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Paper · 9502765

Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.

Schultheis PJ and 9 others. J Clin Invest, 1998. Cited by 197 papers, by iCite.

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ConductScience Library. Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. Papers, record 9502765. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9502765

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.
PubMed
Journal
J Clin Invest
PubMed
Year
1998
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
197
iCite
Relative citation ratio, by iCite
4.8
iCite
Revised in PubMed
2018-12-01
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Schultheis PJP J
2Clarke LLL L
3Meneton PP
4Harline MM
5Boivin GPG P
6Stemmermann GG
7Duffy JJJ J
8Doetschman TT
9Miller MLM L
10Shull GEG E

Source PubMed

Topics34

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AcidsMajor topic
Parietal Cells, GastricMajor topic
Sodium-Hydrogen ExchangersMajor topic
Adenosine Triphosphatases
Amino Acid Sequence
Animals
Blotting, Northern
Cell Survival
Cells, Cultured
Chromosome Mapping
Cloning, Molecular
DNA
Female
Gastric Mucosa
Gastrins
Intestinal Mucosa
Isomerism
Kidney
Male
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Knockout
Molecular Sequence Data
Mutagenesis
Pepsinogens
Polymerase Chain Reaction
Potassium
Pregnancy
Protons
RNA, Messenger
Recombination, Genetic
Sequence Analysis, DNA
Stem Cells

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R29 DK048816NIDDK NIH HHSUnited StatesR29DK048816PubMed and NIHNIH RePORTER
DK-39626NIDDK NIH HHSUnited StatesR01DK039626PubMed and NIHNIH RePORTER
DK-50594NIDDK NIH HHSUnited StatesR01DK050594PubMed and NIHNIH RePORTER
HL-41496NHLBI NIH HHSUnited StatesP01HL041496PubMed and NIHNIH RePORTER
R37DK050594NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,141,271Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa.Am J Physiol1994https://conductscience.org/library/papers/8141271PubMed
28,244,989Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells.J Biol Chem1993https://conductscience.org/library/papers/8244989PubMed
38,020,660Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa.Gastroenterology1994https://conductscience.org/library/papers/8020660PubMed
48,089,122Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.J Biol Chem1994https://conductscience.org/library/papers/8089122PubMed
57,961,960A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.J Biol Chem1994https://conductscience.org/library/papers/7961960PubMed
67,707,229Different regulation by pHi and osmolarity of the rabbit ileum brush-border and parietal cell basolateral anion exchanger.J Physiol1994https://conductscience.org/library/papers/7707229PubMed
77,631,751Role of basolateral Na(+)-K(+)-Cl- cotransport in HCl secretion by amphibian gastric mucosa.Am J Physiol1995https://conductscience.org/library/papers/7631751PubMed
88,631,828Three N-terminal variants of the AE2 Cl-/HCO3- exchanger are encoded by mRNAs transcribed from alternative promoters.J Biol Chem1996https://conductscience.org/library/papers/8631828PubMed
98,625,770Metabolic base production and mucosal vulnerability during acid inhibition in a mammalian stomach in vitro.Dig Dis Sci1996https://conductscience.org/library/papers/8625770PubMed
108,631,979Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice.J Biol Chem1996https://conductscience.org/library/papers/8631979PubMed

1 to 10 of 37

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Cited by87

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 197 citations.

PMIDTitleJournalYearIn PapersSource
42,635,895NHE1 in Gastrointestinal Inflammation and Cancer: A Double-Edged Regulator.Dig Dis Sci2026https://conductscience.org/library/papers/42635895PubMed
40,314,091The function of chloride channels in digestive system disease (Review).Int J Mol Med2025https://conductscience.org/library/papers/40314091PubMed
38,733,994Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells.Cell Stem Cell2024https://conductscience.org/library/papers/38733994PubMed
38,397,074Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.Int J Mol Sci2024https://conductscience.org/library/papers/38397074PubMed
37,293,144Role of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases.Am J Cancer Res2023https://conductscience.org/library/papers/37293144PubMed
36,189,974Downregulation of NHE-3 (SLC9A3) expression by MicroRNAs in intestinal epithelial cells.Am J Physiol Cell Physiol2022https://conductscience.org/library/papers/36189974PubMed
36,142,772The Physiological Function and Potential Role of the Ubiquitous Na+/H+ Exchanger Isoform 8 (NHE8): An Overview Data.Int J Mol Sci2022https://conductscience.org/library/papers/36142772PubMed
35,665,228The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity.Front Physiol2022https://conductscience.org/library/papers/35665228PubMed
35,514,347The Na+/H+ Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension.Front Physiol2022https://conductscience.org/library/papers/35514347PubMed
35,426,084SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.Cell Oncol (Dordr)2022https://conductscience.org/library/papers/35426084PubMed

1 to 10 of 87

See all 87 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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