Paper8634
Evidence that brain prostaglandin synthesis is not essential in fever.
Cranston WI and 4 others. J Physiol, 1976. Cited by 74 papers, by iCite.
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ConductScience Library. Evidence that brain prostaglandin synthesis is not essential in fever. Papers, record 8634. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8634
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics12
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Brain | Major topic |
| Fever | Major topic |
| Prostaglandins E | Major topic |
| Animals | |
| Body Temperature | |
| Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide | |
| Female | |
| Injections, Intraventricular | |
| Male | |
| Prostaglandin Antagonists | |
| Pyrogens | |
| Rabbits |
Source PubMed
References24
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,138,292 | Effects of prostaglandin antagonist SC-19220 on body temperature and on hyperthermic responses to prostaglandin E-1 and leukocytic pyrogen in the cat. | Prostaglandins | 1975 | https://conductscience.org/library/papers/1138292 | PubMed |
| 2 | 1,214,227 | A dissociation between fever and prostaglandin concentration in cerebrospinal fluid. | J Physiol | 1975 | https://conductscience.org/library/papers/1214227 | PubMed |
| 3 | 4,208,101 | Drugs which inhibit prostaglandin biosynthesis. | Pharmacol Rev | 1974 | https://conductscience.org/library/papers/4208101 | PubMed |
| 4 | 4,215,879 | Further studies on the role of prostaglandin in fever. | J Physiol | 1974 | https://conductscience.org/library/papers/4215879 | PubMed |
| 5 | 4,330,929 | Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits. | J Physiol | 1971 | https://conductscience.org/library/papers/4330929 | PubMed |
| 6 | 4,348,703 | Thermoregulatory effects of prostaglandins E 1 , E 2 , F 1 and F 2 in the sheep. | Pflugers Arch | 1973 | https://conductscience.org/library/papers/4348703 | PubMed |
| 7 | 4,357,266 | Substances that inhibit the actions of prostaglandins. | Arch Intern Med | 1974 | https://conductscience.org/library/papers/4357266 | PubMed |
| 8 | 4,555,643 | Effects of prostaglandin E 2 on the body temperature of conscious rats and cats. | Arch Int Pharmacodyn Ther | 1972 | https://conductscience.org/library/papers/4555643 | PubMed |
| 9 | 4,568,386 | Pyrogen fever and prostaglandin-like activity in cerebrospinal fluid. | J Physiol | 1973 | https://conductscience.org/library/papers/4568386 | PubMed |
| 10 | 4,588,122 | Effect of pyrogen and antipyretics on prostaglandin acitvity in cisternal c.s.f. of unanaesthetized cats. | J Physiol | 1973 | https://conductscience.org/library/papers/4588122 | PubMed |
| 11 | 4,596,909 | Identification of prostaglandin E by radioimmunoassay in cerebrospinal fluid during endotoxin fever. | Naturwissenschaften | 1974 | https://conductscience.org/library/papers/4596909 | PubMed |
| 12 | 4,733,481 | Prosaglandin E1 fever induced in rabbits. | J Physiol | 1973 | https://conductscience.org/library/papers/4733481 | PubMed |
| 13 | 4,853,915 | Prostaglandins of the E and F series in rabbit cerebrospinal fluid during fever induced by Newcastle disease virus, E. coli-endotoxin, or endogenous pyrogen. | Med Microbiol Immunol | 1974 | https://conductscience.org/library/papers/4853915 | PubMed |
| 14 | 4,982,414 | Antagonism of prostaglandin E2 by 1-acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f) (1,4) oxazepine-10-carbonyl) hydrazine (SC-19220). | Arch Int Pharmacodyn Ther | 1969 | https://conductscience.org/library/papers/4982414 | PubMed |
| 15 | 5,000,553 | Studies on prostaglandin antagonists. | Br J Pharmacol | 1971 | https://conductscience.org/library/papers/5000553 | PubMed |
| 16 | 5,098,081 | Fever produced by prostaglandin E1. | J Physiol | 1971 | https://conductscience.org/library/papers/5098081 | PubMed |
| 17 | 5,157,600 | Further studies on prostaglandin E 1 fever in cats. | J Physiol | 1971 | https://conductscience.org/library/papers/5157600 | PubMed |
| 18 | 5,284,360 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | Nat New Biol | 1971 | https://conductscience.org/library/papers/5284360 | PubMed |
| 19 | 5,549,471 | Central nervous system sites of action of a purified leucocyte pyrogen. | Am J Physiol | 1971 | https://conductscience.org/library/papers/5549471 | PubMed |
| 20 | 5,572,280 | Influence of the duration of experimental fever on salicylate antipyresis in the rabbit. | Br J Pharmacol | 1971 | https://conductscience.org/library/papers/5572280 | PubMed |
Cited by22
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 74 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 8,733,593 | Nitric oxide synthase-cyclo-oxygenase pathways in organum vasculosum laminae terminalis: possible role in pyrogenic fever in rabbits. | Br J Pharmacol | 1996 | https://conductscience.org/library/papers/8733593 | PubMed |
| 7,847,156 | Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids. | Acta Neurochir (Wien) | 1994 | https://conductscience.org/library/papers/7847156 | PubMed |
| 7,411,449 | Prostaglandin E levels in third ventricular cerebrospinal fluid of rabbits during fever and changes in body temperature. | J Physiol | 1980 | https://conductscience.org/library/papers/7411449 | PubMed |
| 7,288,365 | Role of prostaglandin E in the biphasic fever response to endotoxin. | J Exp Med | 1981 | https://conductscience.org/library/papers/7288365 | PubMed |
| 7,069,625 | Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits. | J Physiol | 1982 | https://conductscience.org/library/papers/7069625 | PubMed |
| 6,964,402 | Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. | Proc Natl Acad Sci U S A | 1982 | https://conductscience.org/library/papers/6964402 | PubMed |
| 6,110,458 | Effects of intracerebroventricular floctafenine and indomethacin on body temperature in febrile rabbits. | Br J Pharmacol | 1980 | https://conductscience.org/library/papers/6110458 | PubMed |
| 3,903,650 | Comparison of the action of prostaglandin with endotoxin on thermoregulatory response thresholds. | Pflugers Arch | 1985 | https://conductscience.org/library/papers/3903650 | PubMed |
| 3,739,373 | Is prostaglandin E the neural mediator of the febrile response? The case against a proven obligatory role. | Yale J Biol Med | 1986 | https://conductscience.org/library/papers/3739373 | PubMed |
| 3,739,372 | Prostaglandin E as the neural mediator of the febrile response. | Yale J Biol Med | 1986 | https://conductscience.org/library/papers/3739372 | PubMed |
| 3,488,620 | Prostaglandin E2 and fever: a continuing debate. | Yale J Biol Med | 1986 | https://conductscience.org/library/papers/3488620 | PubMed |
| 3,342,798 | Physical versus pharmacological counter-measures. Studies on febrile rabbits. | Eur J Appl Physiol Occup Physiol | 1988 | https://conductscience.org/library/papers/3342798 | PubMed |
| 3,137,331 | Is the central arachidonic acid cascade system involved in the development of acute-phase response in rabbits? | J Physiol | 1988 | https://conductscience.org/library/papers/3137331 | PubMed |
| 859,659 | Mediation of hyperthermia by prostaglandin E2: a new hypothesis. | Naunyn Schmiedebergs Arch Pharmacol | 1977 | https://conductscience.org/library/papers/859659 | PubMed |
| 593,986 | Prostaglandins and the central nervous system. | Postgrad Med J | 1977 | https://conductscience.org/library/papers/593986 | PubMed |
| 567,328 | Hyperthermic effects of arachidonic acid, prostaglandin E2 and F2alpha in rats. | Pflugers Arch | 1978 | https://conductscience.org/library/papers/567328 | PubMed |
| 480,214 | Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits. | J Physiol | 1979 | https://conductscience.org/library/papers/480214 | PubMed |
| 430,434 | Effects of central administation of probenecid on fevers produced by leukocytic pyrogen and PGE2 in the rabbit. | J Physiol | 1979 | https://conductscience.org/library/papers/430434 | PubMed |
| 317,572 | The antipyretic effect of UP 517-03 in the rabbit. | Agents Actions | 1979 | https://conductscience.org/library/papers/317572 | PubMed |
| 304,749 | The antipyretic effect of tilorone hydrochloride in the cat. | Br J Pharmacol | 1978 | https://conductscience.org/library/papers/304749 | PubMed |
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- 2026-09-18
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- PubTator 3Public domain
- UniProtCC BY 4.0
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- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
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