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Paper92563

Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.

Read GW and 1 other. J Pharmacol Exp Ther, 1979. Cited by 96 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines. Papers, record 92563. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/92563

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.
PubMed
Journal
J Pharmacol Exp Ther
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
96
iCite
Relative citation ratio, by iCite
3.8
iCite
Revised in PubMed
2018-11-30
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Read GWG W
2Kiefer EFE F

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Benzalkonium CompoundsMajor topic
Histamine ReleaseMajor topic
PolyaminesMajor topic
p-Methoxy-N-methylphenethylamineMajor topic
Animals
Female
Male
Mast Cells
Polyethylene Glycols
Rats
Type C Phospholipases

Source PubMed

Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 96 citations.

PMIDTitleJournalYearIn PapersSource
39,815,634Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase.J Immunotoxicol2024https://conductscience.org/library/papers/39815634PubMed
36,211,198Quaternary ammonium compounds in hypersensitivity reactions.Front Toxicol2022https://conductscience.org/library/papers/36211198PubMed
28,377,880
Paradoxical bronchospasm from benzalkonium chloride (BAC) preservative in albuterol nebulizer solution in a patient with acute severe asthma. A case report and literature review of airway effects of BAC.
Respir Med Case Rep2017https://conductscience.org/library/papers/28377880PubMed
24,812,509Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery.Int J Nanomedicine2014https://conductscience.org/library/papers/24812509PubMed
18,309,682Benzalkonium chloride induced bronchoconstriction in patients with stable bronchial asthma.Korean J Intern Med2007https://conductscience.org/library/papers/18309682PubMed
15,082,905Anaphylaxis caused by benzalkonium in a nebulizer solution.J Korean Med Sci2004https://conductscience.org/library/papers/15082905PubMed
8,713,487Adverse drug events related to dosage forms and delivery systems.Drug Saf1996https://conductscience.org/library/papers/8713487PubMed
8,027,189G-protein ligands inhibit in vitro reactions of vacuole inheritance.J Cell Biol1994https://conductscience.org/library/papers/8027189PubMed
7,643,958Mast cells in neuroimmune function: neurotoxicological and neuropharmacological perspectives.Neurochem Res1995https://conductscience.org/library/papers/7643958PubMed
7,326,027Immunoglobulin E decapeptide-induced 5-hydroxytryptamine release from rat peritoneal mast cells. Comparison with corticotropin-(1-24)-peptide, polyarginine, polylysine and antigen.Biochem J1981https://conductscience.org/library/papers/7326027PubMed
6,209,203On disturbance of homeostasis in organ-cultured tissue.In Vitro1984https://conductscience.org/library/papers/6209203PubMed
6,203,369Mechanism of histamine release from rat isolated peritoneal mast cells by dextran: the role of immunoglobulin E.Agents Actions1984https://conductscience.org/library/papers/6203369PubMed
6,177,220Species and tissue differences of histamine storage and release.Agents Actions1982https://conductscience.org/library/papers/6177220PubMed
3,041,246Pharmaceutical excipients. Adverse effects associated with 'inactive' ingredients in drug products (Part II).Med Toxicol Adverse Drug Exp1988https://conductscience.org/library/papers/3041246PubMed
2,972,308The influence of ipratropium bromide and sodium cromoglycate on benzalkonium chloride-induced bronchoconstriction in asthma.Br J Clin Pharmacol1988https://conductscience.org/library/papers/2972308PubMed
2,954,609Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuliser solution.Br Med J (Clin Res Ed)1987https://conductscience.org/library/papers/2954609PubMed
2,477,717Stimulation by McN-A-343 and blockade by telenzepine of acid secretion in the mouse isolated stomach at histamine-liberating cells.Naunyn Schmiedebergs Arch Pharmacol1989https://conductscience.org/library/papers/2477717PubMed
2,469,022Characteristics of beta-endorphin-induced histamine release from rat serosal mast cells. Comparison with neurotensin, dynorphin and compound 48/80.Naunyn Schmiedebergs Arch Pharmacol1988https://conductscience.org/library/papers/2469022PubMed
2,451,929The contribution of histamine release to bronchoconstriction provoked by inhaled benzalkonium chloride in asthma.Br J Clin Pharmacol1988https://conductscience.org/library/papers/2451929PubMed
2,440,265Action of the SP2-11 and SP3-11 fragments of substance P on rat peritoneal mast cells.Agents Actions1987https://conductscience.org/library/papers/2440265PubMed

See all 27 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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