Paper · 8970988

RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity.

Schultz SJ and 1 other. J Virol, 1996. Cited by 27 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity. Papers, record 8970988. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8970988

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity.; PubMed
Journal: J Virol; PubMed
Year: 1996; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8970988/; PubMed
DOI: https://doi.org/10.1128/jvi.70.12.8630-8638.1996; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC190956/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 27; iCite
Relative citation ratio, by iCite: 0.62; iCite
Revised in PubMed: 2020-07-24; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Schultz SJ	S J
2	Champoux JJ	J J

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA-Directed DNA Polymerase	Major topic
Moloney murine leukemia virus	Major topic
RNA-Directed DNA Polymerase	Major topic
Retroviridae Proteins	Major topic
Ribonuclease H	Major topic
Glutathione Transferase
RNA
RNA, Transfer

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
R37 CA51605	NCI NIH HHS	United States	R37CA051605	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	2,477,553	Plus-strand priming by Moloney murine leukemia virus. The sequence features important for cleavage by RNase H.	J Mol Biol	1989	https://conductscience.org/library/papers/2477553	PubMed
2	2,466,838	Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis, and template switching.	J Biol Chem	1989	https://conductscience.org/library/papers/2466838	PubMed
3	1,688,626	Specificities involved in the initiation of retroviral plus-strand DNA.	J Virol	1990	https://conductscience.org/library/papers/1688626	PubMed
4	1,691,093	HIV-1 RT-associated ribonuclease H displays both endonuclease and 3'----5' exonuclease activity.	EMBO J	1990	https://conductscience.org/library/papers/1691093	PubMed
5	1,691,564	Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase.	Virology	1990	https://conductscience.org/library/papers/1691564	PubMed
6	1,693,920	Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptase.	J Biol Chem	1990	https://conductscience.org/library/papers/1693920	PubMed
7	2,169,648	Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein.	Science	1990	https://conductscience.org/library/papers/2169648	PubMed
8	2,173,791	Plus-strand origin for human immunodeficiency virus type 1: implications for integration.	J Virol	1990	https://conductscience.org/library/papers/2173791	PubMed
9	1,713,059	Human immunodeficiency virus reverse transcriptase ribonuclease H: specificity of tRNA(Lys3)-primer excision.	Biochemistry	1991	https://conductscience.org/library/papers/1713059	PubMed
10	1,718,968	A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active.	J Biol Chem	1991	https://conductscience.org/library/papers/1718968	PubMed

1 to 10 of 47

See all 47 references

Cited by16

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 27 citations.

PMID	Title	Journal	Year	In Papers	Source
31,269,675	Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase.	Viruses	2019	https://conductscience.org/library/papers/31269675	PubMed
24,880,687	Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.	Nucleic Acids Res	2014	https://conductscience.org/library/papers/24880687	PubMed
23,382,176	Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.	Nucleic Acids Res	2013	https://conductscience.org/library/papers/23382176	PubMed
22,962,864	The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding.	Retrovirology	2012	https://conductscience.org/library/papers/22962864	PubMed
22,366,278	Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus.	J Struct Biol	2012	https://conductscience.org/library/papers/22366278	PubMed
22,325,739	Insights into the structure and activity of prototype foamy virus RNase H.	Retrovirology	2012	https://conductscience.org/library/papers/22325739	PubMed
20,358,252	Retroviral reverse transcriptases.	Cell Mol Life Sci	2010	https://conductscience.org/library/papers/20358252	PubMed
20,122,939	Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.	J Mol Biol	2010	https://conductscience.org/library/papers/20122939	PubMed
19,228,195	Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription.	FEBS J	2009	https://conductscience.org/library/papers/19228195	PubMed
18,261,820	RNase H activity: structure, specificity, and function in reverse transcription.	Virus Res	2008	https://conductscience.org/library/papers/18261820	PubMed

1 to 10 of 16

See all 16 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/8970988

GET https://conductscience.org/api/papers/v1/8970988/references?page=2

API reference For AI assistants