Paper944697
Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.
Alt FW and 2 others. J Biol Chem, 1976. Cited by 155 papers, by iCite.
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ConductScience Library. Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. Papers, record 944697. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/944697
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.
- PubMed
Topics10
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Methotrexate | Major topic |
| Tetrahydrofolate Dehydrogenase | Major topic |
| Animals | |
| Cell Line | |
| Drug Resistance | |
| Humans | |
| Infant, Newborn | |
| Leucine | |
| Neoplasm Proteins | |
| Sarcoma 180 |
Source PubMed
Cited by42
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 155 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 22,419,077 | Gene overexpression: uses, mechanisms, and interpretation. | Genetics | 2012 | https://conductscience.org/library/papers/22419077 | PubMed |
| 19,732,436 | Networking of differentially expressed genes in human cancer cells resistant to methotrexate. | Genome Med | 2009 | https://conductscience.org/library/papers/19732436 | PubMed |
| 16,667,128 | Coregulation of dihydrofolate reductase and thymidylate synthase in overproducer cell lines of wild carrot. | Plant Physiol | 1989 | https://conductscience.org/library/papers/16667128 | PubMed |
| 8,483,945 | Dexamethasone negatively regulates the activity of a chimeric dihydrofolate reductase/glucocorticoid receptor protein. | Proc Natl Acad Sci U S A | 1993 | https://conductscience.org/library/papers/8483945 | PubMed |
| 7,346,713 | Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines. | Mol Cell Biol | 1981 | https://conductscience.org/library/papers/7346713 | PubMed |
| 7,346,712 | Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line. | Mol Cell Biol | 1981 | https://conductscience.org/library/papers/7346712 | PubMed |
| 7,110,138 | Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines. | Mol Cell Biol | 1982 | https://conductscience.org/library/papers/7110138 | PubMed |
| 7,061,595 | Amplified dihydrofolate reductase genes are located in chromosome regions containing DNA that replicates during the first half of S-phase. | J Cell Biol | 1982 | https://conductscience.org/library/papers/7061595 | PubMed |
| 6,965,250 | Microcell-mediated cotransfer of genes specifying methotrexate resistance, emetine sensitivity, and chromate sensitivity with Chinese hamster chromosome 2. | Mol Cell Biol | 1981 | https://conductscience.org/library/papers/6965250 | PubMed |
| 6,946,445 | S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells. | Proc Natl Acad Sci U S A | 1981 | https://conductscience.org/library/papers/6946445 | PubMed |
| 6,933,469 | Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity. | Proc Natl Acad Sci U S A | 1980 | https://conductscience.org/library/papers/6933469 | PubMed |
| 6,736,126 | Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus. | J Cell Biol | 1984 | https://conductscience.org/library/papers/6736126 | PubMed |
| 6,733,842 | The effect of vinca alkaloids in enhancing the sensitivity of a methotrexate-resistant (L1210/R7A) line, studied by flow cytometric and chromosome number analysis. | Cancer Chemother Pharmacol | 1984 | https://conductscience.org/library/papers/6733842 | PubMed |
| 6,411,680 | Identification of the type I trimethoprim-resistant dihydrofolate reductase specified by the Escherichia coli R-plasmid R483: comparison with procaryotic and eucaryotic dihydrofolate reductases. | J Bacteriol | 1983 | https://conductscience.org/library/papers/6411680 | PubMed |
| 6,328,427 | Expression of the mouse dihydrofolate reductase cDNA in B. subtilis: a system to select mutant cDNAs coding for methotrexate resistant enzymes. | Nucleic Acids Res | 1984 | https://conductscience.org/library/papers/6328427 | PubMed |
| 6,287,233 | Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells. | Mol Cell Biol | 1982 | https://conductscience.org/library/papers/6287233 | PubMed |
| 6,262,725 | Molecular cloning of Chinese hamster dihydrofolate reductase-specific cDNA and the identification of multiple dihydrofolate reductase mRNAs in antifolate-resistant Chinese hamster lung fibroblasts. | Nucleic Acids Res | 1981 | https://conductscience.org/library/papers/6262725 | PubMed |
| 6,217,415 | Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts. | Mol Cell Biol | 1982 | https://conductscience.org/library/papers/6217415 | PubMed |
| 6,215,412 | Selection of tunicamycin-resistant Chinese hamster ovary cells with increased N-acetylglucosaminyltransferase activity. | J Cell Biol | 1982 | https://conductscience.org/library/papers/6215412 | PubMed |
| 6,201,865 | Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture. | Proc Natl Acad Sci U S A | 1984 | https://conductscience.org/library/papers/6201865 | PubMed |
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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- Drugs
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Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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