	4,143,707	An immunofluorescent study of the skin lesions in systemic lupus erythematosus.	Arthritis Rheum	1966	https://conductscience.org/library/papers/4143707	PubMed
5	4,158,434	Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. I. Systemic lupus erythematosus.	J Clin Invest	1965	https://conductscience.org/library/papers/4158434	PubMed
6	4,160,044	A method of trace iodination of proteins for immunologic studies.	Int Arch Allergy Appl Immunol	1966	https://conductscience.org/library/papers/4160044	PubMed
7	4,164,260	Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of gamma-globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis.	J Clin Invest	1967	https://conductscience.org/library/papers/4164260	PubMed
8	4,168,098	Immunological studies concerning the nephritis of systemic lupus erythematosus.	J Exp Med	1967	https://conductscience.org/library/papers/4168098	PubMed
9	4,169,964	Pathogenesis of the glomerulonephritis of NZB/W mice.	J Exp Med	1968	https://conductscience.org/library/papers/4169964	PubMed
10	4,208,920	Modification of NZB-NZW F1 autoimmune disease by development of tolerance to DNA.	J Immunol	1974	https://conductscience.org/library/papers/4208920	PubMed
11	4,328,047	Chemical studies of Clq; a modulator of immunoglobulin biology.	Biochem Biophys Res Commun	1971	https://conductscience.org/library/papers/4328047	PubMed
12	4,363,509	Enzymatic digestion of the first component of human complement (C1q).	J Immunol	1974	https://conductscience.org/library/papers/4363509	PubMed
13	4,550,491	Experimental renal disease induced by DNA-anti-DNA immune complexes.	J Clin Invest	1972	https://conductscience.org/library/papers/4550491	PubMed
14	4,557,183	The relation of deoxyribonuclease inhibitor levels to the occurrence of antinuclear antibodies in NZB-NZW mice.	Clin Exp Immunol	1972	https://conductscience.org/library/papers/4557183	PubMed
15	4,607,609	Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysaccharides.	J Exp Med	1974	https://conductscience.org/library/papers/4607609	PubMed
16	4,629,907	The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases.	J Clin Invest	1973	https://conductscience.org/library/papers/4629907	PubMed
17	4,693,646	DNA:anti-DNA complexes: their detection in systemic lupus erythematosus sera.	J Clin Invest	1973	https://conductscience.org/library/papers/4693646	PubMed
18	4,728,683	Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol.	J Immunol	1973	https://conductscience.org/library/papers/4728683	PubMed
19	4,847,246	Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. Quantitation by binding to radiolabeled C1q.	J Clin Invest	1974	https://conductscience.org/library/papers/4847246	PubMed
20	4,866,347	Immunologic factors and clinical activity in systemic lupus erythematosus.	N Engl J Med	1968	https://conductscience.org/library/papers/4866347	PubMed

Show 14 more referencesShow fewer referencesSee all 30 references

Cited by82

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 317 citations.

PMID	Title	Journal	Year	In Papers	Source
42,015,329	Vascular endothelial growth factor (VEGF) biology and its proposed role in rheumatic diseases pathogenesis.	Adv Rheumatol	2026	https://conductscience.org/library/papers/42015329	PubMed
40,718,684	Toward Bioactive Hydrogels: A Tunable Approach via Nucleic Acid-Collagen Complexation.	Regen Eng Transl Med	2024	https://conductscience.org/library/papers/40718684	PubMed
39,869,382	Multifunctional DNA-Collagen Biomaterials: Developmental Advances and Biomedical Applications.	ACS Biomater Sci Eng	2025	https://conductscience.org/library/papers/39869382	PubMed
32,561,285	Mineralized DNA-collagen complex-based biomaterials for bone tissue engineering.	Int J Biol Macromol	2020	https://conductscience.org/library/papers/32561285	PubMed
30,610,165	Lupus-Associated Immune Complexes Activate Human Neutrophils in an FcγRIIA-Dependent but TLR-Independent Response.	J Immunol	2019	https://conductscience.org/library/papers/30610165	PubMed
26,079,958	Biomarkers for kidney involvement in pediatric lupus.	Biomark Med	2015	https://conductscience.org/library/papers/26079958	PubMed
25,102,991	Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus.	Semin Immunopathol	2014	https://conductscience.org/library/papers/25102991	PubMed
23,752,208	Lupus nephritis: enigmas, conflicting models and an emerging concept.	Mol Med	2013	https://conductscience.org/library/papers/23752208	PubMed
21,542,875	Chromatin as a target antigen in human and murine lupus nephritis.	Arthritis Res Ther	2011	https://conductscience.org/library/papers/21542875	PubMed
18,187,568	Lupus nephritis: the central role of nucleosomes revealed.	Am J Pathol	2008	https://conductscience.org/library/papers/18187568	PubMed
17,504,842	Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis.	Ann Rheum Dis	2007	https://conductscience.org/library/papers/17504842	PubMed
16,792,669	Cross-reaction of anti-DNA autoantibodies with membrane proteins of human glomerular mesangial cells in sera from patients with lupus nephritis.	Clin Exp Immunol	2006	https://conductscience.org/library/papers/16792669	PubMed
16,153,890	SLE: translating lessons from model systems to human disease.	Trends Immunol	2005	https://conductscience.org/library/papers/16153890	PubMed
8,878,426	Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.	J Clin Invest	1996	https://conductscience.org/library/papers/8878426	PubMed
8,601,641	Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity.	J Clin Invest	1996	https://conductscience.org/library/papers/8601641	PubMed
8,572,736	Increased release of von Willebrand factor antigen from endothelial cells by anti-DNA autoantibodies.	Ann Rheum Dis	1996	https://conductscience.org/library/papers/8572736	PubMed
8,470,930	Pathogenesis of lupus dermatoses in autoimmune mice. XIX. Attempts to induce subepidermal immunoglobulin deposition in MRL/Mp- +/+ mice.	Arch Dermatol Res	1993	https://conductscience.org/library/papers/8470930	PubMed
8,443,967	Detection of glomerular-binding immune elements in murine lupus using a tissue-based ELISA.	Clin Exp Immunol	1993	https://conductscience.org/library/papers/8443967	PubMed
8,419,071	Specific increases in urinary excretion of anti-DNA antibodies in lupus mice induced by lysozyme administration: further evidence for DNA-anti-DNA immune complexes in the pathogenesis of nephritis.	Clin Exp Immunol	1993	https://conductscience.org/library/papers/8419071	PubMed
8,419,070	Identification of DNA-binding proteins on human umbilical vein endothelial cell plasma membrane.	Clin Exp Immunol	1993	https://conductscience.org/library/papers/8419070	PubMed

Show 14 more cited byShow fewer cited bySee all 82 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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PMC's ID filePublic domain (US government)
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UniProtCC BY 4.0

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