Paper8729

Intracellular pH and activation of sea urchin eggs after fertilisation.

Johnson JD and 1 other. Nature, 1976. Cited by 485 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Intracellular pH and activation of sea urchin eggs after fertilisation. Papers, record 8729. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8729

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Intracellular pH and activation of sea urchin eggs after fertilisation.; PubMed
Journal: Nature; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8729/; PubMed
DOI: https://doi.org/10.1038/262661a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 485; iCite
Relative citation ratio, by iCite: 13.3; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Johnson JD	J D
2	Epel D	D

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Fertilization	Major topic
Hydrogen-Ion Concentration	Major topic
Zygote	Major topic
Amiloride
Ammonia
Animals
Biological Transport
Cell Division
Cytoplasm
Female
Protons
Sea Urchins
Sodium

Source PubMed

Show 7 more topicsShow fewer topics

Cited by105

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 485 citations.

PMID	Title	Journal	Year	In Papers	Source
36,768,985	Spawning-Induced pH Increase Activates Sperm Attraction and Fertilization Abilities in Eggs of the Ascidian, Phallusia philippinensis and Ciona intestinalis.	Int J Mol Sci	2023	https://conductscience.org/library/papers/36768985	PubMed
36,371,313	Oocyte quality assessment in marine invertebrates: a novel approach by fluorescence spectroscopy.	Biol Res	2022	https://conductscience.org/library/papers/36371313	PubMed
35,893,264	Role of pH in Regulating Cancer Pyrimidine Synthesis.	J Xenobiot	2022	https://conductscience.org/library/papers/35893264	PubMed
35,563,801	Regulation of the Actin Cytoskeleton-Linked Ca2+ Signaling by Intracellular pH in Fertilized Eggs of Sea Urchin.	Cells	2022	https://conductscience.org/library/papers/35563801	PubMed
35,265,608	Toward Best Practices for Controlling Mammalian Cell Culture Environments.	Front Cell Dev Biol	2022	https://conductscience.org/library/papers/35265608	PubMed
34,410,575	COVID-19: the CaMKII-like system of S protein drives membrane fusion and induces syncytial multinucleated giant cells.	Immunol Res	2021	https://conductscience.org/library/papers/34410575	PubMed
34,389,822	A prevalent neglect of environmental control in mammalian cell culture calls for best practices.	Nat Biomed Eng	2021	https://conductscience.org/library/papers/34389822	PubMed
33,659,434	Fluorescence Measurement and Calibration of Intracellular pH in Starfish Oocytes.	Bio Protoc	2020	https://conductscience.org/library/papers/33659434	PubMed
29,895,196	The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells.	Cell Cycle	2018	https://conductscience.org/library/papers/29895196	PubMed
24,253,519	Stimulation of carrot somatic embryogenesis by proline and serine.	Plant Cell Rep	1984	https://conductscience.org/library/papers/24253519	PubMed
23,969,692	Disrupting proton dynamics and energy metabolism for cancer therapy.	Nat Rev Cancer	2013	https://conductscience.org/library/papers/23969692	PubMed
23,077,257	Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification.	Proc Natl Acad Sci U S A	2012	https://conductscience.org/library/papers/23077257	PubMed
22,479,526	Effects of seawater acidification on cell cycle control mechanisms in Strongylocentrotus purpuratus embryos.	PLoS One	2012	https://conductscience.org/library/papers/22479526	PubMed
20,884,330	Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: function, localization, and relevance to neurologic function.	Neuroscience	2010	https://conductscience.org/library/papers/20884330	PubMed
20,497,125	Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP.	Biochem J	2010	https://conductscience.org/library/papers/20497125	PubMed
19,823,673	HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization.	PLoS One	2009	https://conductscience.org/library/papers/19823673	PubMed
19,658,159	Cell surface changes in the egg at fertilization.	Mol Reprod Dev	2009	https://conductscience.org/library/papers/19658159	PubMed
18,263,556	Calcium signalling in early embryos.	Philos Trans R Soc Lond B Biol Sci	2008	https://conductscience.org/library/papers/18263556	PubMed
16,574,439	ITP.	Semin Cell Dev Biol	2006	https://conductscience.org/library/papers/16574439	PubMed
16,371,595	Calcium at fertilization and in early development.	Physiol Rev	2006	https://conductscience.org/library/papers/16371595	PubMed

Show 14 more cited byShow fewer cited bySee all 105 cited by

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The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
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HGNCCC0: https://www.genenames.org/about/license/
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NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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