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Paper · 8985336

Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2.

Chow YH and 4 others. J Virol, 1997. Cited by 203 papers, by iCite.

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ConductScience Library. Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. Papers, record 8985336. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8985336

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2.
PubMed
Journal
J Virol
PubMed
Year
1997
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
203
iCite
Relative citation ratio, by iCite
4.84
iCite
Revised in PubMed
2020-07-24
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chow YHY H
2Huang WLW L
3Chi WKW K
4Chu YDY D
5Tao MHM H

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA, ViralMajor topic
Hepatitis BMajor topic
Hepatitis B Surface AntigensMajor topic
Hepatitis B VaccinesMajor topic
Hepatitis B virusMajor topic
Interleukin-2Major topic
Protein PrecursorsMajor topic
Vaccines, DNAMajor topic
Animals
Cell Line
Female
Gene Expression
Genetic Engineering
Hepatitis B Antibodies
Humans
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Plasmids
Recombinant Fusion Proteins
T-Lymphocytes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References56

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,360,497Induction of antibodies to a kappa V region by gene immunization.J Immunol1993https://conductscience.org/library/papers/8360497PubMed
27,884,908DNA vaccination against persistent viral infection.J Virol1995https://conductscience.org/library/papers/7884908PubMed
38,662,521Immunostimulatory DNA sequences necessary for effective intradermal gene immunization.Science1996https://conductscience.org/library/papers/8662521PubMed
48,598,468Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.J Immunol1996https://conductscience.org/library/papers/8598468PubMed
57,912,089Acquisition of lymphokine-producing phenotype by CD4+ T cells.Annu Rev Immunol1994https://conductscience.org/library/papers/7912089PubMed
67,884,923DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection.J Virol1995https://conductscience.org/library/papers/7884923PubMed
77,895,169Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines.Immunity1995https://conductscience.org/library/papers/7895169PubMed
87,747,423Protection against EHV-1 challenge infection in the murine model after vaccination with various formulations of recombinant glycoprotein gp14 (gB).Virology1995https://conductscience.org/library/papers/7747423PubMed
97,777,503DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans.Proc Natl Acad Sci U S A1995https://conductscience.org/library/papers/7777503PubMed
107,778,289Immune responses to nucleic acid vaccines to rabies virus.Virology1995https://conductscience.org/library/papers/7778289PubMed

1 to 10 of 56

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Cited by34

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 203 citations.

PMIDTitleJournalYearIn PapersSource
39,742,318Construction and immunological evaluation of recombinant adenovirus vaccines of new novel NADC34-PRRSV strains in pigs.Front Vet Sci2024https://conductscience.org/library/papers/39742318PubMed
26,042,527The catalytic A1 domains of cholera toxin and heat-labile enterotoxin are potent DNA adjuvants that evoke mixed Th1/Th17 cellular immune responses.Hum Vaccin Immunother2015https://conductscience.org/library/papers/26042527PubMed
24,643,207Cimetidine synergizes with Praziquantel to enhance the immune response of HBV DNA vaccine via activating cytotoxic CD8(+) T cell.Hum Vaccin Immunother2014https://conductscience.org/library/papers/24643207PubMed
24,603,502
Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron II gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs.
PLoS One2014https://conductscience.org/library/papers/24603502PubMed
24,053,449Cross-protective immunity against influenza A/H1N1 virus challenge in mice immunized with recombinant vaccine expressing HA gene of influenza A/H5N1 virus.Virol J2013https://conductscience.org/library/papers/24053449PubMed
24,031,690Immune response to dna vaccine expressing transferrin binding protein a gene of Pasteurella multocida.Braz J Microbiol2011https://conductscience.org/library/papers/24031690PubMed
21,508,173Adjuvant activity of the catalytic A1 domain of cholera toxin for retroviral antigens delivered by GeneGun.Clin Vaccine Immunol2011https://conductscience.org/library/papers/21508173PubMed
21,350,664Coexpression of PPE 34.9 Antigen of Mycobacterium avium subsp. Paratuberculosis with Murine Interferon Gamma in HeLa Cell Line and Study of Their Immunogenicity in Murine Model.Biotechnol Res Int2011https://conductscience.org/library/papers/21350664PubMed
19,199,070Coexpression of 16.8 kDa antigen of Mycobacterium avium paratuberculosis and murine gamma interferon in a bicistronic vector and studies on its potential as DNA vaccine.Vet Res Commun2009https://conductscience.org/library/papers/19199070PubMed
18,329,109Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2.J Virol Methods2008https://conductscience.org/library/papers/18329109PubMed

1 to 10 of 34

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
IL23,558PubTator's text mininghttps://conductscience.org/library/genes/3558

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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